Effect of nitroso-redox imbalance on male reproduction

Kuchakulla, Manish; Masterson, Thomas A.; Arora, Himanshu; Kulandavelu, Shathiyah; Ramasamy, Ranjith

doi:10.21037/tau.2018.08.14

Cited by 13 publications

(9 citation statements)

References 76 publications

(89 reference statements)

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“…In the testis, oxidative stress impairs the steroidogenic capacity of Leydig cells and the differentiation capacity of the germinal epithelium [ 26 ]. Furthermore, nitrosative stress alone or in combination with oxidative stress, has been associated with pathologic aftermaths in the male reproductive organs [ 27 , 28 ]. During the initiation of spermatogenesis and the epididymal maturation, the reproductive organs deploy preventive antioxidant enzymes such as SOD, CAT and GPx to counteract internally generated reactive oxygen species [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Histomorphological and Redox Delineations in the Testis and Epididymis of Albino Rats Fed with Green-Synthesized Cellulose

Otuechere

Adewuyi

Adebayo

et al. 2020

Biology

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It has also become increasingly necessary to diversify the production of cellulose for biomedical applications. In this study, cellulose-green-synthesized from Sesamum indicum (GSC)—was administered orally to rats for 14 days as follows: control, 100, 200 and 400 mg/kg GSC. The impact of GSC on the antioxidant status and histomorphology of the testes and epididymis were studied. GSC had no effects on organ weights and organosomatic indices. In the testes, GSC caused nonsignificant changes in superoxide dismutase, catalase, reduced glutathione and nitric oxide levels, whereas it significantly decreased glutathione peroxidase and malondialdehyde levels. In the epididymis, GSC significantly decreased superoxide dismutase and nitric oxide levels, but caused a significant increase in glutathione peroxidase and reduced glutathione levels. Furthermore, at ×200 magnification, testicular morphology appeared normal at all doses, however, extravasation of the germinal epithelium of the epididymis was observed at doses of 200 and 400 mg/kg GSC. Conversely, at ×400 magnification, spermatogenic arrest (testes) and chromatolytic alterations (epididymis) were observed at the higher doses (200 and 400 mg/kg GSC). This study reports on the effect of green-synthesized cellulose on testicular and epididymal histology and redox status and further extends the frontiers of research on cellulose.

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Section: Discussionmentioning

confidence: 99%

Histomorphological and Redox Delineations in the Testis and Epididymis of Albino Rats Fed with Green-Synthesized Cellulose

Otuechere

Adewuyi

Adebayo

et al. 2020

Biology

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“…As NO half-life in vivo is in the order of a few seconds, this reaction might be dependent on its initial concentration [ 74 ], thus making it potentially problematic in the context of NO supplementation where a bolus of NO 3 − is ingested at once without the presence of other ingredients affecting its digestion. In this context, a major concern might be the interaction between NO and superoxide (O 2 ) leading to peroxynitrite (OONO − ) formation—a highly reactive nitrogen species (RNS) affecting mitochondrial function, signal transduction, and stress response [ 75 , 76 ]. Chronic OONO − formation might directly lead to the production of RNS and reactive oxygen species (ROS) in other subcellular compartments, leading to increased oxidative stress [ 77 ], which might affect performance.…”

Section: Nitrates and Exercise Performancementioning

confidence: 99%

Effects of Nitrate Supplementation on Exercise Performance in Humans: A Narrative Review

Macuh

Knap

2021

Nutrients

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Nitrates have become increasingly popular for their potential role as an ergogenic aid. The purpose of this article was to review the current scientific evidence of nitrate supplementation on human performance. The current recommendation of nitrate supplementation is discussed, as well as possible health complications associated with nitrate intake for athletes, and dietary strategies of covering nitrate needs through sufficient intake of nitrate-rich foods alone are presented. Pubmed, Scopus, and Web of Science were searched for articles on the effects of nitrate supplementation in humans. Nitrates are an effective ergogenic aid when taken acutely or chronically in the range of ~5–16.8 mmol (~300–1041 mg) 2–3 h before exercise and primarily in the case of exercise duration of ~10–17 min in less trained individuals (VO2max < 65 mL/kg/min). Nitrate needs are most likely meet by ingesting approximately 250–500 g of leafy and root vegetables per day; however, dietary supplements might represent a more convenient and accurate way of covering an athlete’s nitrate needs. Athletes should refrain from mouthwash usage when nitrate supplementation benefits are desired. Future research should focus on the potential beneficial effects of nitrate supplementation on brain function, possible negative impacts of chronic nitrate supplementation through different nitrate sources, and the effectiveness of nitrate supplementation on strength and high-intensity intermittent exercise.

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“…A high correlation has been found between 8-OHdG level, the main marker of DNA oxidative stress, and sperm DNA fragmentation, but a clear relationship between the two remains to be defined (Tamburrino et al, 2012). Moreover, the hydroxyl radical (HO⋅), the most reactive species, has been found to potentially induce double-stranded DNA damage in spermatozoon indirectly through sperm caspase and endonuclease activation (Chatterjee & Walker, 2017;González-Marín, Gosálvez, & Roy, 2012;Kuchakulla, Masterson, Arora, Kulandavelu, & Ramasamy, 2018).…”

Section: Oxidative Stressmentioning

confidence: 99%

How defective spermatogenesis affects sperm DNA integrity

et al. 2020

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Spermatogenesis is the complex process by which spermatozoa develop in the seminiferous tubules of the testis. It is the essential component in the establishment and maintenance of male fertility. Spermatogenesis is tightly regulated by hormones and growth factors from the anterior pituitary gland or within the testes itself. The steps of spermatogenesis can be divided as follows: spermatogonial renewal and proliferation via mitosis and differentiation, cell cycle progression from type B spermatogonia to primary spermatocytes, cell cycle progression to produce secondary spermatocytes, development of spermatozoa via spermiogenesis and spermiation (spermatozoa maturation) (Cheng & Mruk, 2012).

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Effect of nitroso-redox imbalance on male reproduction

Cited by 13 publications

References 76 publications

Histomorphological and Redox Delineations in the Testis and Epididymis of Albino Rats Fed with Green-Synthesized Cellulose

Histomorphological and Redox Delineations in the Testis and Epididymis of Albino Rats Fed with Green-Synthesized Cellulose

Effects of Nitrate Supplementation on Exercise Performance in Humans: A Narrative Review

How defective spermatogenesis affects sperm DNA integrity

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