Effect of Nigella sativa and Foeniculum vulgare seeds extracts on male mice exposed to carbendazim

Abstract

The increasing prevalence of environmental pollutants such as pesticides is a major global problem that affects living organisms. Exposure to environmental pollutants remains a major source of health risk throughout the world. The potential health benefits of various medicinal plants and natural products in relation to protect various diseases are currently receiving considerable attention. A current approach is to develop a new biological compound from natural products that inhibits pain. Ethnopharmacological surveys have been found to be one of the most reliable tools for the discovery of the natural and semi-synthetic drug. The present study was performed to investigate the hematological and biochemical changes induced by carbendazim (CBZ) and the potential protective effect of seeds extracts of Nigella sativa (NSSE) and Foeniculum vulgare (FVSE) against CBZ toxicity in male mice. Mice were distributed into 6 groups. Mice of group 1 were served as control. Group 2 was exposed to CBZ. Group 3 was supplemented with NSSE and exposed to CBZ. Group 4 was treated with FVSE and CBZ. Normal mice of group 5 and 6 were subjected to NSSE and FVSE respectively. Body weight gain was significantly decreased in mice of group 2. In mice of group 2, significant declines of RBC, HB, Hct, WBC, total protein, FSH, LH, testosterone, T4, T3, CAT and SOD were observed. Moreover, the levels of ALT, AST, ALP, total bilirubin, creatinine, BUN, uric acid, glucose, cholesterol, CK, LDH, MDA and GSH were significantly enhanced. Treatment with NSSE and FVSE showed attenuation effects against CBZ induced hematological and biochemical changes. The results suggest that the attenuation effects of NSSE and FVSE attributed to their antioxidant properties.

Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats

“…The restoration of functional integrity of pituitary–gonadal axis by dietary inclusion of NSS in MSG challenged rats is similar to that found in mice exposed to carbendazim 54 . This outcome may be attributed to the ability of NSS to increase the testicular steroidogenic enzymes activities 55 .…”

Effect of Nigella sativa on Testosterone Level in Albino Rats Treated with Doxorubicin

“…There was marked increase in testosterone level in A4 (treated only with Nigella sativa) as compared to groups A1, A2 and A3; this is in agreement with findings of [24,25], who reported that 2g of Nigella sativa capsules for three months significantly increases the testosterone and other reproductive hormones in humans [23,24] also support our findings.…”

“…This happens due to thymoquinone which has a key role in testicular protection due to its antioxidant, anti-apoptotic effects. It is also defensive against upper respiratory diseases, GIT disorders and skin problem [23,24,25]. This research work shows that nigella sativa has protective role against doxorubicin nephrotoxicity.…”

التأثير الوقائي لمستخلص فاکهة الکمکوات الإيثانولي ضد تسمم الکبد الناتج عن الکاربيندازيم في الفئران

“…These results are in agreement with another study (2) who found that the separated doses of CBZ resulted in a significant increase in plasma urea and creatinine. Also, rats treated with CBZ alone resulted in significant increases in serum glucose (64%), urea (99%), and creatinine (52%) levels compare with the negative group (46). Treatment rats with ethanol extract of kumquat led to dramatically lower blood glucose, urea, and creatinine levels in rats.…”