Effect of N6-methyladenosine on fat-cell glucose metabolism

Souness, John E.; Stouffer, John E.; Sánchez, Victoria Chagoya de

doi:10.1016/0006-2952(82)90642-6

Cited by 15 publications

(11 citation statements)

References 32 publications

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“…The m 6 A modification has also been reported to be a critical regulator of adipogenesis. In rat adipocytes, the m 6 A modification strongly stimulates glucose oxidation [72]. FTO-mediated m 6 A demethylation is closely related to upregulated adipogenesis, fat mass, and body weight.…”

Section: Rna M 6 a Modification In Developmental Processesmentioning

confidence: 96%

Regulation of RNA N⁶-methyladenosine modification and its emerging roles in skeletal muscle development

Pei

Zhou

et al. 2021

Int. J. Biol. Sci.

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Section: Rna M 6 a Modification In Developmental Processesmentioning

confidence: 96%

Regulation of RNA N⁶-methyladenosine modification and its emerging roles in skeletal muscle development

Pei

Zhou

et al. 2021

Int. J. Biol. Sci.

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“…More than 90% of diabetes is T2D, which is characterized by hyperglycemia and dyslipidemia. Recent released studies have suggested that the m 6 A modification may play a critical role in the regulation of T2D [32,67,68]. For example, m 6 A highly stimulates glucose oxidation in Table 1 The functions of RNA m 6 A methylation in metabolic diseases m 6 A methylation plays crucial roles on the regulation of metabolic diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, hypertension, osteoporosis and immune-related metabolic diseases…”

Section: A Methylation and T2dmentioning

confidence: 99%

RNA N6-methyladenosine: a promising molecular target in metabolic diseases

Wang

Huang

et al. 2020

Cell Biosci

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N6-methyladenosine is a prevalent and abundant transcriptome modification, and its methylation regulates the various aspects of RNAs, including transcription, translation, processing and metabolism. The methylation of N6-methyladenosine is highly associated with numerous cellular processes, which plays important roles in the development of physiological process and diseases. The high prevalence of metabolic diseases poses a serious threat to human health, but its pathological mechanisms remain poorly understood. Recent studies have reported that the progression of metabolic diseases is closely related to the expression of RNA N6-methyladenosine modification. In this review, we aim to summarize the biological and clinical significance of RNA N6-methyladenosine modification in metabolic diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, hypertension, cardiovascular diseases, osteoporosis and immune-related metabolic diseases.

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“…1973;Ebert& Schwabc 1973;Fredholm 1978) and it increases glucose uptake (Schwabe et a/. 1974;Taylor & Halperin 1979: Joost & Steinfelder 1982Souness et a/. 1982) and glucose oxidation (Souness et a/.…”

Section: Discussionmentioning

confidence: 99%

“…1974;Taylor & Halperin 1979: Joost & Steinfelder 1982Souness et a/. 1982) and glucose oxidation (Souness et a/. 1982).…”

Section: Discussionunclassified

The Effect of Alkylxanthines and Other Phosphodiesterase Inhibitors on Adenosine‐Receptor Mediated Decrease in Lipolysis and Cyclic AMP Accumulation in Rat Fat Cells

Fredholm

Lindgren

1984

Acta Pharmacologica et Toxicologica

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Absrract: Cyclic AMP accumulation and glycerol release were studied in isolated rat fat cells. Both processes were inhibited by R-site specific adenosine analogues (L-PIA>NECA>2-chloro-adenosine>D-PIA), but poorly or not at all by the P-site selective analogue SQ 22,536. The effect of a series of xanthine derivatives and of some structurally unrelated phosphodiesterase inhibitors as inhibitors of 2-chloro-adenosine induced inhibition of NA stimulated cyclic AMP accumulation and lipolysis was subsequently examined. The 2-chloroadenosine effect on cyclic AMP accumulation was antagonized by the xanthines with the following order of potency: DPX> 8-phenyl-theophylline> 8-p-sulpho-phenyl-theophylline> verrophylline> IBMX > theo-phylline> H WA 285 > pentoxiphylline >caffeine > 7-benzyl IBMX > theobromine >enprofylline > ZK 62,7 1 1.The rank order potency of xanthines against the antilipolytic effect of 2-chloro-adenosine was the same with two notable exceptions: the two potent phosphodiesterase inhibitors 7-benzyl-IBMX and ZK 62,711 were more than 20 times more potent as inhibitors of the antilipolytic effect of 2-chloro-adenosine. The results show that antagonism of adenosine analogue-induced antilipolytic effects is a convenient assay for adenosine antagonistic potency of drugs, except for drugs with a high potency as phosphodiesterase inhibitors. The lipolytic potency of the xanthine derivatives was also studied. The ability of the xanthines to stimulate basal and noradrenaline stimulated lipolysis was generally in agreement with their potency as adenosine antagonists. Adenosine deaminase induced lipolysis was stimulated by potent phosphodiesterase inhibitors.

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Effect of N6-methyladenosine on fat-cell glucose metabolism

Cited by 15 publications

References 32 publications

Regulation of RNA N⁶-methyladenosine modification and its emerging roles in skeletal muscle development

Regulation of RNA N⁶-methyladenosine modification and its emerging roles in skeletal muscle development

RNA N6-methyladenosine: a promising molecular target in metabolic diseases

The Effect of Alkylxanthines and Other Phosphodiesterase Inhibitors on Adenosine‐Receptor Mediated Decrease in Lipolysis and Cyclic AMP Accumulation in Rat Fat Cells

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Effect of N6-methyladenosine on fat-cell glucose metabolism

Cited by 15 publications

References 32 publications

Regulation of RNA N6-methyladenosine modification and its emerging roles in skeletal muscle development

Regulation of RNA N6-methyladenosine modification and its emerging roles in skeletal muscle development

RNA N6-methyladenosine: a promising molecular target in metabolic diseases

The Effect of Alkylxanthines and Other Phosphodiesterase Inhibitors on Adenosine‐Receptor Mediated Decrease in Lipolysis and Cyclic AMP Accumulation in Rat Fat Cells

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Product

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Regulation of RNA N⁶-methyladenosine modification and its emerging roles in skeletal muscle development

Regulation of RNA N⁶-methyladenosine modification and its emerging roles in skeletal muscle development