Effect of Nitrogen on Alkaloid Production in<i>Atropa acuminata</i>

Khan, M. Bashir; Harborne, Jeffrey B.

doi:10.1055/s-2006-961222

Cited by 2 publications

(1 citation statement)

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“…The effect of nitrogen fertilization has been studied in various alkaloid-producing plants. Since alkaloids contain nitrogen and are usually derived from amino acid precursors, it has generally been assumed that higher levels of nitrogen availability would lead to higher levels of alkaloids in plants . This was shown to be the case in studies done in the 1970s on crops such as tobacco ( Nicotiana spp.…”

Section: Introductionmentioning

confidence: 99%

Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by ¹H NMR

Lubbe

Choi

Vreeburg

et al. 2011

J. Agric. Food Chem.

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Narcissus bulbs contain the biologically active alkaloid galanthamine, and Narcissus is being developed as a natural source of the molecule for the pharmaceutical industry. The effect of fertilizer on galanthamine production was investigated in a field study using a (1)H nuclear magnetic resonance (NMR) metabolite profiling approach. Galanthamine was quantitated and major metabolites in the bulbs were identified. The application of standard fertilization levels of nitrogen and potassium caused a significant increase in galanthamine as compared to a control. Multivariate data analysis of the (1)H NMR data revealed that applying double the standard level of nitrogen fertilizer resulted in production of more amino acids and citric acid cycle intermediates, but not more galanthamine. The results indicated that standard levels of fertilizer currently applied in The Netherlands are sufficient for optimal galanthamine accumulation in the bulbs. This study shows how (1)H NMR-based metabolic profiling can provide insight into the response of plant metabolism to agricultural practices.

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Section: Introductionmentioning

confidence: 99%

Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by ¹H NMR

Lubbe

Choi

Vreeburg

et al. 2011

J. Agric. Food Chem.

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Effect of water stress and nitrogen fertilization on the content of hyoscyamine and scopolamine in the roots of deadly nightshade (Atropa belladonna)

Baričević

Umek

Kreft

et al. 1999

Environmental and Experimental Botany

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Effect of Nitrogen on Alkaloid Production inAtropa acuminata

Cited by 2 publications

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Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by ¹H NMR

Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by ¹H NMR

Effect of water stress and nitrogen fertilization on the content of hyoscyamine and scopolamine in the roots of deadly nightshade (Atropa belladonna)

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Effect of Nitrogen on Alkaloid Production inAtropa acuminata

Cited by 2 publications

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Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by 1H NMR

Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by 1H NMR

Effect of water stress and nitrogen fertilization on the content of hyoscyamine and scopolamine in the roots of deadly nightshade (Atropa belladonna)

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Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by ¹H NMR

Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by ¹H NMR