Effect of negative pressure wound therapy on wound healing

Huang, Chenyu; Leavitt, Tripp; Bayer, Lauren R.; Orgill, Dennis P.

doi:10.1067/j.cpsurg.2014.04.001

Cited by 395 publications

(336 citation statements)

References 103 publications

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“…The associated complications include hemorrhage, blistering, odors, skin erosion around the suction tube, sepsis and obstruction of the suction tube (33). A number of the aforementioned complications, although rarely observed, may be severe; thus, close observation and assessment of the wound throughout the entire process of NPWT is necessary.…”

Section: Discussionmentioning

confidence: 99%

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

Chen

et al. 2016

Oncology Letters

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Abstract. Major wound complications of the extremities, following wide tumor resection and reconstruction for soft-tissue sarcomas (STSs), remain a challenge for limb-sparing surgery. Furthermore, STSs with ulceration or impending ulceration predispose patients to an increased risk of post-operative infection. The present study was conducted to assess the efficacy of negative pressure wound therapy (NPWT) in preventing wound complications associated with surgical treatment of STSs with ulceration or impending ulceration, in patients treated between February 2012 and January 2013. A total of 5 patients, with a mean age of 48 years (range, 24-68 years), were enrolled in the present study. The diagnoses consisted of undifferentiated pleomorphic sarcoma (n=2), leiomyosarcoma (n=1), synovial sarcoma (n=1) and epithelioid sarcoma (n=1). According to American Joint Committee on Cancer criteria, 3 cases were stage III tumors, and the remaining 2 cases were of stages ⅡA and ⅡB, respectively. A total of 3 patients exhibited ulceration at diagnosis, and the remaining patients demonstrated impending ulceration. The mean wound area following wide resection of the tumor was 73 cm 2 (range, 45-110 cm 2 ). A continuous suction mode, with pressures measuring -200 to -300 mmHg, was used for 7-10 days on the soft-tissue defects as preparation for wound closure. Soft-tissue reconstruction included muscle flaps (n=2) and skin grafts (n=5). No major wound complications occurred. Post-operative functional and cosmetic outcomes were acceptable. A single patient demonstrated local recurrence 12 months after surgery and re-excision of the tumor was performed. All patients remained alive at the conclusion of follow-up, with a mean follow-up time of 26 months (range, 12-36 months). The present study demonstrated that NPWT is effective and safe when used as an adjunct to wound closure following resection of extremity STS with ulceration/impending ulceration.

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Section: Discussionmentioning

confidence: 99%

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

Chen

et al. 2016

Oncology Letters

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“…For wounds with oedema, these devices have the capacity to remove a large amount of fluid. 6 NPWT can be very useful for the management of enteroatmospheric fistula. 7 Continuous suction of the fistula output minimizes contact time between intestinal fluid and exposed peritoneum, thus effectively controlling intestinal spillage.…”

Section: Npwt Port Directly On the Fistulamentioning

confidence: 99%

Management of an open abdomen complicated by a high output entero-atmosferic fistula after a gastric by-pass

Salgado

2017

NPWTJ

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Abstract-: There is a wide spectrum of indications for negative pressure wound therapy (NPWT) including enterocutaneous fistulas, open abdomen management, abdominal wound dehiscence, open fractures, amputation wounds, sternal wound infections, vascular bypass site infection and many others. The article shows a case report of a patient with an enteroatmospheric fistula managed with NPWT. Control of intestinal contents from an entero-atmospheric fistula with the NPWT minimizes the damage to the healing bed of granulation tissue until the definitive closure of the fistula can be undertaken six to twelve months later.After a laparoscopic gastric bypass and 5 emergency interventions because of leaks at the jejunojenunal anastomosis and complications of the abdominal wall, an entero-atmospheric fistula appeared. This fistula was managed with the NPWT during two months. In the described case, the application of negative pressure dressing system allowed the management of the entero-atmospheric fistula until it became a stoma.

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“…The primary effect of NPWT in wound healing is complex (Table 1) [11]. Due to vacuum there is a macroscopic shrinkage of the wound (macrodeformation) [12].…”

Section: Mechanism Of Npwtmentioning

confidence: 99%

Negative Pressure Wound Therapy—An Effective, Minimally Invasive Therapeutic Modality in Burn Wound Management

Nagy¹,

Juhász²

2015

IJCM

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Effect of negative pressure wound therapy on wound healing

Cited by 395 publications

References 103 publications

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

Management of an open abdomen complicated by a high output entero-atmosferic fistula after a gastric by-pass

Negative Pressure Wound Therapy—An Effective, Minimally Invasive Therapeutic Modality in Burn Wound Management

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