Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

Mrizak, Dhafer; Martin, Nathalie; Barjon, Clément; Jimenez-Pailhes, Anne-Sophie; Mustapha, Rami; Niki, Toshiro; Guigay, J.; Pancré, Véronique; Launoit, Yvan de; Busson, P.; Moralès, Olivier; Delhem, Nadira

doi:10.1093/jnci/dju363

Cited by 173 publications

(176 citation statements)

References 33 publications

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“…Current findings suggest that exosome-derived LMP-1 plays central roles in attenuating the immune response in both EBV infection and the development and progression of EBV cancers [20,22,23]. For instances, the LMP1-and galectin 9-containing exosomes derived from EBV-infected LCLs and NPC cells have been found to inhibit infiltrating T-lymphocyte activation and proliferation through an action mediated by the conserved trans-membrane domain of LMP1 [20].…”

Section: Exosomal Latent Membrane Proteins (Lmps)mentioning

confidence: 94%

“…Mrizak and co-workers demonstrated that CCL20-containing exosomes recruited the CD25+FOXP3+ Treg cells and enhanced their expansion in NPC [22]. The involvement of these exosomes in the Treg interaction may therefore support immune evasion in NPC.…”

Section: Other Exosomal Pathogenic Factorsmentioning

confidence: 97%

“…[20], EGFR [30], HIF1α [19], ICAM1 [21], FGF2 [25], chemokine (C-C motif) ligand 20 (CCL20) [22], dUTPase [48] and interleukins (ILs)/caspase 1/interferon-inducible protein 16 (IFI16) [49] ( Table 1).…”

Section: Other Exosomal Pathogenic Factorsmentioning

confidence: 99%

“…As abovementioned, exosomes also contribute to the immune evasion of cancer cells [20,22,23]. For example, the galectin-9-containing exosomes have been shown to inhibit the proliferation and induce apoptosis of EBV-specific T cell, hence preventing the T cell-mediated recognition and killing of these cancer cells [20,23].…”

Section: Exosomes As Predictive Markers For Therapy Responsementioning

confidence: 99%

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Exosomes as the Promising Biomarker for Epstein-Barr Virus (EBV)-Associated Cancers

Teow¹,

Peh²

2017

Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases

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Exosomes are microvesicles with sizes ranging from 50 to 150 nm. These small vesicles are known to morphologically and functionally resemble virus particles from human immunodeficiency virus type I (HIV-I) and human T-lymphotropic virus type I (HTLV-I). The function of exosomes is to mainly mediate cell-to-cell communication by exchanging various macromolecules including proteins, lipids and nucleic acids in diverse cellular processes. Due to its size and structural simplicity, the transfer of pathogenic or virulent cellular factors across the cells mediated by exosomes is more efficient, hence facilitating the dissemination of viral infections and cancer diseases. The pathogenic role of exosomes in various cancers such as lung and breast, and their potentials as biomarkers have been previously studied, yet limited information is known for Epstein-Barr virus (EBV)-associated cancers. In this chapter, we discuss current evidences that support the pathogenic roles of exosomes in EBV-related cancers and their potentials as biomarkers in cancer diagnostics and therapy response. Here, we also highlight the potential challenges in the development of exosome-based biomarkers for clinical application.

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Section: Exosomal Latent Membrane Proteins (Lmps)mentioning

confidence: 94%

Section: Other Exosomal Pathogenic Factorsmentioning

confidence: 97%

Section: Other Exosomal Pathogenic Factorsmentioning

confidence: 99%

Section: Exosomes As Predictive Markers For Therapy Responsementioning

confidence: 99%

See 2 more Smart Citations

Exosomes as the Promising Biomarker for Epstein-Barr Virus (EBV)-Associated Cancers

Teow¹,

Peh²

2017

Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases

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“…Previous literatures have shown that the appearance of malignant process producing several immunogenic viral proteins within a context of local inflammation and heavy leukocytic infiltration is one major paradox of NPC pathogenesis. Additionally, the different TIL subsets have strong prognostic value for NPC patients 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Bile acids cycle disruption in patients with nasopharyngeal carcinoma promotes the elevation of interleukin-10 secretion

Wang¹,

Liu

Jin

et al. 2016

Afr H. Sci.

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Mechanisms of Epstein‐Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma

Wang

Lü

et al. 2020

Cancer Medicine

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Epstein-Barr virus (EBV) is an oncogenic virus that is closely associated with development of several malignancies, including Hodgkin lymphoma (HL), Burkitt lymphoma, nasopharyngeal carcinoma (NPC), and EBV+ gastric carcinoma (GC). EBV-DNA can be detected in approximately 90% of NPC tissues, where the virus express a limited subset of genes; these include EBV nuclear antigen 1 (EBNA1), latent membrane protein 1 (LMP1), and LMP2. Although massive EBV-specific cytotoxic T cells (CTLs) can be detected in NPC, they are unable to eliminate EBV-infected cells in vivo. 1,2 Furthermore, our previous study found high-density infiltration of CD8+ T cells in NPC tissues have lower overall survival (OS) and progression-free survival. 3 We speculated that is related immune evasion in tumor. Several immune evasion mechanisms have been proposed, one current focus in attempt to understand this phenomenon is regulatory T cells (Tregs).

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Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

Abstract: Interactions between NPC-Exo and Treg represent a newly defined mechanism that may be involved in regulating peripheral tolerance by tumors and in supporting immune evasion in human NPC.

Cited by 173 publications

References 33 publications

Exosomes as the Promising Biomarker for Epstein-Barr Virus (EBV)-Associated Cancers

Exosomes as the Promising Biomarker for Epstein-Barr Virus (EBV)-Associated Cancers

Bile acids cycle disruption in patients with nasopharyngeal carcinoma promotes the elevation of interleukin-10 secretion

Mechanisms of Epstein‐Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma

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