Effect of non-enzymatic glycosylation in the epigenetics of cancer

Rehman, Shahnawaz; Aatif, Mohammad; Rafi, Zeeshan; Khan, Mohd Yasir; Shahab, Uzma; Ahmad, Saheem; Farhan, Mohd

doi:10.1016/j.semcancer.2020.11.019

Cited by 27 publications

(27 citation statements)

References 266 publications

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“…6 A). In multiple chronic conditions, AGE-RAGE signaling is associated with persistent inflammatory and oxidative stresses, hormonal and immune dysregulation [ 34 , 35 ], as well as changes to the microbiome [10] , epigenome [36] , and metabolome [37] . In invasive and non-invasive prostate cancer cells, RAGE is preferentially bound by AGE over other potential ligands such as S100 calcium binding protein B [38] .…”

Section: Discussionmentioning

confidence: 99%

Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts

Krisanits

Woods

Nogueira

et al. 2022

Translational Oncology

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Highlights Nutrition associated glycoxidation promotes aggressive prostate tumor growth. AGEs, the final product of glycoxidation were a key pro-tumorigenic effector. Dietary-AGE mediated effects were dependent upon stromal RAGE expression. AGE-RAGE signaling caused a regulatory program of activated stroma & CAF activation. Dietary-AGE effects were reproduced using in vivo, ex vivo and in vitro models.

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Section: Discussionmentioning

confidence: 99%

Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts

Krisanits

Woods

Nogueira

et al. 2022

Translational Oncology

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“…MiRNA-based therapies have been shown to hold great promise via either modulating the oncogene or the tumor suppression gene with miRNAs [ 10 , 25 , 26 ]. Based on the ceRNA hypothesis [ 27 , 28 ], miRNA targets of circ_0008717 in NSCLC cells were investigated.…”

Section: Discussionmentioning

confidence: 99%

Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer

et al. 2022

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Circular RNA (circRNA) circ_0008717 has been revealed to promote cell carcinogenesis in non-small cell lung cancer (NSCLC). Exosomal circRNA packaged into exosomes has been defined as a potential diagnostic and therapeutic biomarker of cancers. However, little attention is focused on the role of circRNAs within exosomes in NSCLC. Exosomes were isolated by ultracentrifugation method and qualified by nanoparticle tracking analysis and Western blot. Levels of circ_0008717, microRNA (miR)-1287-5p, and P21-activated kinase 2 (PAK2) were detected using qRT-PCR and western blot. The interaction between miR-1287-5p and circ_0008717 or PAK2 was investigated. The phenotypes of NSCLC cells with circ_0008717 downregulation were tested. Circ_0008717 was highly expressed in NSCLC. Functionally, circ_0008717 deficiency suppressed cell malignant phenotypes in NSCLC in vitro and in nude mice. Circ_0008717 sponged miR-1287-5p to elevate PAK2, a downstream target of miR-1287-5p. Silencing of miR-1287-5p blocked the antitumor effects of circ_0008717 knockdown in NSCLC cells. Besides, miR-1287-5p repressed cell oncogenic behaviors in NSCLC by targeting PAK2. Besides that, we confirmed that circ_0008717 was incorporated into exosomes in NSCLC cells. Circ_0008717 knockdown inhibited NSCLC tumorigenesis via miR-1287-5p/PAK2 axis, and the extracellular circulating circ_0008717 was transferred through incorporation in exosomes.

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“…It acts as a coactivator of ERα and androgen receptor (AR), and enhances their transcriptional activity in a ligand-dependent manner, thus establishing a positive feedback regulatory loop between LRP16 and ERα / AR [27][28][29] , and is also their target gene. The results showed that the chemical modi cation sites of LRP16 (such as phosphorylation, glycosylation [30] , etc.) involve a variety of biological functions, and its sequence is very similar to the end of human histone H2A1C (a member of the H2AX family).…”

Section: Discussionmentioning

confidence: 99%

LRP16 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma by Regulating Hippo Signaling Pathway

Liu

Xiong

Wang

et al. 2021

Preprint

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The present study aimed to investigate the expression of LRP16 in the development of ESCC and the relationship between Hippo signaling pathway and LRP16. Immunohistochemistry was used to detect the expression of LRP16 in ESCC tissues. After transfection, the expression of LRP16 was detected by reverse transcription quantitative PCR (RT-qPCR) and western blot techniques. Cell counting kit (CCK-8), clone formation experiment, flow cytometry and wound healing were used to determine the proliferation, apoptosis, cell cycle and migration of ESCC cells. The changes of factors related to Hippo signaling pathway were determined via RT-qPCR and western blot experiments. The results showed that the LRP16 expression in ESCC tissues was higher than that in normal tissues. High expression of LRP16 was related to the depth of invasion, TNM stage and lymph node metastasis of ESCC. Furthermore, the knockdown of LRP16 inhibited proliferation, migration and promoted cell apoptosis and made cells arrested in G2/M phase. It also resulted in decreased expression of Yes-associated protein (YAP), and increased expression of mammalian STE20-like protein kinase (MST1/2), suggesting that LRP16 promoted the development of ESCC through Hippo signaling pathway. The results of this study suggest that LRP16 may be a carcinogenic gene of ESCC and promotes the progression of ESCC through the regulation of Hippo signaling pathway. Our study provides a new idea for the diagnosis and treatment of ESCC in the future.

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Effect of non-enzymatic glycosylation in the epigenetics of cancer

Cited by 27 publications

References 266 publications

Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts

Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts

Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer

LRP16 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma by Regulating Hippo Signaling Pathway

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