Effect of Natural and Artificial Dentin Conditioners on the Release of Vascular Endothelial Growth Factor

Effect of Different Root Canal Irrigant Solutions on the Release of Dentin-Growth Factors: A Systematic Review and Meta-Analysis

“…Of these, 15 were excluded for not investigating or comparing endodontic irrigants, and seven studies did not include dentin. Sixteen studies that met the criteria were included in the qualitative synthesis [ 10 , 13 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ], and eight were included in the quantitative synthesis [ 10 , 13 , 22 , 24 , 29 , 32 , 33 , 35 ].…”

“…The main characteristics of the included studies are shown in Table 1 . Most studies have employed dentin slices as the test system [ 10 , 22 , 23 , 26 , 27 , 28 , 29 , 31 , 32 , 35 ]. Five studies used root canal segments [ 13 , 23 , 24 , 25 , 33 ], and two studies used solubilized dentin powder [ 30 , 34 ].…”

“…Sadaghiani et al [ 32 ] showed a greater release of VEGF by calcium hydroxide in the immunogold assay, while 10% citric acid was more effective as detected by the ELISA method. Khan et al [ 23 ] showed better results for VEGF release by 9% etidronic acid in dentin cylinders when compared to 17% EDTA and 1% phytic acid.…”

“…On the other hand, most studies fully met the test system domain, specifying the parameters used in the management of test substances, for both reporting quality [ 23 , 24 , 25 , 26 , 29 , 30 , 31 , 32 , 33 , 35 ] and methodological quality [ 10 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ], and also the domain related to the doses used and the number of replicates performed, named the administration of test compound, for reporting quality [ 10 , 22 , 23 , 25 , 26 , 28 , 29 , 30 , 33 , 34 ] and methodological quality [ 10 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 , 34 ]. Furthermore, all studies were classified as directly relevant and with an overall low risk.…”

“…Eight studies were not included in the meta-analyses because they used quite different assessment techniques or did not report sufficient quantitative data to be compared [ 23 , 25 , 26 , 27 , 28 , 30 , 31 , 34 ]. Atesci et al [ 27 ] were not included since the methodology assessed the total growth factor in dentin and not the level of growth factor released.…”