Effect of Neonatal Thymectomy on the Induction of Sarcomata in C57BL Mice

Role of Immunologic Disturbance in Human Oncogenesis: Some Facts and Fancies

“…It has also been reported that they may exhibit a shorter latent period for tumor induction bv the carcinogenic hydrocarbons, though the differences observed are not striking (Miller, Grant and Roe, 1963;Grant and Miller, 1965). Restoration of immunocompetence by the implantation of isologous thymic grafts simultaneously restores resistance to tumor induction by the oncogenic viruses (Law and Ting, 1965).…”

Unilateral development of ovarian tumour in thymectomized Swiss mice following a single injection of 7,12-dimethylbenz(a)anthracene at neonatal stage

“…This agrees with the experiment reported by Jull, Streeter and Sutherland (1966) who have shown that neoplastic transformation of ovarian tissue of adult age began within 24 hours after DMBA administration. It has been reported that immunodepression after thymectomy shows an enhancing influence on chemical carcinogenesis in the skin (Miller, Grant and Roe, 1963;Grant and Miller, 1965) and in the liver (Nishizuka, Nakakuki and Usui, 1965). It seemed clear that the increased ovarian tumour incidence was not based on this mechanism, since no significant difference in incidence was observed between the group that received adult thymectomy and the group that received thymectomy followed by thymus-grafting.…”

Some Endocrine Aspects of the Thymus Gland

“…Neonatal thymectomy has been reported to enhance the carcinogenic effects of 20-methylcholanthrene (Grant and Miller, 1962;Nishizuka, Nakakuki and Usui, 1965), and 3,4-benzopyrene (Miller, Grant and Roe, 1963). In contrast, after thymectomy no differences were found in the effects of 3-methylcholanthrene (Law, 1965) or 7,12-dimethylbenz(a) anthracene (Allison and Taylor, 1967).…”