Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial

Abstract

Background and Aims. Diabetes is a leading cause of renal failure. High levels of oxidative stress and inflammation in patients with renal diabetes lead to various disorders and mortality. This study was performed to determine the effect of Nigella sativa (NS) supplementation on superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC), high-sensitivity C-reactive protein (hs-CRP), glycosylated hemoglobin (HbA1c), fasting blood sugar (FBS), and insulin (INS) in patients with diabetes mellitus undergoing hemodialysis (HD). Methods. In this randomized, double-blind, placebo-controlled clinical trial, a total of 46 diabetic HD patients were randomly divided into NS (n = 23) and placebo (n = 23) groups. NS group received 2 g/day of NS oil, and the placebo group received paraffin oil for 12 weeks. Serum levels of SOD, MDA, TAC, hs-CRP, HbA1C, FBS, and INS were measured before and after the study. Results. Compared to baseline values, SOD, TAC, and INS levels increased, whereas MDA, hs-CRP, HbA1c, and FBS significantly decreased. After adjusting for covariates using the ANCOVA test, changes in the concentrations of SOD (p = .040), MDA (p = .025), TAC (p=<.001), hs-CRP (p = .017), HbA1c (p = .014), and FBS (p = .027) were statistically significant compared to the placebo group. Intergroup changes in INS were not significant. Additionally, there were no notable side effects during the research. Conclusions. This study found that NS supplementation significantly enhanced the levels of SOD, MDA, TAC, hs-CRP, HbA1c, and FBS in diabetic HD patients.

Nigella sativa supplementation improves cardiometabolic indicators in population with prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

“…All the included trials had parallel designs and were published between 2012 and 2022. These studies were carried out in Iran ( 19 , 21 , 37 , 41 , 43 , 45 , 46 ), India ( 40 , 44 ), Egypt ( 20 ), and Saudi Arabia ( 42 ). In total, 666 participants (338 interventions and 328 controls) were recruited with the age range between 42.9 ± 3.2 and 56 ± 3.4 years old and the BMI range between 26.79 ± 2.94 and 33.90 ± 2.10 kg/m 2 .…”

“…Numerous studies proposed N. sativa as an adjuvant therapy in diabetes control, since it revealed a significant reduction in glucose values following oral glucose tolerance test (OGTT), fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) levels, and insulin resistance, and also an escalation in serum fasting insulin concentrations ( 18 – 20 ), while recent research reported that N. sativa supplementation increased the levels of glycemic control components ( 21 ). Furthermore, it has been demonstrated that N. Sativa extract could increase the high-density lipoprotein cholesterol (HDL-C) concentration through rising the activity of plasma lecithin cholesterol acetyltransferase (LCAT), and it could also exert its antioxidant effects by enhancing the activities of antioxidant enzymes, including catalase and glutathione peroxidase, leading to its potential efficacy in amelioration of atherosclerosis ( 22 , 23 ).…”

“…Furthermore, it has been demonstrated that N. Sativa extract could increase the high-density lipoprotein cholesterol (HDL-C) concentration through rising the activity of plasma lecithin cholesterol acetyltransferase (LCAT), and it could also exert its antioxidant effects by enhancing the activities of antioxidant enzymes, including catalase and glutathione peroxidase, leading to its potential efficacy in amelioration of atherosclerosis ( 22 , 23 ). However, there are still strong pieces of evidence suggesting null effects of N. sativa on biomarkers of inflammation ( 21 , 24 ).…”

Comparison of the Effects of Abdominal Massage and Oral Administration of Sweet Almond Oil on Constipation and Quality of Life among Elderly Individuals: A Single-Blind Clinical Trial

“…In Persian medicine text book, several treatment principles are mentioned for the management of catarrh [ 20 ] and opium addiction [ 21 ]. Furthermore, a study by Rahmani et al showed that Nigella sativa oil was effective in reducing oxidative stress, inflammation, and blood sugar in diabetic patients [ 22 ].…”

Clinical Efficacy of Persian Medicine Diet Combined with Western Medicine-Based Diet on Proteinuria in Pediatric Nephrotic Syndrome: A Randomized Controlled Clinical Trial

“…Nowadays, there is a widespread tendency to use complementary and alternative medicine (CAM) therapies. It has been shown that the use of integrated methods of CAM and Western medicine can lead to better treatment results [ 11 – 18 ]. Persian medicine (PM), as one of the CAM methods, provides different strategies for the prevention and treatment of diseases.…”