Effect of nordihydroguaiaretic acid on intracellular Ca2+ concentrations in C6 glioma cells

Su, Warren; Tseng, Li Ling; Lin, Muh Chiou; Chang, Hsin Ju; Lee, Kam Chung; Chou, Kang Ju; Lo, Yuk Keung; Cheng, Jin; Chang, Hong; Wang, Jue Long; Liu, Chun Peng; Chen, Wei‐Chung; Jan, Chung Ren

doi:10.1016/s0197-0186(01)00089-4

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…NDGA has also been shown to increase intracellular calcium levels in C6 glioma cells in a concentrationdependent manner (Su et al, 2002). Pretreatment with the calcium channel blockers verapamil and nifedipine had no effect on NDGA-induced increases.…”

Section: Cancer Chemotherapymentioning

confidence: 99%

Nordihydroguaiaretic Acid: A Review of Its Numerous and Varied Biological Activities

Lambert

Dorr

Timmermann

2004

Pharmaceutical Biology

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Nordihydroguaiaretic acid (NDGA) is a lignan found in large amounts in the ethnobotanically important plant, Larrea tridentata (Moc. & Sess.) Cov. (Zygophyllaceae). Research on this compound and its natural and synthetic derivatives has shown them to be potentially useful in the treatment of cancer, diabetes, viral and bacterial infections, and as regulators of fertility. The usefulness of these compounds is hindered by the lack of understanding of the mechanisms of action for each activity. While a great deal of observational and correlative data have been reported, there have been few comprehensive mechanistic or structure-function studies conducted on NDGA. Additionally, toxicological and pharmacokinetic data on NDGA is rather sparse and the metabolic breakdown products of this compound have not been reported. The present review is meant to summarize many of the biological activities reported for NDGA and its derivatives and to draw attention to areas which need to be further explored in the hopes of stimulating research on this potentially useful natural product.

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Section: Cancer Chemotherapymentioning

confidence: 99%

Nordihydroguaiaretic Acid: A Review of Its Numerous and Varied Biological Activities

Lambert

Dorr

Timmermann

2004

Pharmaceutical Biology

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“…NDGA is originally thought to act as a lipoxygenases inhibitor (Trang et al, 2003), but recently many other effects of this agent have been shown, such as anti-oxidation , induction of apoptosis (Hausott et al, 2003), viral inhibition (Huang et al, 2003), membrane alterations (Fujiwara et al, 2003), activation of Ca 2+ -dependent K + channels in smooth muscle cells (Yamamura et al, 1999), breakdown of pre-formed Alzheimer's beta-amyloid fibrils in vitro (Ono et al, 2002), elevation of cellular Ca 2+ level Wang et al, 2001;Su et al, 2002), etc. These effects appear to be dissociated from inhibition of lipoxygenases.…”

Section: Introductionmentioning

confidence: 99%

Nordihydroguaiaretic acid-induced Ca2+ handling and cytotoxicity in human prostate cancer cells

et al. 2004

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Modulation of Calcium Signaling in Glioblastoma Multiforme: A Therapeutic Promise for Natural Products

Afshari

Mollazadeh

Soukhtanloo

et al. 2020

MRMC

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: Glioblastoma multiforme (GBM) continues as one of the most lethal cerebral cancers despite standard therapeutic modalities, such as maximum surgical resection and chemoradiation. The minimal effectiveness of existing therapies necessitates the development of additional drug candidates that could improve the prognosis of GBM patients. Accumulating evidence suggests that calcium (Ca2+) is involved in the processes of cell proliferation, metastasis, angiogenesis, migration, and invasiveness. Therefore, Ca2+ could serve as a crucial regulator of tumorigenesis and a potential treatment target in GBM. In this context, specific natural products are known to modulate Ca2+ signaling pathways implicated in tumor growth, apoptosis, angiogenesis, and development of GBM. Here, we focus on the function of Ca2+ as a therapeutic target in GBM and review certain natural products that affect the signaling pathways of Ca2+.

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Effect of nordihydroguaiaretic acid on intracellular Ca2+ concentrations in C6 glioma cells

Cited by 4 publications

References 22 publications

Nordihydroguaiaretic Acid: A Review of Its Numerous and Varied Biological Activities

Nordihydroguaiaretic Acid: A Review of Its Numerous and Varied Biological Activities

Nordihydroguaiaretic acid-induced Ca2+ handling and cytotoxicity in human prostate cancer cells

Modulation of Calcium Signaling in Glioblastoma Multiforme: A Therapeutic Promise for Natural Products

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