Effect of nitric oxide inhibition on nasal airway resistance after nasal allergen challenge in allergic rhinitis

Maniscalco, Mauro; Miceli, Sofia; Carratù, L; Higenbottam, Tim

doi:10.1046/j.1365-2362.2001.00825.x

Cited by 45 publications

(44 citation statements)

References 20 publications

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“…In patients with seasonal allergic rhinitis, nasal obstructive symptom has been induced by nasal allergen challenge (Wang et al, 1997). Application of allergen to nasal cavity also caused a significant increase in nasal airway resistance in patients with seasonal allergic rhinitis (Maniscalco et al, 2001). One possible mechanism of the nasal obstruction is thought to be a dilatation of veins in nasal mucosa, although the exact mechanism(s) is not fully understood.…”

Section: Resultsmentioning

confidence: 99%

Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Chiba

Oshita

Sakai

et al. 2007

J. Smooth Muscle Res.

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To determine an in vivo venodilatation of nasal mucosa, which is thought to be one of the causes of nasal obstruction in allergic rhinitis, venous diameters of nasal septa were directly measured in anesthetized rats. An application of antigen to nasal mucosa of sensitized rats caused an increase in diameters of mucosal veins, that is, venodilatation: the maximal response (about 20% increase in diameters) was observed at 55 min after antigen challenge. The antigen-induced increase in venous diameter of nasal mucosa was significantly inhibited by pretreatment with a cysteinyl leukotrienes (CysLTs) receptor antagonist, SR2640, and a nitric oxide (NO) synthase inhibitor, N G -monomethyl-L-arginine, indicating that CysLTs and NO might be involved in the venodilatation of nasal mucosa induced by antigen challenge. Blocking the action of CysLTs and NO might be therefore useful for the therapy of nasal obstruction in allergic rhinitis.

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Section: Resultsmentioning

confidence: 99%

Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Chiba

Oshita

Sakai

et al. 2007

J. Smooth Muscle Res.

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“…In allergic rhinitis the picture is less clear. Some groups have shown an increase in nasal NO in rhinitis [26][27][28], while others find normal values in these patients [24,29,30]. The reason for the discrepancies in studies on rhinitis is probably related to methodology.…”

Section: Discussionmentioning

confidence: 98%

Assessment of nasal and sinus nitric oxide output using single-breath humming exhalations

Maniscalco¹,

Weitzberg²,

Sundberg³

et al. 2003

European Respiratory Journal

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Nasal nitric oxide (NO) levels increase greatly during humming compared to silent exhalation. In this study, the physiological and anatomical factors that regulate NO release during humming have been characterised in 10 healthy subjects and in a model of the sinus and the nose.Single-breath humming caused a large initial peak in nasal NO output, followed by a progressive decline. The NO peak decreased in a step-wise manner during repeated consecutive humming manoeuvres but recovered completely after a silent period of 3 min. Topical nasal application of an NO synthase inhibitor reduced nasal NO by w50% but had no effect on the increase evoked by humming. Silently exhaled nasal NO measured immediately after repeated humming manoeuvres was between 5-50% lower than basal silent NO exhalation, suggesting variable continuous contribution from the sinuses to nasal NO. Among the factors known to influence normal sinus ventilation, ostium size was the most critical during humming, but humming frequency was also of importance.In conclusion, humming results in a large increase in nasal nitric oxide, which is caused by a rapid gas exchange in the paranasal sinuses. Combined nasal nitric oxide measurement with and without humming could be of use to estimate sinus ventilation and to better separate nasal mucosal nitric oxide output from sinus nitric oxide in health and disease. Eur Respir J 2003; 22: 323-329. This study was supported by a grant from the Swedish Heart-Lung Foundation, the Swedish Research Council and by a grant from University Federico II "Progetto scambi internazionali".Nitric oxide (NO) is released into the airway lumen [1], in particular in the upper airways [2][3][4]. The exact origin of NO found in nasal air and the relative contribution from different sources within the nasal airways are not known. The paranasal sinuses are major sources of NO in adult healthy subjects [5] and the concentrations in a healthy sinus may be very high, ranging 5-20 parts per million (ppm) [5]. The sinuses communicate with the nasal cavity through the ostia and the rate of gas exchange between these cavities is dependent on several factors, such as the size of the ostia, the volume of the sinus, the nasal airflow and intra-nasal pressure [6,7]. Proper ventilation is essential for maintenance of sinus integrity, and blockage of the ostium is a central event in the pathogenesis of sinusitis [8,9]. During normal ventilation, the time required to exchange all air in the sinuses is y30 min, with large inter-individual variation [7,10]. Sinus ventilation is much slower in patients with sinus disorders [10].Recently, the current authors have shown that nasal NO levels increase greatly during humming compared to normal silent nasal exhalation, probably by speeding up the sinus gas exchange, thereby increasing nasal NO output [11]. In a twocompartment model of the nose and sinus the authors demonstrated that pulsating airflow, created by humming, causes a dramatic increase in gas exchange between these cavities [11].In the ...

