Effect of neuropeptide Y on GnRH-induced LH release from bovine anterior pituitary cell cultures derived from heifers in a follicular, luteal or ovariectomized state

Denniston, D.J.; Thomas, M. G.; Kane, K. K.; Roybal, C.N.; Canales, Lidia; Hallford, D. M.; Remmenga, Marta D.; Hawkins, D. E.

doi:10.1016/s0378-4320(03)00044-7

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…Recently, leptin , or the obese gene product, has been implicated in the interaction between nutrition and fertility in high yielding dairy cows (Keisler et al. 1999; Denniston et al. 2003; Liefers et al.…”

Section: Adverse Effects Of a Negative Energy Balance On Oocyte Qualitymentioning

confidence: 99%

Reduced Fertility in High‐yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I  The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High‐yielding Dairy Cows*

Leroy

Opsomer

Soom

et al. 2008

Reprod Domestic Animals

185

125

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Fertility in high yielding dairy cows is declining, and there is increasing evidence to presume that oocyte and embryo quality are major factors in the complex pathogenesis of reproductive failure. In this report we present an overview of possible mechanisms linking negative energy balance (NEB) and deficiencies in oocyte and embryo developmental competence; specifically, in the high producing dairy cow. Changes in follicular growth patterns during a period of NEB can indirectly affect oocyte quality. The endocrine and biochemical changes, which are associated with NEB, are reflected in the microenvironment of the growing and maturing female gamete, and likely result in the ovulation of a developmentally incompetent oocyte. Even after an oocyte is successfully ovulated and fertilized, a full-term pregnancy is still not guaranteed. Inadequate corpus luteum function, associated with reduced progesterone, and probably also low insulin-like growth factor concentrations, can cause a suboptimal microenvironment in the uterus that is incapable of sustaining early embryonic life. This may partly account for the low conception rates and the high incidence of early embryonic mortality in high yielding dairy cows.

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Section: Adverse Effects Of a Negative Energy Balance On Oocyte Qualitymentioning

confidence: 99%

Reduced Fertility in High‐yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I  The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High‐yielding Dairy Cows*

Leroy

Opsomer

Soom

et al. 2008

Reprod Domestic Animals

185

125

View full text Add to dashboard Cite

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“…Even though it remains unclear as to the exact mechanism through which NPY influenced hypothalamic-release of GHRH in the animal model used in this study, it appears that the site of action may be within the hypothalamus. In previous studies, NPY had no direct effect on GnRH-induced release of luteinizing hormone from bovine anterior pituitary cell cultures [51]. …”

Section: Discussionmentioning

confidence: 99%

Dynamics of GHRH in third-ventricle cerebrospinal fluid of cattle: Relationship with serum concentrations of GH and responses to appetite-regulating peptides

Thomas

Amstalden

Hallford

et al. 2009

Domestic Animal Endocrinology

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Objectives were to 1) characterize the relationship of third-ventricle (IIIV) cerebrospinal fluid (CSF) concentrations of growth hormone releasing hormone (GHRH) with concentrations of GH in the peripheral circulation, and 2) assess the influence of acute administration of appetite-regulating peptides, leptin (anti-orexigenic) and neuropeptide Y (NPY; orexigenic) on release of GHRH. Six mature beef cows fitted with IIIV and jugular vein cannulae were treated intracerebroventricularly with saline, and leptin (600 μg) and NPY (500 μg) in saline, in a replicated 3 x 3 Latin square design. Third-ventricle CSF and blood were collected 10 min before and continued 220 min after treatments. Mean concentrations of GHRH and frequency of pulses after treatments were 2.2 ± 0.13 ng/mL and 1.2 ± 0.15 pulses/220 min, respectively. These measures were not influenced by treatments. Concentrations of GHRH in CSF were weakly correlated (r = 0.15; P < 0.03) with serum concentrations of GH; however, 58% of the GH pulses were preceded by a pulse of GHRH and 90% of the GHRH pulses occurred within 20 min preceding a pulse of GH. Leptin tended (P < 0.10) to suppress GH area under the curve (AUC) compared to saline. Concomitantly, NPY tended (P < 0.10) to increase GH AUC, which appeared to be a consequence of increased (P < 0.05) pulse amplitude. Infusion of NPY also increased (P < 0.05) AUC of GHRH relative to saline. No differences were detected among treatments in serum concentrations of IGF-I or its AUC. Sampling CSF from the IIIV appears to be a viable procedure for assessing hypothalamic release of GHRH coincident with anterior pituitary gland secretion of GH in cattle. These data also demonstrate the differential responsiveness of the GH axis to appetite-regulating peptides.

