Effect of narrowband ultraviolet B therapy on inflammatory markers and body fat composition in moderate to severe psoriasis

Romaní, Jorge; Caixàs, Assumpta; Carrascosa, J.M.; Ribera, Miquel; Rigla, Mercedes; Luelmo, Jesús

doi:10.1111/j.1365-2133.2012.10883.x

Cited by 51 publications

(79 citation statements)

References 39 publications

(65 reference statements)

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“…10 Our results are also supported by the data from Romaní et al, who observed increased systemic levels of LDL cholesterol, non-HDL (high-density lipoprotein) cholesterol and Apo-B in psoriasis patients, levels which were unaffected by phototherapy. 41 Signs of a persistent inflammatory process after UV therapy were also established by Coimbra et al 42 In contrast, UV therapy led to a decrease in IL-22, IL-17, IL-23, IL-8 TNF-α, and VEGF serum levels, 43 suggesting that the skin is the major source of these cytokines in psoriasis. However, the literature is controversial and both we and others have shown a lack of effect by UV therapy on the studied cytokines.…”

Section: T Cells and Langerhans Cells Of The Inflammatory Infiltratementioning

confidence: 93%

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

Sigurdardottir

Ekman

Ståhle

et al. 2014

Journal of the American Academy of Dermatology

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Section: T Cells and Langerhans Cells Of The Inflammatory Infiltratementioning

confidence: 93%

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

Sigurdardottir

Ekman

Ståhle

et al. 2014

Journal of the American Academy of Dermatology

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“…Recent studies suggest that vitamin D insufficiency is also common in patients with psoriasis (8)(9)(10). Gisondi et al (8) found that, in Italy in winter, serum 25(OH)D was below 50 nmol/l in 81% of patients with psoriasis compared with 30% of healthy controls.…”

Section: Vitamin D Insufficiency Is Common In Europe and Northmentioning

confidence: 97%

Narrow-band Ultraviolet B Treatment Boosts Serum 25-hydroxyvitamin D in Patients with Psoriasis on Oral Vitamin D Supplementation

Ala‐Houhala

Karppinen²,

Vähävihu³

et al. 2014

Acta Derm Venerol

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A course of treatment with narrow-band ultraviolet B (NB-UVB) improves psoriasis and increases serum 25-hydroxyvitamin D (25(OH)D). In this study 12 patients with psoriasis who were supplemented with oral cholecalciferol, 20 µg daily, were given a course of NB-UVB and their response measured. At baseline, serum 25(OH)D was 74.14 ± 22.9 nmol/l. At the 9th exposure to NB-UVB 25(OH)D had increased by 13.2 nmol/l (95% confidence interval (95% CI) 7.2-18.4) and at the 18th exposure by 49.4 nmol/l (95% CI 35.9-64.6) above baseline. Psoriasis Area Severity Index score improved from 8.7 ± 3.5 to 4.5 ± 2.0 (p < 0.001). At baseline, psoriasis lesions showed low vitamin D metabolizing enzyme (CYP27A1, CYP27B1) and high human β-defensin-2 mRNA expression levels compared with those of the healthy subjects. In conclusion, NB-UVB treatment significantly increases serum 25(OH)D in patients with psoriasis who are taking oral vitamin D supplementation, and the concentrations remain far from the toxicity level. Healing psoriasis lesions show similar mRNA expression of vitamin D metabolizing enzymes, but higher antimicrobial peptide levels than NB-UVB-treated skin in healthy subjects.

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“…After the studies made in 1990s where high levels of homocysteine were found in plasma samples of subjects who had or would likely to have a history of myocardial infarction, ischemic stroke or peripheral vascular disease and the association of homocysteine with atherosclerosis and hypercoagulability had been shown [6][7][8][9][10][11][12] , along with increased attention to the comorbidities of psoriasis, as far as we know, 19 studies have been conducted to explore homocysteine levels in these patients. Homocysteine level was found to be high in 12 and normal in 7 of these studies [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] . Since this sulfur-containing amino acid is not taken through diet and not producing protein, homocysteine is formed via methionine catabolism 8,11,27 .…”

Section: Introductionmentioning

confidence: 99%

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

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ÖzBackground and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age-and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population Keywords: Psoriasis, homocysteine, folic acid Amaç: Homosistein kardiyovasküler hastalık, otoimmünite-enflamasyon ve DNA metilasyonu ile ilişkilendirilen sülfür içeren bir aminoasittir. Bu olgu-kontrol çalışmasında psoriazisli hastalarda plazma homosistein düzeylerinin ve homosisteini etkileyen folik asit, vitamin B6 ve vitamin B12 düzeylerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Polikliniğimizde takip edilen erişkin plak tip psoriazis hastaları ile yaş ve cinsiyet uyumlu kontrol grubunda alkol, kahve ve sigara tüketimi sorgulandı, katılımcıların boy ve ağırlıkları ölçüldü. Hastaların Psoriazis Alan Şiddet İndeksleri (PAŞİ) hesaplandı. Sabah açlık kan örnekleri alınarak homosistein, folik asit, vitamin B12, vitamin B6, kan şekeri, serum total kolesterol, trigliserid, yüksek yoğunluklu lipoproteinler (HDL), eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) değerleri çalışıldı. Bulgular: Psoriazisli hasta (n=43) ve kontrol grubu (n=47) arasında vücut kitle inde...

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Effect of narrowband ultraviolet B therapy on inflammatory markers and body fat composition in moderate to severe psoriasis

Abstract: We characterized inflammatory and atherogenic profiles of Spanish patients with psoriasis compared with matched controls. After NB-UVB therapy we demonstrated improvement in psoriasis and some systemic inflammation markers, which were not mediated by enhancement of vitamin D synthesis.

Cited by 51 publications

References 39 publications

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

Narrow-band Ultraviolet B Treatment Boosts Serum 25-hydroxyvitamin D in Patients with Psoriasis on Oral Vitamin D Supplementation

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

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