Effect of Nitrous Oxide on Cerebral Blood Flow in Normal Humans

Interactions between Nitrous Oxide and Tissue Plasminogen Activator in a Rat Model of Thromboembolic Stroke

“…29 Difference between the effects of postischemic xenon and postischemic nitrous oxide on tPA-induced brain hemorrhages and disruption of the blood-brain barrier are likely to occur at the vascular, rather than the parenchymal, level. This could be because xenon has no effect or even decreases cerebral blood flow in specific brain regions at concentrations to 1 minimum anesthetic concentration, [45][46][47] whereas in contrast, nitrous oxide at concentrations as low as 0.5 minimum anesthetic concentration is well known to increase cerebral blood flow and cerebral blood flow velocity, 48,49 conditions that could favor disruption of the blood-brain barrier, particularly during reperfusion.…”

Histamine release following atracurium in the elderly

“…There have, however, been few published reports of ketorolac causing significant perioperative blood loss [2] and none of a single 30 mg dose.…”

Near infrared spectroscopy

“…In a recent 'state of the art' textbook on transcranial Doppler [l], it was stated by Aaslid that use of systolic rather than mean velocity gives more reliable data. Field et al [2] give data which suggest that cerebral blood flow measured using xenon uptake correlates inversely with the pulsatility index (systolic velocity-diastolic velocity/mean velocity). Finally, Harris and Bailey suggest in their discussion that hypercapnia increases the diameter of the middle cerebral artery, implying that there is in fact an even greater increase in cerebral blood flow than is suggested by the increase in flow velocity which they documented.…”