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“…Em animais de boa condição corporal, as concentrações séricas de hormônio luteinizante (LH) são mais elevadas que naqueles que apresentam perda de escore corporal (GIL, 2003). Em animais que passam por longos períodos de restrição alimentar, a liberação do hormônio LH pela hipófise é reduzida devido à supressão da liberação do GnRH (DENNISTON et al, 2003 Vacas com maior balanço energético positivo apresentam maior número de folículos grandes nos ovários, portanto maior potencial para produzir estradiol, hormônio que estimula o centro pré ovulatório de LH e que está associado com ovulação e luteinização (PIRES et al, 2010).…”

Section: Fatores Nutricionaisunclassified

Principais fatores que afetam a precocidade de novilhas nelores e a classificação do sistema de produção precoce: uma revisão

Andrade

Ferreira

Santos

et al. 2021

Recital

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Por muito tempo a precocidade para a raça Nelore foi uma questão-paradigma para os criadores de bovinos de corte. No entanto, nos últimos anos, muitas dessas questões vêm sendo esclarecidas, e agora, sem tantos receios como em tempos passados, pode-se dizer com segurança que a raça Nelore possui animais precoces, e a utilização e multiplicação desses genes voltados à precocidade em um rebanho são essenciais para a manutenção de uma pecuária cada vez mais rentável. Para que essa precocidade possa ser utilizada de uma forma adequada é preciso entender que ela não pode ser tratada como um fator isolado, é necessário compreender que a nutrição, o melhoramento genético e a sanidade são fundamentais para que se alcance os objetivos traçados, reduzindo assim o período de inatividade dos animais no rebanho. Diante do exposto, este trabalho tem como objetivo realizar uma revisão bibliográfica acerca dos principais fatores que influenciam a puberdade de novilhas Nelores, assim como caracterizar o sistema de produção precoce.

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Effect of neuropeptide Y on GnRH-induced LH release from bovine anterior pituitary cell cultures derived from heifers in a follicular, luteal or ovariectomized state

Cited by 8 publications

References 22 publications

Reduced Fertility in High‐yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I  The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High‐yielding Dairy Cows*

Reduced Fertility in High‐yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I  The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High‐yielding Dairy Cows*

Dynamics of GHRH in third-ventricle cerebrospinal fluid of cattle: Relationship with serum concentrations of GH and responses to appetite-regulating peptides

Principais fatores que afetam a precocidade de novilhas nelores e a classificação do sistema de produção precoce: uma revisão

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Effect of neuropeptide Y on GnRH-induced LH release from bovine anterior pituitary cell cultures derived from heifers in a follicular, luteal or ovariectomized state

Cited by 8 publications

References 22 publications

Reduced Fertility in High‐yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High‐yielding Dairy Cows*

Reduced Fertility in High‐yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High‐yielding Dairy Cows*

Dynamics of GHRH in third-ventricle cerebrospinal fluid of cattle: Relationship with serum concentrations of GH and responses to appetite-regulating peptides

Principais fatores que afetam a precocidade de novilhas nelores e a classificação do sistema de produção precoce: uma revisão

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Reduced Fertility in High‐yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I  The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High‐yielding Dairy Cows*

Reduced Fertility in High‐yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I  The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High‐yielding Dairy Cows*