Effect of Neostigmine at Different Levels of Mivacurium-induced Neuromuscular Blockade

Trevien, V.; Lienbart, A.; Chandon, M.; Baras, Étienne

doi:10.1097/00000542-199409001-01084

Cited by 4 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A bigger dose of anticholinesterase may have had no impact on recovery as even larger doses of edrophonium or neostigmine have been shown to have the same effect on recovery regardless of time of administration. [26][27][28] Whether or not what was observed in this study is applicable to other centrally located neuromuscular units remains to be determined. Certainly the pharmacodynamics of onset of and recovery from nondepolarizing neuromuscular blockade are different in the muscles of respiration when compared to the AP.…”

Section: Méthodementioning

confidence: 93%

Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium

Suzuki

Lien

Belmont

et al. 2003

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

P Pu ur rp po os se e: : To examine the efficacy of antagonism of rapacuronium-, mivacurium-, rocuronium-and cisatracurium-induced neuromuscular block at the laryngeal adductors (LA). M Me et th ho od ds s: :One hundred four patients were randomly assigned to one of eight study groups. They either received rapacuronium 1.5 mg·kg ) at 10% recovery of the first twitch (T1) of train-of-four (TOF) at the LA or were allowed to recover spontaneously from neuromuscular block. The effect of antagonism on speed of recovery of neuromuscular function at the LA was evaluated.R Re es su ul lt ts s: : The time to recovery to a TOF ratio of 0.9 at the LA, when compared to the spontaneous recovery group, was significantly shortened by the administration of edrophonium in patients receiving rapacuronium [19.2 ± 7.8 vs 26.2 ± 4.9 (mean ± SD) min], rocuronium (24.7 ± 14.3 vs 44.4 ± 13.0 min) and cisatracurium (24.2 ± 5.7 vs 35.1 ± 7.6 min). Edrophonium administration did not shorten complete recovery from mivacurium-induced block (15.7 ± 8.0 vs 17.6 ± 6.1 min).C Co on nc cl lu us si io on n: : Recovery from rapacuronium-, rocuronium-or cisatracurium-induced neuromuscular block to a TOF ratio of 0.9 as measured at the LA was shortened by the administration of edrophonium, when compared to spontaneous recovery. [19,2 ± 7,8 vs 26,2 ± 4,9 (moyenne ± écart type) min], le rocuronium (24,7 ± 14,3 vs 44,4 ± 13,0 min) et le cisatracurium (24,2 ± 5,7 vs 35,1 ± 7,6 min). L'administration d'édrophonium n'a pas raccourci le temps de récupération complète d'un bloc induit par le mivacurium (15,7 ± 8,0 vs 17,6 ± 6,1 min Objectif

show abstract

Section: Méthodementioning

confidence: 93%

Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium

Suzuki

Lien

Belmont

et al. 2003

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

show abstract

“…Sixteen randomized controlled studies with data from 546 patients were included . Six studies compared spontaneous recovery with both neostigmine and edrophonium reversal .…”

Section: Resultsmentioning

confidence: 99%

“…Six studies compared spontaneous recovery with both neostigmine and edrophonium reversal . Five studies compared spontaneous recovery with neostigmine reversal and five studies compared spontaneous recovery with edrophonium reversal No studies on pyridostigmine were included. The overall assessment of the risk of bias for individual studies resulted in three studies judged as high quality, 11 as acceptable and two as low (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…A total of 11 studies compared spontaneous recovery with one or more group(s) receiving neostigmine . Study characteristics, results and quality assessment are listed in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Reversal times after neostigmine were compared to spontaneous recovery and ranged from prolonged recovery time up to 13.5 minutes, to an accelerated recovery time of maximum 7.0 minutes (significant) or 8.5 minutes (non‐significant). At reversal at T 1 < 5%, three out of five studies showed prolonged mean reversal time when neostigmine had been administered.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Reversal of mivacurium‐induced neuromuscular blockade with a cholinesterase inhibitor: A systematic review

Brinch

Söderström

Gätke

et al. 2018

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Background: Mivacurium is a short-acting non-depolarizing muscle relaxant, which is hydrolyzed by butyrylcholinesterase. The neuromuscular block (NMB) can be antagonized with cholinesterase inhibitors (CHEI), but the short duration of action of mivacurium questions the need. This systematic review evaluated if the use of CHEIs (neostigmine, pyridostigmine or edrophonium) facilitates reversal of mivacurium-induced NMB. Method:Randomized controlled trials and crossover-studies comparing spontaneous recovery with CHEI reversal in patients with mivacurium-induced NMB, assessed with quantitative neuromuscular monitoring, were included. Mean time from injection of the CHEI or allowing of spontaneous recovery to an endpoint representing full recovery was used as outcome. First response to train-of-four nerve stimulation (T 1 ) described the level of NMB for administration of the CHEI. Moderate NMB refers to T 1 ≥ 5% and deeper NMB refers to T 1 < 5%. Systematic critical appraisal was performed using the Scottish Intercollegiate Guidelines Network guidelines.Overall quality assessment was done using the Grading of Recommendations Assessment, Development and Evaluation approach.Results: Sixteen studies with data from 546 patients were included. Low quality of evidence was found that neostigmine and edrophonium administered at moderate NMB accelerated recovery with up to approximately 5.5-6.5 and 6.5-9.0 minutes, respectively. At deeper NMB only edrophonium accelerated recovery. The effect of neostigmine was not clarified at deeper mivacurium-induced NMB. No studies with reversal by pyridostigmine were identified.Conclusion: Low quality of evidence supports that neostigmine and edrophonium accelerate the recovery of mivacurium-induced NMB with 5-6.5 and 6-9.0 minutes respectively, when administered at moderate NMB. At deeper NMB only edrophonium accelerated the recovery.

show abstract

Mivacurium Neuromuscular Block at the Adductor Muscles of the Larynx and Adductor Pollicis in Humans

Plaud¹,

Debaene²,

Lequeau³

et al. 1996

Anesthesiology

View full text Add to dashboard Cite

show abstract

Effect of Neostigmine at Different Levels of Mivacurium-induced Neuromuscular Blockade

Cited by 4 publications

References 0 publications

Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium

Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium

Reversal of mivacurium‐induced neuromuscular blockade with a cholinesterase inhibitor: A systematic review

Mivacurium Neuromuscular Block at the Adductor Muscles of the Larynx and Adductor Pollicis in Humans

Contact Info

Product

Resources

About