Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials

Hassanizadeh, Shirin; Shojaei, Mehrnaz; Bagherniya, Mohammad; Orekhov, Alexander N.; Sahebkar, Amirhossein

doi:10.1002/biof.1932

Cited by 23 publications

(5 citation statements)

References 115 publications

(264 reference statements)

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“…Similarly, in WikiPathway pathway analysis results, SARS-CoV-2 altering angiogenesis via NRP1 and Endochondral Ossification are involved in the progression of COVID-19 and OA, respectively. Furthermore, a study showed that curcumin, which has anti-inflammatory and antioxidant effects, can be used to treat a variety of diseases, including COVID-19 and OA, which also suggests that inflammation and oxidation may be the shared pathogenic mechanisms in COVID-19 and OA ( 25 ). More importantly, in one study, Lauwers et al.…”

Section: Discussionmentioning

confidence: 99%

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

et al. 2023

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BackgroundCorona Virus Disease 2019 (COVID-19) and Osteoarthritis (OA) are diseases that seriously affect the physical and mental health and life quality of patients, particularly elderly patients. However, the association between COVID-19 and osteoarthritis at the genetic level has not been investigated. This study is intended to analyze the pathogenesis shared by OA and COVID-19 and to identify drugs that could be used to treat SARS-CoV-2-infected OA patients.MethodsThe four datasets of OA and COVID-19 (GSE114007, GSE55235, GSE147507, and GSE17111) used for the analysis in this paper were obtained from the GEO database. Common genes of OA and COVID-19 were identified through Weighted Gene Co-Expression Network Analysis (WGCNA) and differential gene expression analysis. The least absolute shrinkage and selection operator (LASSO) algorithm was used to screen key genes, which were analyzed for expression patterns by single-cell analysis. Finally, drug prediction and molecular docking were carried out using the Drug Signatures Database (DSigDB) and AutoDockToolsResultsFirstly, WGCNA identified a total of 26 genes common between OA and COVID-19, and functional analysis of the common genes revealed the common pathological processes and molecular changes between OA and COVID-19 are mainly related to immune dysfunction. In addition, we screened 3 key genes, DDIT3, MAFF, and PNRC1, and uncovered that key genes are possibly involved in the pathogenesis of OA and COVID-19 through high expression in neutrophils. Finally, we established a regulatory network of common genes between OA and COVID-19, and the free energy of binding estimation was used to identify suitable medicines for the treatment of OA patients infected with SARS-CoV-2.ConclusionIn the present study, we succeeded in identifying 3 key genes, DDIT3, MAFF, and PNRC1, which are possibly involved in the development of both OA and COVID-19 and have high diagnostic value for OA and COVID-19. In addition, niclosamide, ciclopirox, and ticlopidine were found to be potentially useful for the treatment of OA patients infected with SARS-CoV-2.

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Section: Discussionmentioning

confidence: 99%

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

et al. 2023

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“…A secondary analysis of another trial investigating the use of eicosapentaenoic acid (i.e., omega 3 supplement) showed that individuals who presented increased blood levels of omega 3 during the trial had lower PTSD symptom severity [ 44 ]. For the treatment of anxiety disorders, several anti-inflammatory compounds have been suggested to be associated with symptom improvement, including vitamin D [ 45 ], nano-curcumin [ 46 ], Carotenoids [ 47 ] and hydrogen gas [ 48 ]. The use of glutamatergic modulators has also been reported to improve PTSD symptoms, especially those reexperiencing arousal [ 49 ], and anxiety disorders [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroinflammation in the prefrontal-amygdala-hippocampus network is associated with maladaptive avoidance behaviour

Antunes,

Gouveia,

Kuroki

et al. 2024

Heliyon

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“…Curcumin is derived from Curcuma longa and showed pharmacological activities such as anti-oxidation, anti-inflammation and anti-bacterial properties [ 74 ].…”

Section: Protections Of Nacs On Proteinuria and In Vivo ...mentioning

confidence: 99%

Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease

Gong,

Wang,

Wang

et al. 2023

Renal Failure

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Diabetic kidney disease (DKD) is a primary cause of end-stage renal disease. Proteinuria is a clinical indicator of the different stages of DKD, and podocyte injury is a major cause of proteinuria. Podocyte-specific proteins (PSPs) play important roles in the normal filtration of podocytes. Studies have shown that natural active compounds (NACs) can ameliorate proteinuria; however, the mechanism related to PSPs needs to be explored. In this study, the five stages of DKD related to proteinuria and the functions of PSPs are displayed separately. Mechanisms for ameliorating proteinuria and improving the PSPs of the 15 NACs are summarized. The in vitro and in vivo mechanistic research showed that five compounds, astragaloside IV, ligustrazine, berberine, emodin and resveratrol, exerted renal protective effects via AMPK signaling, icariin and berberine via TLR4 signaling, hirudin and baicalin via MAPK signaling, curcumin and baicalin via NF-κB signaling, and emodin via protein kinase RNA-like endoplasmic reticulum kinase signaling. The 13 PSPs were divided into five categories: actin cytoskeleton, basal domain, apical domain, slit diaphragm, and others. In conclusion, anti-inflammatory effects, anti-oxidative stress, and enhanced autophagy are the main mechanisms underlying the ameliorative effects of NACs. Podocyte apoptosis is mainly related to nephrin and podocin, which are the most studied slit diaphragm PSPs.

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Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials

Cited by 23 publications

References 115 publications

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

Neuroinflammation in the prefrontal-amygdala-hippocampus network is associated with maladaptive avoidance behaviour

Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease

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