Effect of nickel on red blood cell parameters and on serum vitamin B12, folate and homocysteine concentrations during pregnancy with and without anemia

Pieczyńska, Joanna; Płaczkowska, Sylwia; Sozański, Rafał; Skórska, Katarzyna; Sołtysik, Martyna

doi:10.1016/j.jtemb.2021.126839

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…The effects of Ni on erythropoiesis are still under investigation. Some studies have shown that Ni-induced hypoxemia leads to an increase in the number of RBCs, although other studies have shown opposite results [ 28 , 29 , 30 ]. In our study, Ni was negatively correlated with Hgb, MCV and MCHC in the female participants.…”

Section: Discussionmentioning

confidence: 99%

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram

Huang

Wang

Chen

et al. 2021

IJERPH

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This study aimed to investigate gender differences in the association between heavy metals and hemograms including hemoglobin (Hgb), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC). A health survey of 2447 participants was conducted in southern Taiwan between June 2016 and September 2018. Seven heavy metals were measured: blood lead (Pb), urine nickel (Ni), urine chromium (Cr), urine manganese, urine arsenic (As), urine copper and urine cadmium (Cd). The results show that in females, Pb and Ni were significantly negatively associated with Hgb. In addition, As and Cd were significantly positively, and Pb and Ni were significantly negatively, associated with MCV, in males and females, respectively. The interactions between gender and Ni and gender and Cd in MCV were statistically significant. Further, Pb, in males, and Pb, Ni and Cr, in females, were significantly negatively associated with MCHC. In conclusion, in females, associations of red blood cell (RBC) hemograms with heavy metals such as Pb and Ni were found. In males, heavy metals such as Pb, As and Cd were found to associate with RBC hemograms. Further research is warranted to discuss the mechanism behind these associations.

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Section: Discussionmentioning

confidence: 99%

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram

Huang

Wang

Chen

et al. 2021

IJERPH

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“…Nickel is vital for microorganisms, plants, animals, and humans (2). Nickel deficiency can cause growth retardation and fecundity decline, impairment of specific senses, reduced iron absorption, and alteration of essential enzymes in animal tissues and organs, leading to various clinical changes (3)(4)(5). However, specific toxicity and carcinogenic properties are connected with excessive nickel.…”

Section: Introductionmentioning

confidence: 99%

Association between urinary nickel with obesity status in adults: A cross-sectional study

Wang

Huang²,

Li³

et al. 2023

Front. Public Health

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ObjectivesThe prevalence of obesity is on the rise and is connected to numerous factors. However, the relationship between obesity and nickel has never been investigated. Our study aimed to explore the association between urinary nickel and obesity Status in adults.MethodsFrom the 2017–2018 National Health and Nutrition Examination Surveys (NHANES), 1,705 participants ≥18 years of age were enrolled. To explore further the relationship among urinary nickel, body mass index (BMI), and waist circumference(WC), Weighted multivariate linear regression analyses and further subgroup analyzes were conducted.ResultsUrinary nickel does not correlate with BMI level but positively correlates with WC. In the subgroup analyzed according to sex, Urinary nickel has a positive correlation with BMI and WC in males but has a negative correlation in females. Secondary stratification analysis according to sex and race, Urinary nickel positively correlates with BMI in White males. It also positively correlates with WC in both White and Black males.ConclusionsA correlation was found between urinary nickel levels and BMI and WC in adult males. Adult men, especially those already obese, may need to reduce nickel exposure.

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“…Some studies have found that diabetic individuals who take metformin for a prolonged period are susceptible to vitamin B12 deficiency [3]. During cellular metabolism, vitamin B12 is gradually consumed by the methionine cycle, and vitamin B12 deficiency appears to be associated with an increased risk of diabetes [4]. In a multicenter randomized doubleblind controlled trial, it was found that high-dose vitamin B supplementation (folic acid, vitamin B6, and vitamin B12) significantly reduced the plasma total homocysteine level in patients with diabetic nephropathy [5].…”

Section: Introductionmentioning

confidence: 99%

Vitamin B12-Induced Autophagy Alleviates High Glucose-Mediated Apoptosis of Islet β Cells

Zhang,

Chu,

Zhou

et al. 2023

IJMS

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High glucose levels can lead to the apoptosis of islet β cells, while autophagy can provide cytoprotection and promote autophagic cell death. Vitamin B12, a water-soluble B vitamin, has been shown to regulate insulin secretion and increase insulin sensitivity. However, the precise mechanism of action remains unclear. In this study, we investigated the influence of vitamin B12 on high glucose-induced apoptosis and autophagy in RIN-m5F cells to elucidate how vitamin B12 modulates insulin release. Our results demonstrate that exposure to 45 mM glucose led to a significant increase in the apoptosis rate of RIN-m5F cells. The treatment with vitamin B12 reduced the apoptosis rate and increased the number of autophagosomes. Moreover, vitamin B12 increased the ratio of microtubule-associated protein 1 light chain 3 beta to microtubule-associated protein 1 light chain 3 alpha (LC3-II/LC3-I), while decreasing the amount of sequestosome 1 (p62) and inhibiting the phosphorylation of p70 ribosomal protein S6 kinase (p70S6K) under both normal- and high-glucose conditions. The additional experiments revealed that vitamin B12 inhibited high glucose-induced apoptosis. Notably, this protective effect was attenuated when the autophagy inhibitor 3-methyladenine was introduced. Our findings suggest that vitamin B12 protects islet β cells against apoptosis induced by high glucose levels, possibly by inducing autophagy.

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Effect of nickel on red blood cell parameters and on serum vitamin B12, folate and homocysteine concentrations during pregnancy with and without anemia

Cited by 9 publications

References 30 publications

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram

Association between urinary nickel with obesity status in adults: A cross-sectional study

Vitamin B12-Induced Autophagy Alleviates High Glucose-Mediated Apoptosis of Islet β Cells

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