Effect of nabilone on nausea and vomiting after total abdominal hysterectomy

Abstract

In a prospective, double-blind study, we have examined the effect of preoperative nabilone on postoperative nausea and vomiting (PONV). Sixty women, less than 70 yr old, undergoing total abdominal hysterectomy, were allocated randomly to receive either nabilone 2 mg or metoclopramide 10 mg orally 90 min before induction of anaesthesia. The study was designed to detect a 50% difference in the incidence of postoperative vomiting between the two groups, with an 80% power of achieving a statistically significant result at the 5% level. Data from 53 patients were analysed: the incidences of nausea and vomiting for the metoclopramide group were 70% and 67%, respectively; the corresponding values for the nabilone group were 73% and 54%. These differences were not significant.

Cannabinoids in anaesthesia and pain therapy

“…The antiemetic effect of the oral cannabinoid nabilone on nausea and vomiting was investigated in a single randomized study including 60 women undergoing total abdominal hysterectomy [6]. The study, which was published in 1994, showed a tendency towards a lower incidence of postoperative vomiting after the application of 2 mg nabilone compared with 10 mg metoclopramide.…”

New pharmacologic findings for the treatment of PONV and PDNV

“…Although their precise mechanism of preventing PONV is unknown, their effects are thought to be mediated by the drug class's antiinflammatory or membranestabilizing activities peripherally or centrally. 10 Cannabinoids have been demonstrated to be effective and hold promise for a role in treating CINV; however, the literature does not support their use for PONV, 26 …”

Cannabinoide in der Behandlung von �belkeit und Erbrechen

“…In einer randomisierten, doppelblinden Studie wurden 2 mg Nabilone mit 10 mg Metoclopramid zur Verhinderung von postoperativer Übelkeit und Erbrechen bei 53 Frauen nach abdomineller Hysterektomie verglichen [21]. Die Medikamente wurden 90 min vor der Einleitung der Anästhesie verabreicht.…”