Effect of Nonsurgical Periodontal Treatment on C-Reactive Protein Levels in Maintenance Hemodialysis Patients

Yazdi, Farin Kiany; Karimi, Noozhan; Rasouli, Manoochehr; Roozbeh, Jamshid

doi:10.3109/0886022x.2013.777890

Cited by 19 publications

(21 citation statements)

References 46 publications

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“…In addition, the same study found no significant difference in serum CRP levels ( p = 0.23) between HD patients with no/mild periodontitis ( n = 100) and moderate/severe periodontitis ( n = 68). This non-significant relationship between serum CRP levels and severity of periodontal disease was supported by other investigators [10,12]. Moreover, salivary CRP levels in HD patients were reported to be significantly higher compared to both controls and patients with CKD not receiving HD [34].…”

Section: Hemodialysissupporting

confidence: 64%

“…For example, one report showed that serum CRP levels were significantly decreased ( p = 0.001) after periodontal treatment in 41 patients receiving HD [30]. Similar results have also been reported in 77 HD patients treated with non-surgical methods [12]. In contrast, other investigators have reported that serum CRP levels in HD patients with treated chronic periodontitis ( n = 43) were similar ( p = 0.634) to untreated patients ( n = 30) [37].…”

Section: Hemodialysissupporting

confidence: 57%

“…Surprisingly, a recent report suggested that 106 of 107 HD patients (99.1%) exhibit some form of periodontitis [9], and another study also showed that only one of 103 HD patients evaluated had a healthy periodontium [10]. Even if such reports are excluded, many studies have reported that over half of HD patients exhibit periodontitis [11,12,13,14]. Furthermore, most periodontal parameters in HD patients were reported to be significantly higher than those in age-matched control subjects and healthy individuals [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

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Periodontal Disease in Patients Receiving Dialysis

Miyata

Obata

Mochizuki

et al. 2019

IJMS

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Chronic kidney disease (CKD) is characterized by kidney damage with proteinuria, hematuria, and progressive loss of kidney function. The final stage of CKD is known as end-stage renal disease, which usually indicates that approximately 90% of normal renal function is lost, and necessitates renal replacement therapy for survival. The most widespread renal replacement therapy is dialysis, which includes peritoneal dialysis (PD) and hemodialysis (HD). However, despite the development of novel medical instruments and agents, both dialysis procedures have complications and disadvantages, such as cardiovascular disease due to excessive blood fluid and infections caused by impaired immunity. Periodontal disease is chronic inflammation induced by various pathogens and its frequency and severity in patients undergoing dialysis are higher compared to those in healthy individuals. Therefore, several investigators have paid special attention to the impact of periodontal disease on inflammation-, nutrient-, and bone metabolism-related markers; the immune system; and complications in patients undergoing dialysis. Furthermore, the influence of diabetes on the prevalence and severity of manifestations of periodontal disease, and the properties of saliva in HD patients with periodontitis have been reported. Conversely, there are few reviews discussing periodontal disease in patients with dialysis. In this review, we discuss the available studies and review the pathological roles and clinical significance of periodontal disease in patients receiving PD or HD. In addition, this review underlines the importance of oral health and adequate periodontal treatment to maintain quality of life and prolong survival in these patients.

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Section: Hemodialysissupporting

confidence: 64%

Section: Hemodialysissupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

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Periodontal Disease in Patients Receiving Dialysis

Miyata

Obata

Mochizuki

et al. 2019

IJMS

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“…Based on the biological evidence that host defense cells release immunoinflammatory mediators such as IL-6, TNFα, MMPs, and PGE2, and stimulate the production of acute phase proteins such as PCR and hepcidin, in response to periodontal disease, the results of our study are similar to the findings of previous studies. 23,24,25,26 There was a significant reduction in IL-6 and CRP in both groups (with and without periodontal disease), demonstrating that immunoinflammatory mediators and acute phase proteins decrease after inflammation and infection. The hepatic peptide hormone hepcidin regulates the absorption of iron from the diet; plasma iron concentrations and the distribution of iron in the tissues and its increase are linked to the inflammatory and infectious response, leading to a reduction in iron availability.…”

Section: Discussionmentioning

confidence: 91%

The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels

et al. 2019

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Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, highsensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters.

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“…[1112] Concluding remarks of the other studies that the periodontal treatment downturns the elevated CRP levels. [13]…”

Section: Discussionmentioning

confidence: 99%

Evaluating the effectiveness of clarithromycin as an adjunct to scaling and root planing: A randomized clinical trial

Suryaprasanna

Karunakar

et al. 2018

J Indian Soc Periodontol

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Background:Administration of systemic antibiotics may implement persuasive treatment effect for chronic periodontitis by intending tissue-invasive bacteria in addition to accustomed nonsurgical periodontal therapy (NSPT).Aims:The aim of this study was to assess the ancillary effects of oral clarithromycin (CLM) along with NSPT for chronic periodontitis.Materials and Methods:Thirty periodontitis patients were randomly divided into two equal groups in this double-blind, randomized, parallel group, and active-controlled trial: test group – scaling and root planning (SRP) plus CLM (500 mg thrice daily for 7 days, orally) was given, and control group – only SRP was done. Clinical analysis, such as gingival index (GI), probing depth (PD), and clinical attachment loss (CAL), were taken at baseline, 3 months, and 6-month intervals for both groups. Subgingival plaque samples were cultured for periodontopathic organisms. Immunological parameter C-reactive protein (CRP) levels were estimated.Results:SPSS version 14 was used for statistical analysis. The intragroup comparison showed a significant reduction in the mean scores of all the parameters from baseline to 6 months. The intergroup comparison showed a statistically significant reduction of PD from baseline to 3 months (P < 0.001). GI, CAL, and CRP levels were also reduced but not statistically significant. The mean colony-forming units (CFU) of Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) showed a statistically significant reduction from baseline to 3 months only in the test group (P = 0.042) and (P = 0.046), respectively. There was no statistically significant reduction of Aa and Pg at 6 months.Conclusions:CLM conceivably accepted as an addendum to NSPT for a shorter period.

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Effect of Nonsurgical Periodontal Treatment on C-Reactive Protein Levels in Maintenance Hemodialysis Patients

Cited by 19 publications

References 46 publications

Periodontal Disease in Patients Receiving Dialysis

Periodontal Disease in Patients Receiving Dialysis

The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels

Evaluating the effectiveness of clarithromycin as an adjunct to scaling and root planing: A randomized clinical trial

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