Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials

Wu, Wei‐Te; Liao, Hui-Yi; Chung, Yu-Chieh; Li, Wan-Fen; Tsou, Tsui‐Chun; Li, Lih-Ann; Lin, Ming-Hsiu; Ho, Ja‐an Annie; Wu, Trong-Neng; Liou, Saou-Hsing

doi:10.3390/ijms15010878

Cited by 45 publications

(42 citation statements)

References 58 publications

(76 reference statements)

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“…These included six published peer-reviewed articles (Table 1) (Lee et al 2012, 2015; Liou et al 2012; Liao et al 2014a, b; Wu et al 2014) and nine unpublished articles (Table 2), comprising one conference paper (Pelclova et al 2012), one doctoral dissertation (Cui 2013), and seven conference abstracts (Ichihara et al 2013; Fatkhutdinova et al 2013; Pelclova et al 2013, 2014a, b; Vermeulen et al 2014; Liou et al 2013). In addition to the study reports published in journals and conference proceedings, we found three ongoing epidemiologic studies being conducted in the United States, France, and Australia (Schubauer-Berigan et al 2013; Guseva Canu et al 2013; Glass et al 2013), but their findings have not been reported.…”

Section: Resultsmentioning

confidence: 99%

“…Nine different populations were evaluated in 15 studies; among them, the two most commonly studied were Taiwan populations (Liou et al 2012; Liao et al 2014a, b; Wu et al 2014; Liou et al 2013) and Czech Republic populations (Pelclova et al 2012, 2014a, b). Of the 15 studies identified, 11 used a cross-sectional study design (Liou et al 2012, 2014a, b; Wu et al 2014; Lee et al 2015; Cui 2013; Ichihara et al 2013; Fatkhutdinova et al 2013; Pelclova et al 2012, 2013, 2014a; Vermeulen et al 2014), and 4 used a longitudinal study design with repeated measurements (panel study) (Liao et al 2014b; Cui 2013; Liou et al 2013; Pelclova et al 2014b).…”

Section: Resultsmentioning

confidence: 99%

“…Of the 15 studies identified, 11 used a cross-sectional study design (Liou et al 2012, 2014a, b; Wu et al 2014; Lee et al 2015; Cui 2013; Ichihara et al 2013; Fatkhutdinova et al 2013; Pelclova et al 2012, 2013, 2014a; Vermeulen et al 2014), and 4 used a longitudinal study design with repeated measurements (panel study) (Liao et al 2014b; Cui 2013; Liou et al 2013; Pelclova et al 2014b). One was a descriptive pilot study (Lee et al 2012), and another used both cross-sectional and longitudinal study designs (Cui 2013).…”

Section: Resultsmentioning

confidence: 99%

“…These included a pilot case study (Lee et al 2012), four cross-sectional studies (Liou et al 2012, 2014a; Wu et al 2014; Lee et al 2015), and one longitudinal study (Liao et al 2014b). Of the published studies, four involved a single group of workers in Taiwan and the other two involved workers in Korea.…”

Section: Published Studiesmentioning

confidence: 99%

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Assessing the first wave of epidemiological studies of nanomaterial workers

et al. 2015

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The results of early animal studies of engineered nanomaterials (ENMs) and air pollution epidemiology suggest that it is important to assess the health of ENM workers. Initial epidemiological studies of workers’ exposure to ENMs (<100 nm) are reviewed and characterized for their study designs, findings, and limitations. Of the 15 studies, 11 were cross-sectional, 4 were longitudinal (1 was both cross-sectional and longitudinal in design), and 1 was a descriptive pilot study. Generally, the studies used biologic markers as the dependent variables. All 11 cross-sectional studies showed a positive relationship between various biomarkers and ENM exposures. Three of the four longitudinal studies showed a negative relationship; the fourth showed positive findings after a 1-year follow-up. Each study considered exposure to ENMs as the independent variable. Exposure was assessed by mass concentration in 10 studies and by particle count in six studies. Six of them assessed both mass and particle concentrations. Some of the studies had limited exposure data because of inadequate exposure assessment. Generally, exposure levels were not very high in comparison to those in human inhalation chamber studies, but there were some exceptions. Most studies involved a small sample size, from 2 to 258 exposed workers. These studies represent the first wave of epidemiological studies of ENM workers. They are limited by small numbers of participants, inconsistent (and in some cases inadequate) exposure assessments, generally low exposures, and short intervals between exposure and effect. Still, these studies are a foundation for future work; they provide insight into where ENM workers are experiencing potentially adverse effects that might be related to ENM exposures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Published Studiesmentioning

