Effect of neonatal administrations of 6-OHDA on the brain development. I. Alteration in the striatum.

Imamoto, Kikuko; Nagai, Toshisaburo; Kimura, Hiroshi; Maeda, Toshihiro

doi:10.1679/aohc1950.43.347

Cited by 7 publications

(9 citation statements)

References 34 publications

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“…As mentioned in the previous report (IMAMOTO et al, 1980), the rats treated with 6-OHDA gained body weight slowly but always remained about 30% lighter than the controls. Concerning the effects of undernutrition, HELDLEY-WHYTE and MEUSER (1971) reported the uniform reduction of myelin synthesis, thin myelin lamination, but no abnormal structures of the sheaths.…”

Section: Discussionsupporting

confidence: 72%

“…Following repeated subcutaneous injection of 6-OHDA (one dose: 100 ,ug/gbw) in neonatal rats, brain tissues were obtained in the same manner as in previous reports (IMAMOTo et al, 1980(IMAMOTo et al, , 1982. The myelin structures were examined under an electron microscope, with special reference to the regions of the mesencephalic tract of the trigeminal nerve and in the corpus callosum.…”

Section: Methodsmentioning

confidence: 99%

“…In previous papers, we have reported that 6-hydroxydopamine (6-OHDA) administration to neonatal rats caused a long-lasting reduction of catecholamine (CA) in the striatum and in the cerebral cortex and a remarkable increase of CA varicosities in the pons (IMAMOTO et al, 1980(IMAMOTO et al, , 1982. Furthermore, we stated that the long-lasting reduction of CA varicosities resulted in an appearance of membranous lamellar bodies and neuronal degeneration in the forebrain.…”

mentioning

confidence: 99%

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Effects of neonatal administrations of 6-OHDA on brain development. III. Myelin degeneration in the mesencephalic tract of the trigeminal nerve.

Imamoto

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary. In rats treated with 6-OHDA in early postnatal days, myelin degeneration was observed in large and medium-sized myelinated nerve fibers belonging to the mesencephalic tract of the trigeminal nerve. Splitting of mylin lamination at the intraperiodic line and irregular excess scrolls were frequent in these fibers, whereas the smaller sized fibers remained intact. Occasionally, naked axons with numerous neurofilaments and neurotubules appeared near the empty myelin scrolls, indicating autolysis of the once-formed myelin sheaths. Some sheaths showed decompaction through loose lamination around the axons.The perikarya of the mesencephalic neurons showed no visible damage, but dark terminals making axo-somatic synapses in the motor nucleus were regarded as degenerating features of the axon-collaterals of the mesencephalic neurons. Thus, the myelin abnormalities were partially attributed to a kind of Wallerian degeneration.A survey of the glial cells in the corpus callosum indicated no remarkable changes in the ratio of the various glial types and in the myelin structures in comparison with those of the controls, although insufficient maturation of oligodendrocytes resulted in a 5-day delay in the onset of myelinogenesis.These findings suggest that the myelin degeneration in the mesencephalic tract is a regionally specific alteration induced by 6-OHDA administrations, probably because of the abnormal accumulation of NA in this area.

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Section: Discussionsupporting

confidence: 72%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of neonatal administrations of 6-OHDA on brain development. III. Myelin degeneration in the mesencephalic tract of the trigeminal nerve.

Imamoto

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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“…In a previous report (IMAMOTO et al, 1980), we focused our attention on the alteration in the nigro-neostriatal dopamine (DA) system.…”

Section: Discussionmentioning

confidence: 99%

“…They daily received 10 subcutaneous injections of 6-OHDA in the same manner as in the previous report (one dose: 100 ~Cg/gbw, IMAMOTO et al, 1980). Thereafter, the rats survived for periods ranging from 10 to 42 days after birth.…”

Section: Methodsmentioning

confidence: 99%

Effects of neonatal administrations of 6-OHDA on brain development. II. Changes in the central noradrenaline system.

Imamoto

Nagai

Maeda

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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Glial Cells as Key Orchestrators of Neural Degeneration in Basal Ganglia Disorders

Bhaduri

Alladi

2022

The Biology of Glial Cells: Recent Advances

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Effect of neonatal administrations of 6-OHDA on the brain development. I. Alteration in the striatum.

Cited by 7 publications

References 34 publications

Effects of neonatal administrations of 6-OHDA on brain development. III. Myelin degeneration in the mesencephalic tract of the trigeminal nerve.

Effects of neonatal administrations of 6-OHDA on brain development. III. Myelin degeneration in the mesencephalic tract of the trigeminal nerve.

Effects of neonatal administrations of 6-OHDA on brain development. II. Changes in the central noradrenaline system.

Glial Cells as Key Orchestrators of Neural Degeneration in Basal Ganglia Disorders

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