Effect of Naringin on myocardial potency of Resveratrol against ischemia reperfusion induced myocardial toxicity in rat

Chakraborty, Manodeep; Bhattacharjee, Ananya; Ahmed, Mohammed Gulzar; Sindhu, S; Shahin, Haleema; Taj, Tahreen

doi:10.1016/j.synres.2020.100062

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…UV detection was carried out at 306 nm and 342 nm with 30 min run time at column temperature 25°C. 21…”

Section: Impact Of Piperine On the Pharmacokinetics Of Resveratrolmentioning

confidence: 99%

Cardioprotective Potential of Resveratrol Alone and in Combination with Piperine on Isoproterenol-induced Myocardial Infarction in Rat: Investigation on Oral Bioavailability of Resveratrol

Salian,

Noushida,

Jaswanth Gowda

et al. 2023

Int J. Pharm. Investigation

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Background: Resveratrol (3,4,5-trihydroxystilbene), a polyphenol derived from plant sources, despite its cardioprotective properties, has limited therapeutic impact due to its low in vivo bioavailability and rapid metabolism, which are major barriers to its effectiveness. Piperine, a nitrogenous substance, has well-established bioenhancer activity and cardioprotective potential. The objective of the study was to investigate the cardioprotective potential of resveratrol and piperine on isoproterenol-induced myocardial infarction in rats, both alone and in combination and to assess the oral bioavailability of resveratrol when co-administered with piperine. Materials and Methods: Resveratrol, piperine, and their combinations (20 mg/kg, oral) were administered to rats as pre-treatments for 28 days. Myocardial infarction was induced by giving isoproterenol (85 mg/kg) subcutaneously. Pharmacokinetic parameters were analyzed by UFLC using rat plasma. The chromatographic separation was achieved on Eclipse plus C 18 Column (25 cm x 5 cm x 4.6µ) with L1 packing using mobile phase containing mixer of milli Q water and methanol (30:70% v/v) at a flow rate of 1 mL/min. Results: The treatment group exhibited a considerable (p<0.001) improvement in heart rate, biomarker, antioxidant, and histological changes compared to the isoproterenol group, confirming the effectiveness of resveratrol. A significant improvement in pharmacokinetic parameters of resveratrol was observed in plasma samples of animals treated with a combination, as compared to those treated with resveratrol alone. Conclusion: The combination of resveratrol and piperine significantly reduced the risk of myocardial infarction induced by isoproterenol when compared to the group that received resveratrol alone. This effect can be attributed to the cardioprotective potential of resveratrol and piperine, as well as piperine's ability to enhance the oral bioavailability of resveratrol.

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“…UV detection was carried out at 306 nm and 342 nm with 30 min run time at column temperature 25°C. 21…”

Section: Impact Of Piperine On the Pharmacokinetics Of Resveratrolmentioning

confidence: 99%

Cardioprotective Potential of Resveratrol Alone and in Combination with Piperine on Isoproterenol-induced Myocardial Infarction in Rat: Investigation on Oral Bioavailability of Resveratrol

Salian,

Noushida,

Jaswanth Gowda

et al. 2023

Int J. Pharm. Investigation

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“…They claimed a notable enhancement in bioavailability, C max with a significant reduction in the clearance rate of the drug combined with naringin. 46…”

Section: Naringinmentioning

confidence: 99%

Herbal Bioenhancers with Nanocarriers: A Promising Approach for Oral Peptide Delivery

Raghunath

Koland

Vadakkepushpakath

et al. 2022

Int J. Pharm. Investigation

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The oral delivery of protein and peptide drugs faces immense challenges due to the harsh gastrointestinal (GI) environment, large molecular size, and low stability. Even though different approaches are employed to deliver peptide drugs efficiently, they have limited success. Recently, the use of nanoparticles as carriers for peptides as a means of surmounting the gastrointestinal barrier and as an effective alternative to parenteral administration has gained much attention. It is often necessary to supplement this mode of delivery by using strategies such as permeation enhancers. Bio-enhancers play a significant role in reducing the dose, drug resistance, toxicity, and treatment expenses. The potential of herbal bio-enhancers as a safe and effective substitute to non-herbal permeation enhancers in improving oral absorption of peptides from nanoparticulate systems has been explored recently. Piperine is counted first in the list of bio-enhancers and can improve the bioavailability of peptides and other drugs. Other molecules like naringin, glycyrrhizin, quercetin have great significance either alone or in combination in improving the oral bioavailability of drug molecules. Bioenhancers are beneficial for drugs with poor lipid solubility and large molecular size, causing poor absorption and low bioavailability. Herbal bioenhancers can decrease the dose, drug resistance, toxicity, adverse effects, and overall treatment cost as they are inert, easily procured and economical. This review article focuses on the significance of nanoparticles in the oral delivery of peptide drugs and the vital role played by herbal bioenhancers in their absorption from the GI tract.

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Synergistic Welfare of Synbiotic Nutraceuticals on Chronic Respiratory Diseases

Chanda,

Bonde,

Tiwari

et al. 2024

Synbiotics in Human Health: Biology to Drug Delivery

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Effect of Naringin on myocardial potency of Resveratrol against ischemia reperfusion induced myocardial toxicity in rat

Cited by 4 publications

References 18 publications

Cardioprotective Potential of Resveratrol Alone and in Combination with Piperine on Isoproterenol-induced Myocardial Infarction in Rat: Investigation on Oral Bioavailability of Resveratrol

Cardioprotective Potential of Resveratrol Alone and in Combination with Piperine on Isoproterenol-induced Myocardial Infarction in Rat: Investigation on Oral Bioavailability of Resveratrol

Herbal Bioenhancers with Nanocarriers: A Promising Approach for Oral Peptide Delivery

Synergistic Welfare of Synbiotic Nutraceuticals on Chronic Respiratory Diseases

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