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“…The utility of nNO in the diagnosis and management of allergic rhinitis has been extensively studied (Struben et al 2006a). Concentrations of nNO seem to be elevated in allergic rhinitis, compared with controls, by way of increased expression of inducible NO synthase (Arnal et al 1997;Kharitonov et al 1997;Yuksel et al 2008), although some studies have not found a significant difference (Henriksen et al 1999;Maniscalco et al 2001). Levels of nNO have been correlated with IL-5 values and the duration of the disease in patients with allergic rhinitis (Profita et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, nNO was increased during the pollen season and after allergen challenge and decreased after treatment with intranasal corticosteroids (Kharitonov et al 1997). However, other studies reported no significant increase in nNO in patients with allergic rhinitis (Henriksen et al 1999), even after allergen challenge (Maniscalco et al 2001). These seemingly conflicting data on nNO levels in allergic rhinitis may be due to difference in the subjects studied and definitions of cases.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Nasal Nitric Oxide Is Useful for the Diagnosis of Sinusitis-Induced Prolonged Cough

Kim

Jeong

Kwak

et al. 2011

Tohoku J. Exp. Med.

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Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration of nitric oxide in nasal cavity air (nNO) is influenced by allergic rhinitis and/or sinusitis, both of which are common causes of UACS. We measured nNO levels in patients with UACS and those with other causes. We also examined the usefulness of measuring nNO for differentiating patients with sinusitis from those without sinusitis. The study included 93 adult patients with prolonged cough lasting more than three weeks. Etiologies of cough were identified and nNO was measured at the initial investigation. UACS was diagnosed in 58 patients (62.4%), and sinusitis was identified in 11 (19.0%) of the 58 patients with UACS. Levels of nNO in UACS did not differ from non-UACS etiologies (316.2 ± 129.2 vs. 334.9 ± 88.2 ppb; p = 0.452), suggesting that the measurement of nNO could not discriminate UACS from other etiologies of prolonged cough. However, patients with sinusitis showed significantly decreased nNO levels (190.1 ± 114.8 ppb) compared with patients with UACS without sinusitis (345.7 ± 114.6 ppb; p < 0.001) and non-UACS patients (334.9 ± 88.2 ppb; p < 0.001). In a receiver operating characteristic curve analysis for the diagnosis of sinusitis in prolonged cough, the best sensitivity (73.2%) and specificity (81.8%) were obtained with a nNO cutoff value of 279.0 ppb. These findings imply that the measurement of nNO could be useful for diagnosis of prolonged cough associated with sinusitis.

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Effect of nitric oxide inhibition on nasal airway resistance after nasal allergen challenge in allergic rhinitis

Abstract: The results indicate that nasal administration of a NOS inhibitor L-NAME, at doses capable of decreasing nasal NO levels, has no effect on NAR and it does not prevent the NAR increase induced by an acute challenge with allergen in subjects with seasonal rhinitis.

Cited by 45 publications

References 20 publications

Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Assessment of nasal and sinus nitric oxide output using single-breath humming exhalations

Measurement of Nasal Nitric Oxide Is Useful for the Diagnosis of Sinusitis-Induced Prolonged Cough

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