Effect of Nonviral Factors on Hepatitis C Recurrence After Liver Transplantation

Cameron, Andrew M.; Ghobrial, Rafik M.; Hiatt, Jonathan R.; Carmody, Ian C.; Gordon, Sherilyn A.; Farmer, Douglas G.; Yersiz, Hasan; Zimmerman, Michael A.; Durazo, Francisco; Han, Steve; Saab, Sammy; Gornbein, Jeffrey; Busuttil, Ronald W.

doi:10.1097/01.sla.0000237648.90600.e9

Cited by 36 publications

(41 citation statements)

References 44 publications

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“…It was found that there was no significant correlation between donor age and recurrence in the present study, similarly, in the studies by Yosry et al in 2009 [2] and Doris et al in 2010 [11] there were no correlation between donor age and HCV recurrence, In contrast, in the studies by (Berenguer, 2003 [14], Charlton and Menon, 2005 [5], Cameron et al [12], and Francisco et al [10] donor age <31 years was significant predictor of HCV recurrence, perhaps because older grafts are less able to mount an effective immune response against viral recurrence [12].…”

Section: Discussioncontrasting

confidence: 56%

“…Similarly, in the study by Yosry et al in 2009 [2], and Doris et al [11], there was no correlation between recipient age and HCV recurrence. In contrast, in a study by Charlton [5], older recepients, were significantly correlated with more severe recurrence of HCV, perhaps because older patients are less able to mount an effective immune response against viral recurrence [12].…”

Section: Discussionmentioning

confidence: 53%

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Recurrent Hepatitis C Virus (Genotype 4) Infection after Living Donor Liver Transplantation: Risk Factors and Outcome

Salem¹

2014

J Liver

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 53%

Recurrent Hepatitis C Virus (Genotype 4) Infection after Living Donor Liver Transplantation: Risk Factors and Outcome

Salem¹

2014

J Liver

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“…It is unclear whether some of the deleterious effects of older donors are related to inability of the graft to mount an effective antiviral response or if there is some other explanation. Donor age at which this risk increases has been reported at various cutoffs: greater than 60 years [78], greater than 50 years [79], and as low as 40 years [76,[80][81][82][83]. These data beg the question of how organs from older donors should be allocated while balancing HCV status, Model for End-Stage Liver Disease (MELD), and wait times.…”

Section: Increasing Donor Agementioning

confidence: 92%

Liver Transplantation for Hepatitis C: Disease Management

Thompson

Lake

2011

Curr Hepatitis Rep

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Hepatitis C-positive liver transplantation (LT) patients present significant problems in post-transplant management. These patients are known to have more rapid fibrosis progression, and outcomes are worsening in the population, compared to other indications for LT. Decisions regarding selection of immunosuppressants and treatment of rejection are different in these patients, because both may alter the course of progression. HCV recurs universally, and treatment of recurrence is fraught with difficulties in tolerability and low response rates. One option for treating these patients is retransplantation, but this option, too, is controversial. This review discusses each of these issues in detail.

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“…Furthermore, our multivariate analysis revealed that their use is associated with an increased incidence of recurrent hepatitis C (HCV). 14 …”

Section: Donor Agementioning

confidence: 97%

Optimal utilization of extended hepatic grafts

Burroughs

Busuttil

2009

Surg Today

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Orthotopic liver transplantation has emerged as the standard treatment for end-stage liver disease. In the United States, the number of listed patients has tripled in the last two decades. Organ availability during the same period has plateaued at approximately 6000 grafts annually, resulting in a fivefold increase in wait-list mortality. The problem is not specific to the United States; European and Asian registries report similar shortages. Donor pool expansion strategies such as the use of living donors, cadaveric split livers, and "extended criteria donors"; (ECD) are being pursued. Used judiciously, ECD grafts provide an opportunity for addressing the shortage. Although there is no universally accepted definition of ECD, the term generally refers to donor factors predisposing recipients to poor initial graft function and/or increased long-term risk. These factors include advanced donor age, hypernatremia, prolonged warm ischemic time, pressor requirement, and donation after cardiac death. The transplant community is scrutinizing all factors to evaluate the degree of risk they impart on the recipient and the extent to which grafts can be "matched"; to maintain acceptable outcomes. We review the importance of selected factors and the impact of a "matching"; strategy to minimize recipient risk while optimizing graft use.

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Effect of Nonviral Factors on Hepatitis C Recurrence After Liver Transplantation

Cited by 36 publications

References 44 publications

Recurrent Hepatitis C Virus (Genotype 4) Infection after Living Donor Liver Transplantation: Risk Factors and Outcome

Recurrent Hepatitis C Virus (Genotype 4) Infection after Living Donor Liver Transplantation: Risk Factors and Outcome

Liver Transplantation for Hepatitis C: Disease Management

Optimal utilization of extended hepatic grafts

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