Effect of nebivolol on blood oxygen transport indices and endothelial dysfunction in patients with arterial hypertension

Pronko, T. P.; Зинчук, В. В.

doi:10.1111/j.1475-097x.2008.00852.x

Cited by 10 publications

(17 citation statements)

References 35 publications

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“…Nitric oxide (NO) -dependent vascular relaxation seems to have a pivotal core role of the insulin-resistant state [25][26]. Various compounds of hemoglobin with NO were previously shown to be positively associated with hemoglobinoxygen affinity of the whole blood, leading to endothelial dysfunction, though the L-arginine-NO pathway [5,19,25,27]. Thirdly, higher serum EPO concentrations may suggest underlying adipose tissue hypoxemia in MS [21,28].…”

Section: Discussionmentioning

confidence: 99%

“…In the cross-sectional study, we derived patient data from 45,451 Chinese people (27,704 males and 17,747 females) who attended a routine clinical health examination at the First Affiliated Hospital of Wenzhou Medical University between January 2007 and December 2009. Only subjects with no data of components of MS or hemoglobin were excluded.…”

Section: Study Populationmentioning

confidence: 99%

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Is an elevated hemoglobin concentration a novel risk factor for metabolic syndrome in the Chinese population? a large-scale study

Zhou¹,

Wu²,

Wang³

et al. 2016

Oncotarget

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Objectives: The potential role of elevated hemoglobin concentration in the development of metabolic syndrome (MS) has not been adequately evaluated. We aim to determine the role of elevated hemoglobin concentrations as a risk factor in MS during health examination of Chinese individuals.Methods: 57,510 health check-up (45,451 by cross-sectional study and 12,059 in a longitudinal population) were conducted. Subjects were divided into quartiles for analyses, using multiple logistic analyses. Furthermore, the logistic analyses were used to explore the association between hemoglobin concentration and individual MS components respectively in the cross-sectional study and the longitudinal study.Results: In this cross-sectional study, 10.4% of 45,451 of the health checkup subjects developed MS. Multiple logistic analysis revealed that higher hemoglobin quartiles were positively associated with the development of MS which was in contrast to the lowest hemoglobin quartiles in the fully adjusted model (OR: 2.171, 95% CI 1.944 -2.424 in males, P < 0.001; 2.694, 95% CI 2.056 -3.531 in females, P < 0.001). In addition, during a five-year period, 10.8% of 12,059 health checkup subjects in a longitudinal study were identified. When adjustments were made for compounding factors, the HR for this association between MS and hemoglobin persisted (HR: 2.157, 95% CI 1.635 -2.847, P < 0.001).Conclusions: Serum hemoglobin levels were associated with the prevalence of MS in Chinese individuals, suggesting that serum hemoglobin levels might be a novel predictor for the incidence of MS.

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Section: Discussionmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Is an elevated hemoglobin concentration a novel risk factor for metabolic syndrome in the Chinese population? a large-scale study

Zhou¹,

Wu²,

Wang³

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…The confirmation of this research is found in another investigation, which revealed that antihypertensive treatment with nebivolol that stimulates nitric oxide production, improves endothelium-dependent dilatation and finally improves blood oxygen transport in hypertensive patients. 16 Additionally, mitochondrial function in arterial hypertension is impaired, which contributes to lower oxygen consumption and induces oxidative stress, 17 which also could be the reason for lower peak oxygen uptake in the arterial hypertension population.…”

Section: Physiological Models Of Maximal Oxygen Consumption Limitationsmentioning

confidence: 99%

Why is functional capacity decreased in hypertensive patients? From mechanisms to clinical studies

Tadić

Ivanović²

2014

Journal of Cardiovascular Medicine

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The influence of arterial hypertension on functional capacity is poorly understood. Studies have shown that peak oxygen consumption has been reduced in hypertensive patients, but the mechanisms are unclear. Left ventricular systolic and diastolic dysfunction, as well as left ventricular hypertrophy, are associated with lower functional capacity in patients with arterial hypertension. Furthermore, some investigations found a significant relationship between right ventricular systolic function and functional capacity in the general population. The aim of this review was to summarize current knowledge about the mechanisms of reduced functional capacity in hypertensive patients, including the impact of systemic and pulmonary circulations, as well as the influence of the left and right ventricle on oxygen consumption. Additionally, we reviewed all clinical studies regarding functional capacity in the population with arterial hypertension.

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“…Тому для зменшення симптомів АГ насамперед слід усунути прояви окис ного стресу. Деякі β-блокатори (невібо лол і карведілол) мають здатність збільшувати продукцію NO і покращувати ендотелійзалежне розслаблення, а також зменшувати прояви окисного стресу у пацієнтів з АГ, що може бути основою гіпотензивного ефекту цих препаратів [6,7].…”

Section: вступunclassified

Garlic Lowers Blood Pressure and Reduces Oxidative Stress by Increasing Plasma H2s Content in Patients With Arterial Hypertension

Kravchuk¹,

Goshovska²,

Korkach³

et al. 2020

Fiziol Zh

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Arterial hypertension (AH) is a multifactorial disease that is accompanied by the development of oxidative-nitrosative stress and insufficient production of hydrogen sulfide (H2S). We hypothesized that garlic bio supplement Full Spectrum Garlic (Swanson Health Product, USA) may be used as a potential H2S donor in treatment of AH in patients. The aim was to study the effect of garlic on blood pressure, ROS generation and cNOS/iNOS activity, biochemical in male 28-39 years old patients with grade II AH. It was found that 10 days of standard antihypertensive therapy (adrenoblockers, ACE inhibitors) with 30 days of garlic supplementation reduced mean systolic and diastolic pressures by 9 and 8 mm Hg respectively. Positive effects of garlic consumption on hemodynamic parameters were observed: enddiastolic volume increased by 8% and peripheral vascular resistance decreased by 11,3% . In the blood plasma of patients, H2S levels increased by 43,6% , the production of ROS and the content of lipid peroxidation products decreased significantly. It is important that the cNOS activity was increased by 130% and iNOS activity decreased by 38,3%. No significant changes in cholesterol, urea, creatinine, glucose, as well as erythrocyte parameters were observed, which indicates the tolerance of the garlic supplements. Thus, the hypotonic effect of garlic is realized by increasing endogenous H2S in plasma, improving endothelium-dependent relaxation of blood vessels and reducing the manifestations of oxidative stress, which makes it promising to use it in the complex therapy of hypertension.

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Effect of nebivolol on blood oxygen transport indices and endothelial dysfunction in patients with arterial hypertension

Cited by 10 publications

References 35 publications

Is an elevated hemoglobin concentration a novel risk factor for metabolic syndrome in the Chinese population? a large-scale study

Is an elevated hemoglobin concentration a novel risk factor for metabolic syndrome in the Chinese population? a large-scale study

Why is functional capacity decreased in hypertensive patients? From mechanisms to clinical studies

Garlic Lowers Blood Pressure and Reduces Oxidative Stress by Increasing Plasma H2s Content in Patients With Arterial Hypertension

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