2015
DOI: 10.1016/s0140-6736(14)61731-1
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Effect of neonatal vitamin A supplementation on mortality in infants in Tanzania (Neovita): a randomised, double-blind, placebo-controlled trial

Abstract: Summary Background Supplementation of vitamin A in children aged 6–59 months improves child survival and is implemented as global policy. Studies of the efficacy of supplementation of infants in the neonatal period have inconsistent results. We aimed to assess the efficacy of oral supplementation with vitamin A given to infants in the first 3 days of life to reduce mortality between supplementation and 180 days (6 months). Methods We did an individually randomised, double-blind, placebo-controlled trial of … Show more

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Cited by 63 publications
(83 citation statements)
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“…In many developing countries, including Tanzania, maternal and newborn death and morbidity are major issues, often propagated by malnourishment (3,4). Efforts to reduce infant mortality by supplementation with vitamin A have failed (5). Fermented foods, including dairy products, have long been part of tradition in many parts of the African continent.…”
mentioning
confidence: 99%
“…In many developing countries, including Tanzania, maternal and newborn death and morbidity are major issues, often propagated by malnourishment (3,4). Efforts to reduce infant mortality by supplementation with vitamin A have failed (5). Fermented foods, including dairy products, have long been part of tradition in many parts of the African continent.…”
mentioning
confidence: 99%
“…In India the newborn vitamin A supplementation showed a 6-month survival benefit (RR ¼ 0.90, 95% CI: 0.81À1.00), 61 whereas neither study in Africa showed an impact. 62,63 In the meta-analysis that was undertaken, a clear 6-month survival benefit in Asia was observed (RR ¼ 0.87, 95% CI: 0.78À0.96), whereas the pooled effect size in Africa was 1.10 (95% CI: 1.00À1.21). 64 The major difference between the two geographic regions that has been consistent is the level of maternal vitamin A deficiency in the population in which the studies were done.…”
Section: Newborn Vitamin a Supplementationmentioning
confidence: 99%
“…In Ghana, the Relative Risk Ratio (RRR) between the VAS and control group was 1.12 with 95% CI 0.95-1.33 and p-value 0.18 [31]. In Tanzania, RRR was 1.10 with 95% CI 0.95-1.26 and p-value 0.19 [16]. In India, RRR was 0.90 with 95% CI 0.81-1.0 and p-value 0.06 [32].…”
Section: Vitamin a Supplementation And Contradicting Viewpoints On Itmentioning
confidence: 99%
“…Neonatal VAS (within the first 28 days after birth) was proposed to improve infant survival by increased VA body storage. Presently, WHO does not recommend neonatal VAS due to conflicting evidence on neonatal mortality [30], which prompted large-scale trials for more conclusive evidence and better decision-making [16]. With WHO funding, three large-scale randomized trials were conducted in Ghana, Tanzania and India to assess whether an oral dose of 50,000 IU VA to newborn infants reduced post-VAS mortality by at least 15% in the first six months of life [31].…”
Section: Vitamin a Supplementation And Contradicting Viewpoints On Itmentioning
confidence: 99%