Effect of noradrenaline, dopamine and 5-hydroxytryptamine on body temperature in the rat after intracisternal administration

Bruinvels, J.

doi:10.1016/0028-3908(70)90077-8

Cited by 53 publications

(14 citation statements)

References 13 publications

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“…The presence of a regular relationship between dose and thermoregulatory response does not prove that the injected agents acted on specific receptors. However, the absence of a highly irregular or bell-shaped dose-effect relationship is significant, for these latter functional relationships have been considered indicative of non-specific activity (Beckman, 1970;Bruinvels, 1970). ( The spinal cord as the site of action for NA, 5-HT and CCh injected intrathecally A drug injected into the lumbar subarachnoid space might be carried in the c.s.f.…”

Section: Discussionmentioning

confidence: 99%

The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space

LoPachin

Rudy

1982

The Journal of Physiology

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SUMMARY1. We have examined the effects on thermoregulation in the rat of noradrenaline bitartrate (NA), 5-hydroxytryptamine hydrochloride (5-HT) and carbamylcholine chloride (CCh) injected into the lumbar spinal subarachnoid space via a chronic indwelling catheter.2. Intrathecal injections of the monoamines and CCh reproducibly affected thermoregulation, whereas injections of control solutions had no effect.3. Intrathecal injections of NA (001-030 smol) produced a dose-dependent hypothermia associated with a decrease in tail skin vasomotor tone. Shivering activity was not depressed during the hypothermia and sometimes increased.Intrathecal administration of the a-adrenergic agonist clonidine (00175-0070 Itmol) elicited changes in Tc and Tsk similar to those induced by intrathecal NA.4. Intrathecal 5-HT (0030-090 ,mol) elicited a dose-dependent hyperthermia accompanied by increased tail skin vasomotor tone and increased shivering.5. CCh injected intrathecally (0001-0406 #smol) evoked a dose-dependent hyperthermia. During the period when core temperature was rising, tail skin vasomotor tone increased and shivering-like activity was present. Once the maximum core temperature had been reached, tail skin vasodilatation occurred. Vasodilatation persisted until core temperature had returned to normal.6. Intravenous injections of 5-HT (030 and 090 /smol) or CCh (0006 and 003 tmol) caused no thermoregulatory effect. The effects of these agents injected intrathecally were therefore not due to an action in the periphery.7. Intravenous infusions of NA (006 and 0 10 smol) produced hypothermia and transient tail skin vasodilatation. We suggest that an action at peripheral sites may have contributed to the effects produced by intrathecal injection of this monamine.8. These findings suggest that spinal noradrenergic, serotonergic and cholinergic synapses may be importantly involved in the control of body temperature in the rat. The possible functional roles of these synapses and the putative spinal sites of action of the injected substances are discussed. R. M. LOPACHIN AND T. A RUDY

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Section: Discussionmentioning

confidence: 99%

The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space

LoPachin

Rudy

1982

The Journal of Physiology

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“…Hypothermia in the rat was produced following the injection of 5-HT either intraventricularly (Feldberg & Lotti, 1967b) or intracisternally (Bruinvels, 1970). Ketamine-induced hyothermia appears to be mediated centrally and not peripherally since it was not antagonized by either methysergide or ergotamine.…”

Section: -Ht In Ketamine-induced Hypothermia Discussionmentioning

confidence: 99%

Role of 5‐hydroxytryptamine in ketamine‐induced hypothermia in the rat

Fahim¹,

Ismail²,

Osman³

1973

British J Pharmacology

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Summary1. Intraperitoneal injection of graded doses of ketamine produced a dosedependent fall in body temperature of rats. Similarly, intracerebral injection of much smaller doses produced hypothermia. 2. Pretreatment of the rats with p-chlorophenylalanine (PCPA) greatly attenuated the hypothermic response to ketamine whereas the intraperitoneal injection of 5-hydroxytryptophan in PCPA-treated rats restored the hypothermic effect of ketamine. 3. Depletion of the brain monoamines by reserpine completely prevented the ketamine-induced hypothermia. Treatment with sodium diethyldithiocarbamate (DEDTC), however, did not modify the hypothermic effect of ketamine. 4. Pretreatment of the rats with pargyline potentiated the ketamine-induced hypothermia. 5. Depletion of brain monoamines by reserpine in combination with inhibition of noradrenaline biosynthesis (DEDTC) resulted in a long lasting fall in temperature which was not modified by ketamine. 6. When the ambient temperature was raised from 260 C to 320 C, ketamineinduced hypothermia was much reduced and superimposed on a hyperthermia which occurred in all animals. 7. It is concluded that ketamine produces hypothermia in rats possibly through the release of 5-hydroxytryptamine in the hypothalamus and that this effect is similar in some respects to that produced by morphine in non-tolerant rats.

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“…In contrast, dopamine has been less well investigated and before 1971 only small or inconsistent changes in body temperature had been recorded after intraventricular or intracisternal injection of the amine (Brittain & Handley, 1967;Myers & Yaksh, 1968;Bruinvels, 1970). The advent of specific agonists and antagonists at the dopamine receptor significantly affected the work in this field when it was shown that intracerebroventricular injection ofthe specific agonist, apomorphine, produced hypothermia in the rat which was blocked by the specific antagonist, pimozide (Kruk, 1972).…”

Section: Introductionmentioning

confidence: 99%

Do Central Dopamine Receptors Have a Physiological Role in Thermoregulation?

Cox

Lee

1977

British J Pharmacology

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I Core and tail skin temperature was measured in rats which had guide cannulae implanted into their brains to allow drug injections directly into the preoptic anterior hypothalamus.2 Apomorphine and dopamine (10 gg in 1 gl) injected into the area of the preoptic anterior hypothalamus caused a fall in core temperature which was preceded by a rise in tail skin temperature. 3 The decrease in core temperature following central injection of either apomorphine or dopamine was significantly reduced by pretreating rats for 2 h with pimozide (0.5 mg/kg i.p.).4 Bilateral intrahypothalamic injection of pimozide (0.5,g in I gl) significantly reduced the hypothermic effect of systemic apomorphine (1.25 mg/kg i.p.). 5 Control rats placed 65 cm below a 250 W infrared lamp responded with vasodilatation of tail skin blood vessels as indicated by an increase in tail skin temperature. Pimozide pretreatment (0.5 mg/kg i.p.) significantly reduced this response. 6 These results suggest that the preoptic anterior hypothalamus contains dopamine receptors which mediate hypothermia in rodents and raise the possibility that endogenous dopamine has a physiological role in thermoregulation.

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Effect of noradrenaline, dopamine and 5-hydroxytryptamine on body temperature in the rat after intracisternal administration

Cited by 53 publications

References 13 publications

The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space

The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space

Role of 5‐hydroxytryptamine in ketamine‐induced hypothermia in the rat

Do Central Dopamine Receptors Have a Physiological Role in Thermoregulation?

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