Effect of Nigella sativa oil on aluminum chloride-induced testicular damage in male albino rats

Hussein, Omar; El-Ghait, Amal T. Abou; Ahmed, Salwa Fares

doi:10.1097/01.ehx.0000457045.05261.9d

Cited by 2 publications

(2 citation statements)

References 35 publications

(27 reference statements)

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“…Some of the primary spermatocytes showed shrunken nucleus, other with anirregular nuclear envelope, their cytoplasm showed small intra-and intercellular vacuoles. Also, a diminution in the number of germinal epithelium, the same findings were aggravated in the high dose treated group (G.3), these changes were in agreement with findings reported by Hussein et al (22) . Also, recorded in another study conducted in newborn male rats, BPA was administered subcutaneously (0.01, 0.1, and 5 mg/kg bw), and spermatogenesis deteriorated due to BPA exposure (23) .…”

Section: Discussionsupporting

confidence: 92%

Effect of Bisphenol A on the Testis of Offspring of White Albino Rats during Pregnancy and Lactation: (Light and Electron Microscopic Study)

Elhady¹,

Autifi²,

Gizawy³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Introduction: The synthetic industrial and biomedical chemicals suspected to threat the health of the living organisms by disrupting their endocrine systems, referred to as endocrine disrupting chemicals (EDCs). Objective: To study the effects of Bisphenol A (BPA) on the natal and postnatal testis by the light and electron microscope to make sure if it is harmful or not on the development of male reproductive organs in albino rats. Matrial and Methods: Chemical used: Bisphenol A. The daily single oral dose was (0.3 mg/kg BW./day). Experimental animals: Adult female rats in proestrus cycle were caged overnight with adult males of proven fertility (1 male / 2 females / cage) and produced neonatal male rats.The offspring rats were divided into five main groups: Group I (Control offspring group), Group II (Experimental low dose treated offspring group with Bisphenol A (0.3 mg/kg BW./day) for two weeks, Group III (Experimental high dose treated offspring group; 12 mg/kg b.w/day), Group IV (First recovery group ), Group V (Second recovery group), Results: Chronic Bisphenol A administration produced testicular toxicity leading to marked serious histological changes of the testis including the spermatogenic cells, spermatids, Sertoli cells and Leydig cells. These testicular changes increased with the high dose intake of BPA indicating its cumulative toxic effects that caused hypospermatogenesis, leading to infertility. Conclusion: Bisphenol A administration causes testicular toxicity. So, these serious complications on testicular structure should be considered when buying any canned foods or drinks, because it is used nowadays on a large scale allover the world.

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Section: Discussionsupporting

confidence: 92%

Effect of Bisphenol A on the Testis of Offspring of White Albino Rats during Pregnancy and Lactation: (Light and Electron Microscopic Study)

Elhady¹,

Autifi²,

Gizawy³

et al. 2021

The Egyptian Journal of Hospital Medicine

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“…Also, Hussein et al (2014) support the results who reported that, nigella sativa reduced the testicular ultrastructure alteration induced by aluminum chloride by inducing an antioxidant defense mechanism.…”

Section: Chlorpyrifossupporting

confidence: 90%

Possible Protective Role of Propolis and Nigella Sativa Oil against the Toxic Effects of Chlorpyrifos on the Liver and Testes of Adult Albino Rats

Mesallam

Omar

Abass

et al. 2016

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Pesticides are major contaminants of our environment. Chlorpyrifos (CPF), a broad spectrum organophosphate insecticide, is one of the most used organophosphate pesticides in domestic and industrial applications all over the world. This work was undertaken to evaluate the protective effect of propolis and nigella sativa oil against the toxic effects of Chlorpyrifos on the liver and testes of adult male albino rats. Material and methods: Eighty adult male albino rats were used in this study. They were divided into 8 equal groups: Group I (negative control group); Group II (positive control group); Group III gavaged with propolis (400mg/Kg b. w.); Group IV gavaged with nigella sativa oil (100 mg/Kg b.w.); Group V with CPF 6.75 mg/ Kg b. w. / (1/20 of the oral LD50); while group VI gavaged with propolis and CPF, group VII gavaged with nigella sativa oil and CPF, and group VIII gavaged with both propolis and nigella sativa oil and CPF in the same previous doses. All treatments were given by oral gavage once daily for 12 weeks. Blood samples were obtained for assessment of total antioxidant capacity (TAC). Liver and testicular specimens were obtained for assessment of malondialdehyde (MDA) and histopathological examination by light and electron microscopes. Results: CPF induced chronic toxic effects in the liver and testes which were evidenced by significant increases in hepatic and testicular MDA and significant decrease in TAC serum levels. These results were confirmed by structural and ultra-structural alterations in liver and testes of CPF treated rats. Administration of propolis or nigella sativa alone or in combination ameliorated CPF induced toxic effects, but the most remarkable effects were observed in rats treated with combination of Propolis and nigella sativa. Conclusion: Combination of propolis and nigella sativa had marked protective effects against CPF-induced toxicity in liver and testes of adult albino rats.

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Effect of Nigella sativa oil on aluminum chloride-induced testicular damage in male albino rats

Cited by 2 publications

References 35 publications

Effect of Bisphenol A on the Testis of Offspring of White Albino Rats during Pregnancy and Lactation: (Light and Electron Microscopic Study)

Effect of Bisphenol A on the Testis of Offspring of White Albino Rats during Pregnancy and Lactation: (Light and Electron Microscopic Study)

Possible Protective Role of Propolis and Nigella Sativa Oil against the Toxic Effects of Chlorpyrifos on the Liver and Testes of Adult Albino Rats

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