Effect of negative air ions on computer operation, anxiety and salivary chromogranin A-like immunoreactivity

Nakane, Hideo; Asami, Osamu; Yamada, Yukio; Ohira, Hideki

doi:10.1016/s0167-8760(02)00067-3

Cited by 123 publications

(83 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chromogranin A is a soluble protein in adrenergic neurons. Although histochemical studies (26,27) revealed that the predominant source of salivary chromogranin A is salivary glands themselves, this protein directly reflects the sympathetic tone and sympathetic stress response (13,21,22,38). The results agree with previously obtained human data (34) and, at hormonal level, correspond to the results reported in pigs (37).…”

Section: Discussionsupporting

confidence: 90%

“…The effect was comparable in men and women, and therefore summarized results for all subjects are shown. State part of the STAI inventory (lower part alomo-pituitary-adrenal hormone cortisol and the sympathetic system marker, chromogranin-A (13,21,22,38), were used as objective measures of stress response. The standard Japanese version of the State Trait Anxiety Inventory (STAI, 36) served as a subjective measure of stress and anxiety perception.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

et al. 2007

View full text Add to dashboard Cite

Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

et al. 2007

View full text Add to dashboard Cite

show abstract

“…16 A recent finding from the author's laboratory further demonstrated that salivary CgA levels in the late-luteal phase significantly increased among women with severe premenstrual emotional symptoms, while salivary cortisol showed no menstrual-cyclic changes. 17 In contrast, stress-reduction interventions, such as aromatherapy with lavender essential oil, 14 exposure to negative air ions, 13 and laughter while watching a comedy video, 18 have decreased salivary CgA levels. Saliva testing is a novel device with the advantage of quick, painless, noninvasive, and relatively nonstressful sampling.…”

Section: Introductionmentioning

confidence: 99%

“…11 Salivary CgA, thus, has been proposed as a surrogate marker of sympathetic nervous system activity. 12 A series of studies has shown that compared with salivary cortisol, salivary CgA increases more rapidly and more sensitively to psychological stressors induced by activities such as public speaking, 12 word-processing and arithmetic tasks, 13,14 academic examinations, 15 and venipuncture in hospitalized children. 16 A recent finding from the author's laboratory further demonstrated that salivary CgA levels in the late-luteal phase significantly increased among women with severe premenstrual emotional symptoms, while salivary cortisol showed no menstrual-cyclic changes.…”

Section: Introductionmentioning

confidence: 99%

Effects of Olfactory Stimulation from the Fragrance of the Japanese Citrus Fruit Yuzu (Citrus junos Sieb. ex Tanaka) on Mood States and Salivary Chromogranin A as an Endocrinologic Stress Marker

Matsumoto

Asakura²,

Hayashi

2014

The Journal of Alternative and Complementary Medicine

View full text Add to dashboard Cite

Objective: This study investigated the soothing effects of fragrance from yuzu, a Japanese citrus fruit (Citrus junos Sieb. ex Tanaka), with salivary chromogranin A (CgA) used as an endocrinologic stress marker reflecting sympathetic nervous system activity. Methods: Twenty healthy women (mean age, 20.5 -0.1 years) participated in a randomized, controlled, crossover study. Participants were examined on two separate occasions-once using the yuzu scent and once using unscented water as a control-in the follicular phase. This experiment measured salivary CgA and the Profile of Mood States (POMS) as a psychological index before and after the aromatic stimulation. Results: Ten-minute inhalation of the yuzu scent significantly decreased salivary CgA. At 30 minutes after the inhalation period, the salivary CgA level further decreased. In addition, POMS revealed that inhalation of the aromatic yuzu oil significantly decreased total mood disturbance, a global measure of affective state, as well as four subscores of emotional symptoms (tension-anxiety, depression-dejection, anger-hostility, and confusion), as long as 30 minutes after the olfactory stimulation. Conclusions: Yuzu's aromatic effects may alleviate negative emotional stress, which, at least in part, would contribute to the suppression of sympathetic nervous system activity.

show abstract

“…Catecholamine levels are also commonly used as a sensitive biochemical index of stress; however, it is difficult to measure their concentrations in the saliva due to generally low levels and rapid degradation. Therefore, salivary chromogranin A (CgA) is used as a substitute marker for catecholamines, as it reflects psychological stress more quickly and sensitively than cortisol [2,3]. In addition, the use of saliva rather than blood has obvious advantages in terms of sample collection, such as speed, ease, subject mobility, and non-invasiveness.…”

Section: Introductionmentioning

confidence: 99%

Levels of awakening salivary CgA in response to stress in healthy subjects

Den

Toda

Ohira

et al. 2010

Environ Health Prev Med

View full text Add to dashboard Cite

Objects To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests. Methods The study cohort comprised 40 healthy male university students (age range 19-22 years). Salivary CgA levels were measured at 7:00 a.m. (awakening) and at 7:30, 8:00, and 8:30 a.m. (after awakening). Results The salivary CgA level was 0.91 ± 0.20 and 0.42 ± 0.1 pmol/ml at 7:00 a.m. in students scoring low (n = 26) and high (n = 14), respectively, on the ''severe depression'' subscale. This difference in salivary CgA levels at 7:00 between high and low scorers was statistically significant (p \ 0.05). Conclusions Our findings indicate that depression may influence secretions of salivary CgA via chronic stressrelated attenuation of the sympathetic-adrenomedullary system activity.

show abstract

Effect of negative air ions on computer operation, anxiety and salivary chromogranin A-like immunoreactivity

Cited by 123 publications

References 16 publications

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

Effects of Olfactory Stimulation from the Fragrance of the Japanese Citrus Fruit Yuzu (Citrus junos Sieb. ex Tanaka) on Mood States and Salivary Chromogranin A as an Endocrinologic Stress Marker

Levels of awakening salivary CgA in response to stress in healthy subjects

Contact Info

Product

Resources

About