Effect of nicorandil on short-term echocardiographic and acute angiographic outcomes in acute coronary syndrome patients undergoing percutaneous coronary intervention

Jha, Ashish; Rohit, Manoj Kumar

doi:10.4103/heartindia.heartindia_19_20

Cited by 1 publication

(2 citation statements)

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“…24 A study conducted in India also revealed comparable results to our findings as they used nicorandil infusion two hours before PCI and continued for 48 hours after PCI and results were compared on basis of TIMI scoring and other angiographic parameters with control group and it had trend toward improvement in NRP but it could not reach statistical significance because of small sample size of only 42 patients. 25 Intravenous nicorandil caused relative significant hypotension. To prevent this fatal outcome in PCI, researchers started using this drug orally side by side which led to many significant studies and their results.…”

Section: Discussionmentioning

confidence: 99%

“…A study conducted in India also revealed comparable results to our findings as they used nicorandil infusion two hours before PCI and continued for 48 hours after PCI and results were compared on basis of TIMI scoring and other angiographic parameters with control group and it had trend toward improvement in NRP but it could not reach statistical significance because of small sample size of only 42 patients. 25 …”

Section: Discussionmentioning

confidence: 99%

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Cardio protective effect of nicorandil in reperfusion injury among patients undergoing primary percutaneous coronary intervention

et al. 2022

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Objectives: To evaluate the effect of nicorandil in prevention of reperfusion injury during primary percutaneous coronary intervention by thrombolysis in myocardial infarction flow grade scoring. Methods: A total of 140 patients from Rawalpindi Institute of Cardiology were enrolled in this study conducted from 7th September to 10th of October 2021. These participants were allocated into two major groups. Control group received conventional acute coronary syndrome protocol regimen only whereas experimental group was given nicorandil along with conventional acute coronary syndrome protocol. During primary percutaneous coronary intervention, thrombolysis in myocardial infarction flow grade scoring was analyzed and compared. Results: Majority of participants in nicorandil group achieved thrombolysis in myocardial infarction Grade-3 scoring which indicated reduced rate of no reflow phenomenon as compared to control group. A statistically significant difference was noted in score of both groups (p value = 0.001) signifying prophylactic use of nicorandil before primary percutaneous coronary intervention along with conventional acute coronary syndrome protocol is superior to only conventional acute coronary syndrome protocol regimen to cases in the control group. Conclusion: Use of nicorandil in ST elevated myocardial infarction patients before primary percutaneous coronary intervention prevents reperfusion injury thus decreasing the risk of post percutaneous coronary intervention complications and reducing mortality rate in cardiac patients suggesting its significant cardio protective role. doi: https://doi.org/10.12669/pjms.39.1.6034 How to cite this: Ilyas M, Noor M, Khan HS, Haroon S, Farhat K, Ali S. Cardio protective effect of nicorandil in reperfusion injury among patients undergoing primary percutaneous coronary intervention. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6034 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%