Effect of Nicotine Nasal Spray on Smoking Cessation

Hjalmarson, Å.; Franzon, Mikael; Westin, Åke; Wiklund, Olov

doi:10.1001/archinte.1994.00420220059007

Cited by 123 publications

(33 citation statements)

References 11 publications

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“…The 1 year result is also low compared with the 26, 27 and 27% in the three published studies with nicotine nasal spray [10,11,19]; however, it has to be remembered that our sample of smokers are failures from 1-2 earlier studies and, thus, should be regarded as "hardcore" smokers.…”

Section: Discussionmentioning

confidence: 72%

“…The possible role of nasal aerosols in smoking cessation have been sparsely examined [6][7][8][9]. The NNS is the nicotine delivery system most closely like smoking cigarettes, due to the fast nicotine absorption from the nasal mucosa.In two well-designed, controlled trials of NNS, comprising 227 and 248 smokers, the 1 year outcomes were 26 and 27% in the active group compared with 10 and 15% in the placebo groups [10,11]. In one study, a nicotine substitution of 40% of the smoking level was attained after 1 month of NNS use and 79% after 1 year [10].…”

mentioning

confidence: 99%

“…In two well-designed, controlled trials of NNS, comprising 227 and 248 smokers, the 1 year outcomes were 26 and 27% in the active group compared with 10 and 15% in the placebo groups [10,11]. In one study, a nicotine substitution of 40% of the smoking level was attained after 1 month of NNS use and 79% after 1 year [10].…”

mentioning

confidence: 99%

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Recycling of hard-core smokers with nicotine nasal spray

Tønnesen¹,

Mikkelsen²,

Nørregaard³

et al. 1996

Eur Respir J

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The primary aim of this smoking cessation study was to evaluate the effect of long-term treatment with nicotine nasal spray in a group of hard-core smokers. A further aim was to compare the effect of ad libitum with fixed dosage of nasal nicotine spray.Eighty nine smokers, failures from two earlier studies with nicotine patches, were enrolled in an open smoking cessation study with nicotine nasal sprays, to be used ad libitum (n=45) or on a fixed schedule of 1 mg·h -1 during the day (n= 44).Carbon monoxide-verified continuous abstinence from smoking beyond Week 2, was 39% at 3 weeks, 12% at 3 months, 10% at 6 months and 6% after 1 yr, with no significant difference in success rate between ad libitum and fixed dosing. Mean daily nicotine dose was 15-16 mg during the first 3 months (range 2-65 mg). Tolerance to local irritating side-effects of nicotine developed during the first weeks of use.Although short-term outcome was promising, the long-term success rate in this group of hard-core smokers was low. Other recycling set-ups are warranted, which might include more aggressive nicotine dosing. Eur Respir J., 1996Respir J., , 9, 1619 To attain an acceptable long-term success rate in smoking cessation, some basic principles have to be followed. The most important is that from the target quit day the smokers have to quit cigarettes completely; even a single cigarette on a few occasions ("slips") will probably lead to relapse.The role of nicotine replacement with nicotine chewing gum and transdermal patches in smoking cessation has been established through several placebo-controlled clinical trials [1,2], and a doubling of the success rate can be expected [3,4]. The dose and the duration of nicotine replacement therapy has not been fully evaluated, though a duration of 6-12 weeks is recommended in most studies, and dose-response effects have been found for nicotine gum and patch [3]. The easiest nicotine product to use is the patch; when applied to the skin it releases about 1 mg of nicotine per hour, i.e. a fixed dosing system. Nicotine nasal spray (NNS), inhaler and gum have to be used ad libitum or prescribed to be taken every hour or so, with the possibility of self-regulating the dose when needed.Trials comparing the four different nicotine formulations have not been performed. In a meta-analysis, comprising 17,703 subjects and 42 gum studies, nine patch studies, one NNS and one inhaler study, the odds rates of nicotine therapy compared with controls were 1.61 for gum, 2.07 for patch, 2.92 for NNS and 3.05 for inhaler [5]. The possible role of nasal aerosols in smoking cessation have been sparsely examined [6][7][8][9]. The NNS is the nicotine delivery system most closely like smoking cigarettes, due to the fast nicotine absorption from the nasal mucosa.In two well-designed, controlled trials of NNS, comprising 227 and 248 smokers, the 1 year outcomes were 26 and 27% in the active group compared with 10 and 15% in the placebo groups [10,11]. In one study, a nicotine substitution of 40% of the smoking l...

