Effect of nondipper hypertension on coronary artery disease progression in patients with chronic coronary syndrome

Abstract

Background/aim: It has been suggested that there is a significant progress in coronary artery disease (CAD) by many pathophysiological mechanisms. Non-dipper hypertension (NDH) has been shown to have higher target organ damage and have a higher rate of cardiovascular mortality and morbidity. In this study, we investigated the effect of non-dipper hypertension on the progression of coronary atherosclerosis. Materials and methods:A total of 186 patients who underwent coronary angiography twice between six months and three years were included in the study. Coronary angiography was repeated on the admission day due to angina or positive exercise test and the patients were divided into groups.Results: Progression of coronary artery disease was detected in 58 of 186 patients. 71 of the total patients were found to be non-dipper hypertensive. Non-dipper hypertension, hypertension, diabetes mellitus, low-density lipoprotein, and total cholesterol were found to be effective in the progression of CAD. Among these parameters, it was seen that non-dipper hypertension and hyperlipidemia were the most important independent risk factors. Conclusion:Coronary artery disease is a progressive disease, and this progression depends on many reasons. In our study, we showed that non-dipper hypertension is a new parameter that is effective in CAD progression.

Characteristics of Circadian Blood Pressure Profile in Patients With Acute Coronary Syndrome and Their Association With Thyroid Function

“…The average daily variability of SBP/ DBP in Group I patients was 15.43±0.64 / 13.27±0.68 mm Hg, the mean daytime variability of SBP/DBP was 16 A number of studies have confirmed the relationship between the average daily BP index and cardiovascular events, the development of CHD, and death from its complications [24]. Of particular prognostic significance also is SBP variability -the predictor of the development of acute coronary circulatory disorders and coronary events [23].…”

“…гçíèöþ ïîêàç-íèê³â ââàaeàëè äîñòîâ³ðíîþ ïðè ð³âí³ çíà÷è-ìîñò³ > 95% (ð <0,05). Íèçêîþ äîñë³äaeåíü ï³äòâåðäaeåíî âçàºìîçâ'ÿçîê äîáîâîãî ³íäåêñó ÀÒ ³ç ñåðöåâîñóäèííèìè ïîä³ÿìè, ðîçâèòêîì ²ÕÑ òà ñìåðò³ â³ä ¿¿ óñêëàäíåíü [24]. Âàaeëèâå ïðîãíîñòè÷íå çíà÷åííÿ òàêîae ìຠâàð³àáåëüí³ñòü ÑÀÒ, ùî º ïðåäèêòîðîì ðîçâèòêó ãîñòðèõ ïîðóøåíü êîðîíàðíîãî êðîâîîá³ãó òà êîðîíàðíèõ ïîä³é [23].…”

Relationships between Easily Available Biomarkers and Non-Dipper Blood Pressure Pattern in Patients with Stable Coronary Artery Disease

“…Both ESC and AHA HTN guidelines promote a more extensive use of ABPM in hypertensive patients in order to assess their circadian BP pattern. A non-dipping BP pattern is associated with elevated risk of atherosclerotic events and HTN-mediated target organ damage, accelerated CAD progression and an increased likelihood of obstructive sleep apnea [ 47 , 48 , 49 ]. Previous studies have documented increased inflammatory markers in both hypertensive and normotensive patients with a non-dipping BP profile [ 17 ].…”