Effect of night symptoms and disease severity on subjective sleep quality in children with non‐cystic‐fibrosis bronchiectasis

Erdem, Ela; Ersu, Refika; Karadağ, Bülent; Karakoç, Fazilet; Gökdemir, Yasemin; Ay, Pınar; Akpınar, İhsan; Dağlı, Elif

doi:10.1002/ppul.21454

Cited by 23 publications

(26 citation statements)

References 47 publications

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“…This is, to our knowledge, the first study to investigate the prevalence of sleep disturbances and daytime sleepiness, and their relationship with QoL in adults with bronchiectasis by utilizing standardized questionnaires [9]. Although daytime sleepiness did not differ considerably from healthy subjects, the prevalence of sleep disturbances was an approximately 2-fold higher in bronchiectasis patients.…”

Section: Discussionmentioning

confidence: 79%

“…To date, the literature on this topic in bronchiectasis has been limited. A recent study [9] reported that children with bronchiectasis had a high prevalence of sleep disturbances associated with nocturnal respiratory symptoms and disease severity. However, apart from focusing on children, the sample size in their study was insufficient to warrant a conclusive finding, and the potential impact of psychological status on sleep disturbances was also unclear.…”

Section: Introductionmentioning

confidence: 99%

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Sleep Disturbances and Health-Related Quality of Life in Adults with Steady-State Bronchiectasis

Gao

Guan

et al. 2014

PLoS ONE

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BackgroundSleep disturbances are common in patients with chronic lung diseases, but little is known about the prevalence in patients with bronchiectasis. A cross sectional study was conducted to investigate the prevalence and determinants associated with sleep disturbances, and the correlation between sleep disturbances and quality of life (QoL) in adults with steady-state bronchiectasis.MethodsOne hundred and forty-four bronchiectasis patients and eighty healthy subjects were enrolled. Sleep disturbances, daytime sleepiness, and QoL were measured by utilizing the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and St. George Respiratory Questionnaire (SGRQ), respectively. Demographic, clinical indices, radiology, spirometry, bacteriology, anxiety and depression were also assessed.ResultsAdults with steady-state bronchiectasis had a higher prevalence of sleep disturbances (PSQI>5) (57% vs. 29%, P<0.001), but not daytime sleepiness (ESS≥10) (32% vs. 30%, P = 0.76), compared with healthy subjects. In the multivariate model, determinants associated with sleep disturbances in bronchiectasis patients included depression (OR, 10.09; 95% CI, 3.46–29.37; P<0.001), nocturnal cough (OR, 1.89; 95% CI, 1.13–3.18; P = 0.016), aging (OR, 1.04; 95% CI, 1.01–1.07; P = 0.009) and increased 24-hour sputum volume (OR, 2.01; 95% CI, 1.22–3.33; P = 0.006). Patients with sleep disturbances had more significantly impaired QoL affecting all domains than those without. Only 6.2% of patients reported using a sleep medication at least weekly.ConclusionsIn adults with steady-state bronchiectasis, sleep disturbances are more common than in healthy subjects and are related to poorer QoL. Determinants associated with sleep disturbances include depression, aging, nighttime cough and increased sputum volume. Assessment and intervention of sleep disturbances are warranted and may improve QoL.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Sleep Disturbances and Health-Related Quality of Life in Adults with Steady-State Bronchiectasis

Gao

Guan

et al. 2014

PLoS ONE

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“…There are several reported causes of disruption of sleep architecture in CF, including hypoxemia, cough, obstructive apneas, and pain [30,32,33]. Less is known about the impact of non-CF bronchiectasis, but one study of 54 children reported that poor sleep quality, frequent nocturnal respiratory symptoms, and obstructive sleep apnea were common [34].…”

Section: Cystic Fibrosismentioning

confidence: 99%

Respiratory medications and sleep

Bercovitch

Tsai

2012

Curr Respir Care Rep

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Respiratory physiology is affected by sleep. Patients with chronic lung disease often complain of poor sleep quality. Sleep disturbances may result from poor control of underlying lung disease, thereby disrupting sleep. Sleep disruption may result from hypoventilation resulting in worsened gas exchange. Sleep quality may also be affected by the respiratory medications used to treat certain lung diseases. These medications can have positive effects on sleep by providing better control of underlying respiratory abnormalities and therefore offering better sleep quality. These medications may also have undesirable side effects which can worsen sleep, such as hyperarousal resulting from corticosteroid use. Knowledge of medication effects on sleep is important in management of patients with underlying lung disease. As with all medications, it is important to balance potential benefits with possible negative side effects. This article discusses the effects of common medications used to treat respiratory diseases and their impact on sleep.

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“…Although BE is commonly due to cystic fibrosis (CF) in developed countries, non-CF etiologies are also common in developing countries [1,2,3]. …”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Children with Non-Cystic-Fibrosis Bronchiectasis

et al. 2014

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Background: Non-cystic-fibrosis bronchiectasis (non-CF BE) continues to be a problem in developing countries and it is therefore important to examine and assess this disease. Objectives: The aims of this prospective study were to evaluate the health-related quality of life (HRQOL) in non-CF BE children and also to assess the risk factors associated with HRQOL. Methods: Forty-two non-CF BE patients between the ages of 9 and 18 years were enrolled in the study. All recruited patients completed the generic Short-Form-36 (SF-36), the St. George's Respiratory Questionnaire (SGRQ) for disease-specific QOL scale and forms on socioeconomic status (SES). The extent and severity of CT abnormalities were evaluated by using the modified Bhalla scoring system. Association between HRQOL questionnaires and demographic variables, pulmonary function test, high-resolution CT scores and SES were evaluated. Results: SF-36 and SGRQ subscales all correlated inversely with each other (SF-36 physical component summary with SGRQ symptoms score: r = -0.466, p = 0.001, activity score: r = -0.666, p = 0.000 and impact score: r = -0.667, p = 0.000. SF-36 mental component summary with SGRQ symptoms score: r = -0.396, p = 0.005, activity score: r = -0.533, p = 0.000 and impact score: r = -0.512, p = 0.000). There was an inverse correlation between SGRQ symptoms scores and the duration of regular follow-up (r = -0.3, p = 0.04). The symptoms subscale of SGRQ correlated positively with low values for pulmonary function testing (r = -0.417, p = 0.003) and frequent antibiotic requirements (r = 0.303, p = 0.035). Conclusions: Early diagnosis and regular follow-up of children with non-CF BE is important for improving their QOL. As expected, the severity and frequency of symptoms are inversely related to the pulmonary function and the QOL scores. A disease-specific questionnaire should be developed to monitor QOL in children with non-CF BE.

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Effect of night symptoms and disease severity on subjective sleep quality in children with non‐cystic‐fibrosis bronchiectasis

Abstract: Patients with bronchiectasis have disturbed sleep associated with severity of disease. Night symptoms increase the risk of poor sleep quality. Sleep disordered breathing and sleep quality should be assessed in these patients.

Cited by 23 publications

References 47 publications

Sleep Disturbances and Health-Related Quality of Life in Adults with Steady-State Bronchiectasis

Sleep Disturbances and Health-Related Quality of Life in Adults with Steady-State Bronchiectasis

Respiratory medications and sleep

Quality of Life in Children with Non-Cystic-Fibrosis Bronchiectasis

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