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Section: Discussionmentioning

confidence: 72%

mentioning

confidence: 99%

See 1 more Smart Citation

Recycling of hard-core smokers with nicotine nasal spray

Tønnesen¹,

Mikkelsen²,

Nørregaard³

et al. 1996

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…34,35 Eficacia. El promedio de abstinencia a seis meses, de tres estudios [35][36][37] [39][40][41][42] fue de 24%, en tanto que el promedio de abstinentes de los que usaron placebo fue de 12.5%. En uno de los estudios 42 la diferencia entre el spray activo y el placebo no fue estadística-mente significativa.…”

Section: Goma De Polacrilex (Chicle De Nicotina)unclassified

Tratamientos para dejar de fumar, disponibles en México

Sansores¹,

Ramírez‐Venegas²,

Espinosa-Martínez³

et al. 2002

Salud pública Méx

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“…The e¦cacy of nicotine gum (Cepeda-Benito 1993) and nicotine nasal spray (Sutherland et al 1992;Hjalmarson et al 1994;Schneider et al 1995) as aids to smoking cessation have been well established. Nicotine nasal spray appears to work better than placebo in more heavily dependent smokers, even though the blood nicotine levels are relatively low compared to those while smoking (Sutherland et al 1992;Hjalmarson et al 1994;Schneider et al 1995;Hurt et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Temporal effects of nicotine nasal spray and gum on nicotine withdrawal symptoms

et al. 1998

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Nicotine nasal spray and nicotine gum have been found to be effective in relieving nicotine withdrawal symptoms. In this randomized single-blind study, 91 cigarette smokers were randomly assigned to a single 1 mg dose of active nicotine nasal spray (n=29), active 4 mg nicotine gum (n=31), saline placebo nasal spray (n=16) or placebo gum (n=15). Following overnight abstinence, subjects repeatedly completed visual analog scales for assessing nicotine withdrawal symptoms over 30 min preceding (time -30 min to time 0) and 120 min following a single dose of study medication. This sequence was performed 3 times during the day. Nicotine withdrawal symptoms were assessed on a 41-point visual analog scale (1=no withdrawal, 41=extreme withdrawal). At the initial session only, blood samples for serum nicotine levels were taken at baseline, then at 5, 10, 30 and 120 min following study drug administration. The mean (+/-SD) age of the subjects was 38.6 (+/-10.1) years, 48% were females, smoking rate was 24.5 (+/-7.8) cigarettes per day, and years of smoking was 19.9 (+/-10.0). A single 1 mg dose of nicotine nasal spray provided more immediate relief for craving for a cigarette compared to a single 4 mg dose of nicotine gum. Serum venous nicotine levels for the active nicotine nasal spray and nicotine gum were comparable at 5 and 10 min while the levels were higher for nicotine gum at 30 and 120 min. Changes in withdrawal symptoms were not found to be related to serum venous nicotine levels. Our findings provide a rationale for the as needed use of nicotine nasal spray to control withdrawal symptoms, possibly in combination with other medications with longer acting effects.

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Effect of Nicotine Nasal Spray on Smoking Cessation

Abstract: Nicotine nasal spray in combination with group treatment is an effective aid to smoking cessation.

Cited by 123 publications

References 11 publications

Recycling of hard-core smokers with nicotine nasal spray

Recycling of hard-core smokers with nicotine nasal spray

Tratamientos para dejar de fumar, disponibles en México

Temporal effects of nicotine nasal spray and gum on nicotine withdrawal symptoms

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