Effect of Neomycin and Kanamycin Upon Intestinal Absorption*

Faloon, William W.; Paes, Igeval C.; Woolfolk, Donald I.; Nankin, H.; Wallace, Kendall B.; Haro, Expedito N.

doi:10.1111/j.1749-6632.1966.tb43008.x

Cited by 67 publications

(19 citation statements)

References 4 publications

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“…Examples where the formation of insoluble, poorly absorbed drug-bile salt complexes leads to decreased bioavailability include, among others, pafenolol, 81 tubocurarine, 82 neomycin and kanamycin, 83 and various large molecular weight antibiotics. 84 Related situations where poorly absorbed complexes are formed between the drug and components of the ingested meal include the well-known examples of tetracyline 85 and penicillamine.…”

Section: The Role Of Bile In Drug Dissolution and Solubilizationmentioning

confidence: 99%

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Charman

Porter

Mithani

et al. 1997

Journal of Pharmaceutical Sciences

535

343

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Drugs are absorbed after oral administration as a consequence of a complex array of interactions between the drug, its formulation, and the gastrointestinal (GI) tract. The presence of food within the GI tract impacts significantly on transit profiles, pH, and its solubilization capacity. Consequently, food would be expected to affect the absorption of co-administered drugs when their physicochemical properties are sensitive to these changes. The physicochemical basis by which ingested food/lipids induce changes in the GI tract and influence drug absorption are reviewed. The process of lipid digestion is briefly reviewed and considered in the context of the absorption of poorly water-soluble drugs. The effect of food on GI pH is reviewed in terms of location (stomach, upper and lower small intestine) and the temporal relationship between pH and drug absorption. Case studies are presented in which postprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment.

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Section: The Role Of Bile In Drug Dissolution and Solubilizationmentioning

confidence: 99%

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Charman

Porter

Mithani

et al. 1997

Journal of Pharmaceutical Sciences

535

343

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“…Addition of kanamycin, a cationic disaccharide antibiotic, to human bile also results in precipitation (101). Formation of an insoluble complex between a drug and a component of the luminal contents will probably result in decreased absorption of the drug.…”

Section: Physiologic Surfactants and Drug Absorptionmentioning

confidence: 99%

Mechanisms of Surfactant Effects on Drug Absorption

Gibaldi

Feldman

1970

Journal of Pharmaceutical Sciences

188

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“…Van den Bosch and Claes (32) demonstrated in vitro precipitation of deoxycholate by neomycin at a pH of 6.3, and these observations were confirmed and extended by Thompson and colleagues (9), who did in vitro studies with bile acid micelles. Faloon et al (33) showed that neomycin precipitated bile acids out of human bile in vitro, and Thompson et al (10) demonstrated that neomycin decreased the fatty acid and bile acid content of micelles in the human intestinal lumen. However, Hardison and Rosenberg (34) obtained different results: they found that during neomycin administration in three patients, bile salt and fatty acid concentrations in the duodenal micellar phase were not reduced.…”

Section: Mechanism Of Decrease In Cholesterol Absorptionmentioning

confidence: 99%

Effects of neomycin on absorption, synthesis, and/or flux of cholesterol in man.

Sedaghat¹,

Samuel²,

Crouse³

et al. 1975

J. Clin. Invest.

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A B S T R A C T The mode of action of the hypocholesteremic drug neomycin (2 g/day) was studied in four patients. All showed a significant reduction in plasma cholesterol concentrations (mean 25%, range (1), and since then it has been demonstrated that a few other antibacterial drugs have similar properties. Of these kanamycin (2) and paromomycin (3) are similar in structure to neomycin, but chlortetracycline (2), chloramphenicol (4), and para-aminosalicylic acid (2) have markedly different molecular conDr. Sedaghat's present address is:

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Effect of Neomycin and Kanamycin Upon Intestinal Absorption*

Cited by 67 publications

References 4 publications

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Mechanisms of Surfactant Effects on Drug Absorption

Effects of neomycin on absorption, synthesis, and/or flux of cholesterol in man.

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