Effect of natural polysaccharides and oligosaccharides on the permeability of cell membranes

Glycyrrhizic acid as a multifunctional drug carrier – From physicochemical properties to biomedical applications: A modern insight on the ancient drug

“…Despite the cellular structures are not all the same, influence factors and the through ways of drugs are similar in different cells. A number of results indicates that GA may enhance the drug penetration into the cells by influencing the cell membrane properties (Selyutina et al, 2016a;Selyutina et al, 2016b;Selyutina et al, 2014;Selyutina et al, 2017;Selyutina et al 2015, Meteleva et al, 2019. In particular, it was shown that GA could enhance the permeability of erythrocytes and K562 cells for formate ions (Selyutina et al, 2016b;Selyutina et al, 2014;Selyutina et al, 2017).…”

“…These complexes show significant advantages over other known DDS. In addition, it was de-change membrane properties (Selyutina et al, 2016a;Selyutina et al, 2016b;Selyutina et al, 2014;Selyutina et al, 2017;Selyutina et al 2015). Cell membrane forms the boundary between extracellular environment and intracellular space, provides cell integrity and implements barrier functions.…”

Supramolecular Carotenoid Complexes of Enhanced Solubility and Stability—The Way of Bioavailability Improvement

“…Molecules of oligosaccharides and polysaccharides such as cyclodextrins (CD), glycyrrhizic acid (glycyrrhizin, GA) and arabinogalactan (AG) are capable of forming “host-guest” complexes with bioactive compounds substantially enhancing solubility and bioavailability [21]. Additional advantages like improvements in chemical stability, protection of bioactive compounds from external environment, taste modification and controlled release make them interesting delivery systems for further study to incorporate bioactive compounds into beverages or foods fortified with bioactive compounds, or in pharmaceuticals or cosmetics.…”

“…In particular, it was found that glycyrrhizin is able to form water-soluble supramolecular complexes with a variety of lipophilic drugs [35,41,42,43,44,45,46,47,48,49,50,51,52,53] These complexes show significant advantages over other known drug delivery systems, possessing increased solubility, stability and bioavailability. In addition, the membrane modifying ability of GA has been described [21,54,55,56,57]. We consider that the key factor in its therapeutic activity is its ability to incorporate into the lipid bilayer and to increase the membrane fluidity and permeability [35].…”

“…Recent studies have shown that GA is able not only to form inclusion complexes with carotenoids and various drug molecules, but also to modify the structure of lipid membranes [21,34,54,55,56,57]. Using NMR relaxation techniques and molecular dynamics simulation (MD) it was demonstrated that GA molecules are able to penetrate into lipid bilayer and affect the lipid dynamics.…”