Effect of NMDA antagonists on rapid and chronic tolerance to ethanol: Importance of intoxicated practice

Khanna, J. M.; Morato, Gina Struffaldi; Chau, A.; Shah, G.; Kalant, H.

doi:10.1016/0091-3057(94)90343-3

Cited by 37 publications

(14 citation statements)

References 26 publications

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“…Similarly, RTOL and CTOL to ethanol hypothermia were significantly correlated across 20 inbred strain means (data not shown, from Crabbe et al, 1982). Numerous studies show similarity of pharmacological responses of measures of RTOL and CTOL Morato, 2000, 2001;Kalant, 1996;Khanna et al, 1991Khanna et al, , 1994. However, in HRT and LRT mice, there was no effect of either MK-801 or D-cycloserine on RTOL (N.R.…”

Section: Discussionmentioning

confidence: 50%

Effects of Genetic and Procedural Variation on Measurement of Alcohol Sensitivity in Mouse Inbred Strains

et al. 2006

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Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT), indexed as the reduction from pre-injection baseline of their body temperature. Two weeks later, mice were tested for their loss of righting reflex (LRR) after a higher dose of ethanol. The LRR was tested using the "classical" method of watching for recovery in animals placed on their backs in a V-shaped trough and recording duration of LRR. In a separate test, naive animals of the same strains were tested for HT repeatedly to assess the development of rapid (RTOL) and chronic tolerance (CTOL). We have recently developed a new method for testing LRR that leads to a substantial increase in the sensitivity of the test. Strains also have been found to differ in the new LRR test, as well as in the development of acute functional tolerance (AFT) to this response. In addition, our laboratory has periodically published strain difference data on the older versions of the HT and LRR responses. The earlier tests used some of the exact substrains tested currently, while for some strains, different substrains (usually, Nih versus Jax) were tested. We examined correlations of strain means to see whether patterns of strain differences were stable across time and across different test variants assessing the same behavioral construct. HT strain sensitivity scores were generally highly correlated across a 10-23 years period and test variants. The CTOL to HT was well-correlated across studies, and was also genetically similar to RTOL. The AFT, however, was related to neither RTOL nor CTOL, although this may be because different phenotypic end points were compared. The LRR data, which included a variant of the classical test, were not as stable. Measures of LRR onset were reasonably well correlated, as were those taken at recovery (e.g., duration). However, the two types of measures of LRR sensitivity to ethanol appear to be tapping traits that differ genetically. Also, the pattern of genetic correlation between HT and LRR initially reported in 1983 was not seen in current and contemporaneous studies. In certain instances, substrain seems to matter little, while in others, substrains differed a great deal. These data are generally encouraging about the stability of genetic differences.

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Section: Discussionmentioning

confidence: 50%

Effects of Genetic and Procedural Variation on Measurement of Alcohol Sensitivity in Mouse Inbred Strains

et al. 2006

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“…on day 2, suggesting that this phenomenon is timedependent, and that pharmacokinetic factors are not entirely responsible for this event. In fact, rapid tolerance seems to be more functional rather than dispositional, since blood ethanol concentrations of experimental and control groups on the second day of the experiment are similar (Khanna et al 1994). In addition, previous studies in our laboratory (Barbosa and Morato 2001;Zaleski et al 2001) have demonstrated that the administration of drugs that were able to prevent the development of rapid tolerance to ethanol in mice did not alter the blood ethanol levels on day 1.…”

Section: Discussionmentioning

confidence: 91%

Blockade of adenosine and dopamine receptors inhibits the development of rapid tolerance to ethanol in mice

et al. 2005

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“…In animal behavioral studies, NMDA antagonists such as MK-801 and ketamine have been shown to inhibit both acute and chronic tolerance to ethanol [12,13]. These studies suggested a close similarity between acute and chronic tolerances and the involvement of NMDA receptors in the development of ethanol tolerance.…”

Section: Discussionmentioning

confidence: 97%

Acute tolerance to ethanol inhibition of NMDA-induced responses in rat rostral ventrolateral medulla neurons

2004

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The present study was performed to examine the effects of acute ethanol exposure on N-methyl-D-aspartate (NMDA)-induced responses and the development of acute tolerance in rat rostral ventrolateral medulla (RVLM) in vivo and in vitro. Repeated microinjections of NMDA (0.14 nmol) into the RVLM every 30 min caused reproducible increases in mean arterial pressure in urethane-anesthetized rats weighing 325-350 g. Intravenous injections of ethanol (0.16 or 0.32 g, 1 ml) inhibited NMDA-induced pressor effects in a blood-concentration-dependent and reversible manner. The inhibitory effect of ethanol was reduced over time during continuous infusion of ethanol or on the second injection 3.5 h after prior injection of a higher dose of ethanol (0.32 g). A high dose of ethanol (0.32 g) had no significant effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, gamma-aminobutyric acid and glycine-induced changes in blood pressure. In vitro studies showed that ethanol (10- 100 mM) dose-dependently inhibited inward currents elicited by pressure ejection of NMDA (10 mM) in RVLM neurons of neonatal brainstem slice preparations. When the superfusion time of ethanol (100 mM) was increased to 50 min, its inhibitory effect decreased gradually after 30-40 min in 60% of RVLM neurons examined. These data suggested that ethanol inhibition and subsequent tolerance development is associated with changed sensitivity to NMDA in the RVLM, which may play important roles in the ethanol regulation of cardiovascular function.

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Effect of NMDA antagonists on rapid and chronic tolerance to ethanol: Importance of intoxicated practice

Cited by 37 publications

References 26 publications

Effects of Genetic and Procedural Variation on Measurement of Alcohol Sensitivity in Mouse Inbred Strains

Effects of Genetic and Procedural Variation on Measurement of Alcohol Sensitivity in Mouse Inbred Strains

Blockade of adenosine and dopamine receptors inhibits the development of rapid tolerance to ethanol in mice

Acute tolerance to ethanol inhibition of NMDA-induced responses in rat rostral ventrolateral medulla neurons

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