Effect of Nigella Sativa oil versus metformin on glycemic control and biochemical parameters of newly diagnosed type 2 diabetes mellitus patients

Moustafa, Hebatallah Ahmed Mohamed; Wakeel, Lamia Mohamed El; Halawa, Mohamed Reda; Sabri, Nagwa Ali; El-Bahy, Alshaymaa Zaki; Singab, Abdel Nasser B.

doi:10.1007/s12020-019-01963-4

Cited by 33 publications

(35 citation statements)

References 35 publications

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“…Nigella sativa was inferior to metformin in terms of lowering FPG, 2 h postprandial glucose, and A1C. However, NS was comparable to metformin in lowering the body weight, waist circumference, and BMI significantly and was well tolerated with no side effects [39].…”

Section: Discussionmentioning

confidence: 87%

Amelioration of polycystic ovary syndrome-related disorders by supplementation of thymoquinone and metformin

Ammar

Salem

2021

Middle East Fertil Soc J

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Background Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of reproductive age women with a prevalence of 4-12%. The study aimed to investigate the potential benefit of adding thymoquinone to metformin in alleviating symptoms of polycystic ovarian syndrome. Two hundred seven overweight and obese PCOS patients were divided into two groups. Patients in group A received metformin 500 mg three times daily for 6 months. Patients in group B received a combination of metformin 500 mg and thymoquinone in the form of black cumin oil 500 mg capsules three times daily for 6 months. Follow-up was done after 3 and 6 months from the beginning of the study for evaluation of menstrual cycle pattern, body mass index, waist circumference, hip circumference, and waist:hip ratio, oral glucose tolerance test, glycosylated hemoglobin A1C, superoxide dismutase activity, and malondialdehyde concentration. Results Patients who received a combination of black cumin oil capsules and metformin, showed a significant decrease in number of patients suffering from amenorrhea or oligomenorrhea (P = 0.031), significant (P = 0.00) weight reduction (reduced BMI), and body fat redistribution (reduced W/H ratio), regaining oxidative balance with significant increase of SOD activity (P = 0.00) and decrease of MDA concentrations (P = 0.03). Regarding the number of prediabetic patients, there was no statistically significant difference (P = 0.89) when both groups were compared at the end of study period. Conclusions Black cumin oil supplementation constitutes a beneficial added value to metformin in ameliorating PCOS-related disorders with resumption of menstrual regularity, weight reduction, change of body fat distribution, and regaining oxidative balance.

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Section: Discussionmentioning

confidence: 87%

Amelioration of polycystic ovary syndrome-related disorders by supplementation of thymoquinone and metformin

Ammar

Salem

2021

Middle East Fertil Soc J

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“…Studies suggest a bene cial effect of N. sativa supplementation on glycemic status, especially fasting blood glucose and HbA1c [24,28]. Also, a hypolipidemic effect of N. sativa was shown by reducing verylow-density lipoprotein, triglyceride, total cholesterol, and low-density lipoprotein level [28,40,41].…”

Section: Discussionmentioning

confidence: 99%

“…Various types of plants and nutrients with health-improving properties have been identi ed due to their anti-in ammatory, lipid-lowering, anti-hypertensive and antioxidant properties, which can be potential interventions for cardiovascular disease [3,23,24]. Nigella sativa, which is also recognized as Black seed, is one of the medicinal plants that was used traditionally in the treatment of a wide range of conditions such as asthma, diarrhea, bloating [25][26][27].…”

mentioning

confidence: 99%

The Effects of Nigella Sativa Extract Oil Supplementation on Plasma Level of ICAM-1, VCAM-1, Metabolic and Oxidative Parameters and Nutritional Status in Patients With Coronary Artery Disease: Study Protocol for A Double-Blind, Randomized Controlled Trial

Tavakoli‐Rouzbehani¹,

Abbasnezhad²,

Maleki³

et al. 2020

Preprint

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Background: endothelial and metabolic dysfunction are the main risk factors for atherosclerosis, which eventually leads to cardiovascular diseases, such as coronary artery disease (CAD). However, it has been shown that increased inflammation and oxidative stress play an essential role in this process. Nigella sativa may affect declining atherosclerosis and CAD by reducing inflammation and improving vascular function.Methods: Two sections that are presented in this article include; first, a review of recent findings related to cardiovascular disease, CAD, and their association with N. sativa supplementation. Secondly, we will illustrate a randomized, double-blind clinical trial in 46 Iranian adults with CAD. The subjects (age: 35-65, proof of 50% stenosis in at least one of their major coronary arteries in angiography) will be selected by a simple random sampling method and will be assigned to two months supplementation of N. sativa extract oil or placebo group. The primary outcome is the inflammatory and oxidative variables. The secondary outcomes measures include lipid profile, quality of life, depression, and anthropometric indices. The data will be equated within and between groups using appropriate statistical methods. Discussion: The result of this trial will offer evidence about the efficacy of N. sativa supplementation by improving risk factors related to atherosclerosis and coronary artery disease. Trial registration: Iranian clinical trial registry: IRCT20190506043494N1, Date of registration: November 8, 2019.

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“…Moreover, in a randomized F I G U R E 6 Forest plot of the mean difference for the effect of NS consumption on serum SOD levels preliminary study, the twice-daily administration for 3 months of two capsules containing 500 mg of NS in patients with oral submucous fibrosis was accompanied by a significantly increase in SOD levels (Pipalia et al, 2016). On the contrary, Moustafa et al (2019) reported no significant reduction in serum TAC levels after 3 g/ day of NS administration for 3 months in type 2 diabetes mellitus patients. Furthermore, in another study recruiting epileptic children, the administration of 40-80 mg kg −1 day −1 of black seed did not change TAC and MDA levels significantly as compared to placebo (Shawki et al, 2013).…”

Section: F I G U R Ementioning

confidence: 99%

The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials

et al. 2021

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Effect of Nigella Sativa oil versus metformin on glycemic control and biochemical parameters of newly diagnosed type 2 diabetes mellitus patients

Cited by 33 publications

References 35 publications

Amelioration of polycystic ovary syndrome-related disorders by supplementation of thymoquinone and metformin

Amelioration of polycystic ovary syndrome-related disorders by supplementation of thymoquinone and metformin

The Effects of Nigella Sativa Extract Oil Supplementation on Plasma Level of ICAM-1, VCAM-1, Metabolic and Oxidative Parameters and Nutritional Status in Patients With Coronary Artery Disease: Study Protocol for A Double-Blind, Randomized Controlled Trial

The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials

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