confidence: 99%

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Assessing the first wave of epidemiological studies of nanomaterial workers

et al. 2015

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“…[36] also found insufficient evidence to link health outcomes with workplace exposure to ENMs. The review included five of the studies that are included in our review [17–19, 21, 23], but found an additional eight unpublished studies and one published study we did not identify [37]. The unpublished studies were, however, mainly the review authors’ own studies and would have been difficult to locate without prior knowledge, thus, these did not comply with the unbiased inclusion criteria implemented herein.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Screening and Surveillance Programs to Protect Workers from Nanomaterials

et al. 2016

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BackgroundScreening and surveillance approaches for workers exposed to nanomaterials could aid in early detection of health effects, provide data for epidemiological studies and inform action to decrease exposure. The aim of this review is to identify such screening and surveillance approaches, in order to extract available data regarding (i) the studies that have successfully been implemented in present day, (ii) identification of the most common and/or toxic nano-related health hazards for workers and (iii) possible exposure surveillance markers. This review contributes to the current understanding of the risk associated with nanomaterials by determining the knowledge gap and making recommendations based on current findings.MethodsA systematic review was conducted. PubMed and Embase were searched to identify articles reporting on any surveillance-related study that described both exposure to nanomaterials and the health indicators that were measured. Four reviewers worked in pairs to independently assess the eligibility of studies and risk of bias before extraction of data. Studies were categorised according to the type of study and the medical surveillance performed, which included the type of nanomaterial, any exposure details provided, as well as health indicators and biomarkers tested.ResultsInitially 92 studies were identified, from which 84 full texts were assessed for eligibility. Seven studies met all the inclusion criteria, i.e. those performed in Taiwan, Korea, Czech Republic and the US. Of these, six compared health indicators between exposed and unexposed workers and one study described a surveillance program. All studies were at a high risk of bias. Workers were exposed to a mix of nanomaterials in three studies, carbon-based nanomaterials in two studies, nano-silver in one study and nano-titanium oxide in the other study. Two studies did not find a difference in biomarkers between exposed and unexposed workers. In addition, differences in early effects on pulmonary function or neurobehavioral tests were not observed. One study found an increased prevalence of allergic dermatitis and “sneezing” in the exposed group.ConclusionsThis review of recently published data on surveillance studies proves that there is a gap in the current knowledge, where most of the surveillance-related studies reported do not follow a set format that provides the required information on ENM characterisation, the type of exposure and the measured indicators/biomarkers. Hence, there is very low quality evidence that screening and surveillance might detect adverse health effects associated with workplace exposure. This systematic review is relevant because it proves that, although surveillance programs have been initiated and preliminary results are being published, the current studies are actually not answering the important questions or solving the overall problem regarding what the potential health hazards are among workers either handling or potentially exposed to ENMs. The recommendations, thus proposed, are based on an ...

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Research advance of occupational exposure risks and toxic effects of semiconductor nanomaterials

Wu,

Ding,

Pang

et al. 2024

J of Applied Toxicology

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In recent years, semiconductor nanomaterials, as one of the most promising and applied classes of engineered nanomaterials, have been widely used in industries such as photovoltaics, electronic devices, and biomedicine. However, occupational exposure is unavoidable during the production, use, and disposal stages of products containing these materials, thus posing potential health risks to workers. The intricacies of the work environment present challenges in obtaining comprehensive data on such exposure. Consequently, there remains a significant gap in understanding the exposure risks and toxic effects associated with semiconductor nanomaterials. This paper provides an overview of the current classification and applications of typical semiconductor nanomaterials. It also delves into the existing state of occupational exposure, methodologies for exposure assessment, and prevailing occupational exposure limits. Furthermore, relevant epidemiological studies are examined. Subsequently, the review scrutinizes the toxicity of semiconductor nanomaterials concerning target organ toxicity, toxicity mechanisms, and influencing factors. The aim of this review is to lay the groundwork for enhancing the assessment of occupational exposure to semiconductor nanomaterials, optimizing occupational exposure limits, and promoting environmentally sustainable development practices in this domain.

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Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials

Cited by 45 publications

References 58 publications

Assessing the first wave of epidemiological studies of nanomaterial workers

Assessing the first wave of epidemiological studies of nanomaterial workers

Systematic Review of Screening and Surveillance Programs to Protect Workers from Nanomaterials

Research advance of occupational exposure risks and toxic effects of semiconductor nanomaterials

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