Effect of neonatally injected ACTH and ACTH analogues on eye-opening of the rat

Helm-Hylkema, H. Van Der; Wied, D. de

doi:10.1016/0024-3205(76)90144-2

Cited by 43 publications

(5 citation statements)

References 18 publications

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“…Increased adrenal weights were the only difference observed between groups among the developmental parameters we examined. Similar to the report of van der Helm-Hylkama and deWeid [38], who treated female neonates with ACTH4-10, we found no effect on data of eye opening in our male pups. Developmental activity patterns also were not altered, nor did we observe any differences in brain or body weights.…”

Section: Discussionsupporting

confidence: 92%

Neonatal exposure to a high level of ACTH4–10 impairs adult learning performance

McGivern

Rose

Berka³

et al. 1987

Pharmacology Biochemistry and Behavior

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Male offspring of Sprague-Dawley dams were injected with 25 micrograms of ACTH4-10 or the vehicle on days 2 through 7 postpartum. Peptide treated animals exhibited a marked motor response to the peptide injection. Adrenal weights of these animals were consistently heavier than littermate controls in both the developing and adult animals. ACTH4-10 treated neonates exhibited significantly poorer learning performance in the shuttle box and were slower to acquire the reversal learning problem of a visual discrimination task under light shock levels. In addition, these animals also exhibited an exaggerated startle response and a stronger thigmotaxis response in the open field than controls. These results indicate that exposing the developing nervous system to relatively high levels of ACTH4-10 can produce marked long-term effects on behavior.

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Section: Discussionsupporting

confidence: 92%

Neonatal exposure to a high level of ACTH4–10 impairs adult learning performance

McGivern

Rose

Berka³

et al. 1987

Pharmacology Biochemistry and Behavior

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“…As in previous reports (6,43), there was a trend suggesting that ~-MSH accelerated, and B-endorphin delayed eye-opening, however, the influence of litter membership compromised the main effect of treatment. Rats exposed to e-MSH in utero were heavier at day 4 (F (1,4) = 9.51, p < .05).…”

Section: Table II Presents the Results Of Prenatal Peptide Exposure O...supporting

confidence: 82%

Persisting subsensitivity of the striatal dopamine system after fetal exposure to β-endorphin

Sandman

Yessaian

1986

Life Sciences

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“…Perinatal treatment of rats with melanocortin peptides was found to result in earlier eye opening and accelerated maturation of the neuromuscular system (35,36). ␣-MSH has also been shown to enhance prostaglandin production by bovine retinal pigment epithelium (37), and it has been proposed that ␣-MSH may modulate the neuroactivity of the retina and induce increased permeability of the blood-aqueous barrier of the eye (38).…”

Section: Discussionmentioning

confidence: 98%

Melanocortin-4 Receptor Messenger Ribonucleic Acid Expression in Rat Cardiorespiratory, Musculoskeletal, and Integumentary Systems

Mountjoy

Dumont

et al. 2003

Endocrinology

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We determined melanocortin-4 receptor (MC4-R) mRNA ontogeny in the rat using in situ hybridization and a rat MC4-R riboprobe and showed numerous peripheral sites of expression for MC4-R. The developing heart showed MC4-R mRNA expression as early as embryonic day (E) 14. In the lungs of E16-E20 fetuses, the cells surrounding developing bronchi expressed relatively strong in situ signal. Muscles associated with the respiratory system such as diaphragm and intercostal muscle expressed MC4-R mRNA as early as E14. Occipital and tongue muscles, in particular the genioglossus, showed diffuse signal at E15-E20. In the eye, a discrete signal was detected in an outer neuroblastic layer which may correspond to retina or extraocular muscle. Developing limb buds expressed relatively strong signal at E14, whereas skull bone and joint capsules of the paw of the forelimb showed signal at E18-E20. Using RT-PCR and ribonuclease protection assays, we determined that MC4-R mRNA is also expressed in adult rat heart, lung, kidney, and testis. The expression of the MC4-R in cardiorespiratory, musculoskeletal, and integumentary systems supports functional roles for the MC4-R in addition to its roles in appetite, weight control, and regulation of linear growth.

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Effect of neonatally injected ACTH and ACTH analogues on eye-opening of the rat

Cited by 43 publications

References 18 publications

Neonatal exposure to a high level of ACTH4–10 impairs adult learning performance

Neonatal exposure to a high level of ACTH4–10 impairs adult learning performance

Persisting subsensitivity of the striatal dopamine system after fetal exposure to β-endorphin

Melanocortin-4 Receptor Messenger Ribonucleic Acid Expression in Rat Cardiorespiratory, Musculoskeletal, and Integumentary Systems

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