Effect of new hydrophobic modification of hyaluronan on its solution properties: evaluation of self-aggregation

New amphiphilic hyaluronan derivatives based on modification with alkenyl and aryl succinic anhydrides

“…In addition, the OSA modification also introduces an additional carboxylic acid moiety that will reduce the hydrophobic character of the side chain and the hydrophobic chain has an unsaturated bond giving a different packing then a straight alkyl-chain. The CAC is the concentration when the water surface is saturated with polymer and further addition leads to formation of micelles (Chytil & Pekař, 2009). The property that micelles are formed is an important characteristic that can be exploited in drug-delivery systems for therapeutical agents that are poorly soluble in water.…”

“…5, the CAC was determined to 25 g/L (equals to 8.5 × 10 −4 mol/L when using the determined weight average molecular weight of 30,000 g/mol) with a surface tension of 42.1 mN/m. For comparison, a HA of 840,000 g/mol modified with C 8 hydrophobic chain (DS 18.8%), linked by a carbamate bond, was determined to have a CAC of 6.5 × 10 −7 mol/L and surface tension of 31.8 mN/m in 0.1 M NaCl (Chytil & Pekař, 2009). The reason for OSA-HA having a higher CAC is probably that the MW is only 1/28 part of the MW compared to the HA modified by the C 8 -carbamate and therefore had a much higher critical overlap concentration.…”

“…& Pekař, 2009;Chytil et al, 2010;Duval-Terrié, Huguet, & Miller, 2003;Gang-Biao, Daping, Kairong, & Haihua, 2006;Jeong, Kang, Yang, Park, & Kim, 2005).…”

Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma

“…Glutathione (GSH) is known as the primary endogenous antioxidant, and plays a key role in neutralization of intracellular ROS by direct and indirect scavenging [ 42 ]. As the synthesis of GSH is mainly relied on L-cysteine [ 43 ], and N -acetyl-L-cysteine (NAC) is the acetylated variant (a precursor) of L-cysteine [ 44 ], NAC can be used to provide L-cysteine for GSH production. Here, NAC was used to investigate the role of ROS achieved by Nano-FdUMP in the induction of apoptosis (fig.…”

Aggregation behavior of N-carboxyethylchitosan in aqueous solution: effects of pH, polymer concentration, and presence of a gemini surfactant

“…42,43 The concentration dependence of viscosity is illustrated in Figure 5, and it is shown that the viscosity increases linearly with the CECh concentration at both pH 4 and 10. It is understood that the intermolecular association is enhanced as the polymer concentration increases.…”