Effect of Nifedipine on Thyrotropin, Prolactin, and Thyroid Hormone Release in Man: A Placebo‐controlled Study

Abstract

Nifedipine (10 mg tid) or placebo was administered in a randomized double-blind trial for 1 wk to 2 groups of 10 mildly hypertensive euthyroid patients. Hormonal concentrations (thyrotropin [TSH], prolactin [PRL], thyroxin, triiodothyronine, and reverse triiodothyronine) before and during a TRH test were assessed in the 2 groups before (D0) and after (D7) each treatment. Parameters of the TRH test were determined (peak values, area under the curve [AUC], release [Kr], and elimination [Ke] rate constants) and their D7:D0 ratios were compared in the 2 groups. The TSH (peak values and Kr) and PRL (peak values and AUC) responses to TRH were significantly decreased in the nifedipine group compared to the placebo group. Neither basal nor TRH-stimulated thyroid hormone levels were modified. These results confirm experimental data but seem to be clinically irrelevant.

Effects of Antihypertensive Drugs on Thyroid Function in Type 2 Diabetes Patients With Euthyroidism

“…Studies indicated that CCB could interfere with thyroid function through pituitary ( Brabant et al, 1989 ; Roussel et al, 1995 ; Roussel et al, 1997 ), thyroid ( Jangid, 1993 ; Pedemonte et al, 2005 ), and peripheral thyroid physiological process ( Capen, 1994 ). However, the clinical studies on the effect of CCB on thyroid function were inconsistent ( Isles et al, 1985 ; Haitas et al, 1986 ; Valensi et al, 1989 ). The probable mechanism there was no effect on thyroid function from CCB in the current study might was another Ca 2+ pathway existing could not be prevented by CCB ( Corda et al, 1985 ) and oral treatment ( Semple et al, 1984 ).…”

“…However, the evidence for thyroid function-changing effect of second-and third-generation β 1 -adrenergic receptor blockers in euthyroid cases shows contrary outcomes (Kristensen and Weeke, 1977;Faber et al, 1979;Perret et al, 1984;Reeves et al, 1985;Kayser et al, 1991). The effect of ACEI, ARB (Hume et al, 1990;Vranckx et al, 1995;Andjelkovic et al, 2016) and CCB (Brabant et al, 1989;Jangid, 1993;Eidne et al, 1994;Roussel et al, 1995;Roussel et al, 1997;Pedemonte et al, 2005) on thyroid function were not consistent between animal study and clinical studies and the sample size was small (Isles et al, 1985;Haitas et al, 1986;Valensi et al, 1989;Andjelkovic et al, 2016).…”