Effect of neonatal β-endorphin imprinting on sexual behavior and brain serotonin level in adult rats

Csaba, G.; Knippel, Barbara; Karabélyos, Cs; Inczefi-Gonda, Ágnes; Hantos, Mónika; Tóthfalusi, László; Tekes, Kornélia

doi:10.1016/s0024-3205(03)00254-6

Cited by 27 publications

(29 citation statements)

References 32 publications

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“…effect of the late imprinting. However, the decrease of brain serotonin level did not influence the sexual behavior of females (Table 1) in contrast to an earlier observation, when after neonatal endorphin imprinting the brain serotonin level and sexual activity paralellously decreased in females (Csaba et al, 2003b).…”

Section: Resultscontrasting

confidence: 96%

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Effect of treatment at weaning with the serotonin antagonist mianserin on the brain serotonin and cerebrospinal fluid nocistatin level of adult female rats: a case of late imprinting

et al. 2004

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Section: Resultscontrasting

confidence: 96%

“…In addition, after endorphin treatment nocistatin level of cerebrospinal fluid enormously increased without an effect on nociceptin level (Csaba et al, 2003b;Tekes et al, 2004). Endorphin treatment at weaning also reduced serotonin content of the brain and increased sexual activity of adult females .…”

Section: Introductionmentioning

confidence: 94%

Effect of treatment at weaning with the serotonin antagonist mianserin on the brain serotonin and cerebrospinal fluid nocistatin level of adult female rats: a case of late imprinting

et al. 2004

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“…20 This was the reason why the serotonin content of cells was also studied in the present experiment. Treatment at weaning also decreased mast cell serotonin content, however the difference was not fully significant (p < 0.07).…”

Section: Resultsmentioning

confidence: 64%

Effect of endorphin exposure at weaning on the endorphin and serotonin content of white blood cells and mast cells in adult rat

Csaba

Kovács

Pállinger

2004

Cell Biochemistry & Function

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Hormonal imprinting takes place perinatally at the first encounter between the developing receptor and its target hormone, resulting in the accomplishment of normal receptor development. In the presence of an excess of target hormone or the absence of it, or an excess of related molecules which can be bound by the receptor, faulty imprinting develops with life-long consequences. In previous experiments neonatal endorphin exposure caused a decrease in endorphin and serotonin content of peritoneal mast cells of adult animals. In the present experiment 25-day-old (weaned) female rats received 2 microg endorphin, and the endorphin as well as serotonin content of adult mast cells and white blood cells was studied by flow cytometry and confocal microscopy. Peritoneal lymphocytes and blood monocytes contained significantly (p<0.01) less endorphin and peritoneal mast cells less serotonin (p<0.07, i.e. of questionable significance) than the untreated control. The results bring attention to the possibility of durable imprinting of differentiating cells later in life and to the durable (possibly life-long) effect of an endorphin excess (perhaps caused by injury) manifested in the change of endorphin and serotonin content of immune cells.

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“…85 Imprinting with serotonin or endorphin influences the serotonin content of certain areas of the adult brain; 86,87 and there is also cross-imprinting. As serotonin levels of the brain are interrelated with aggression, 88,89 it can be surmised that the different neonatal endorphin levels evoked by pain during delivery can set up later aggressivity of the individual.…”

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confidence: 99%

Hormonal imprinting: phylogeny, ontogeny, diseases and possible role in present‐day human evolution

Csaba

2007

Cell Biochemistry & Function

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Hormonal (chemical) imprinting which was first observed (and named) by us in the seventies of the last century, is a general biological phenomenon which takes place when the developing receptor meets its target hormone for the first time. Under the effect of imprinting, receptors mature and reach their maximal binding capacity. It also influences the cells' hormone production and different functions depending on receptors and hormones. Hormonal imprinting is present already at the unicellular level causing the development of specific receptors and helping the easier recognition of useful or harmful surrounding molecules. The phenomenon is an important factor in the survival of the species, as the effect of imprinting is transmitted to the progeny cell generations. At the same time it possibly helps the selection of molecules which are suitable for acting as hormones in higher ranked animals. In mammals, hormonal imprinting takes place perinatally and determines the function of receptor-signal-transduction systems as well as hormone production for life. However, there are other critical imprinting periods for continuously developing cells. Excess of the target hormones or presence of foreign molecules which are able to bind to the receptors, provoke faulty imprinting in the critical periods with life-long morphological, biochemical, functional or behavioural consequences. As many receptor-bound foreign molecules are used as medical treatments and many such molecules are present around us and inside us as environmental pollutants, they--causing faulty imprinting--are able to predispose the (human) organism to cardiovascular, endocrine, metabolic and cancerous diseases. It seems likely that this effect is connected with disturbance of DNA methylation process in the critical periods of life. There are some signs of the transgenerational effect of faulty imprinting and this could be manifested in the evolution of humans by an epigenetic route.

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Effect of neonatal β-endorphin imprinting on sexual behavior and brain serotonin level in adult rats

Cited by 27 publications

References 32 publications

Effect of treatment at weaning with the serotonin antagonist mianserin on the brain serotonin and cerebrospinal fluid nocistatin level of adult female rats: a case of late imprinting

Effect of treatment at weaning with the serotonin antagonist mianserin on the brain serotonin and cerebrospinal fluid nocistatin level of adult female rats: a case of late imprinting

Effect of endorphin exposure at weaning on the endorphin and serotonin content of white blood cells and mast cells in adult rat

Hormonal imprinting: phylogeny, ontogeny, diseases and possible role in present‐day human evolution

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