Effect of N-[Imino(4-morpholyl)methyl]guanidine on the Oxidative Status in Rats with Toxic Hepatitis

Abstract

The hepatoprotective and antioxidant properties of a synthetic biguanide N-[imino(4-morpholyl)methyl]guanidine (IMMG) were prognosticated by the method of computer prediction. Administration of IMMG was accompanied by a decrease in serum transaminase activity in rats with toxic hepatitis, which reflects inhibition of hepatocyte cytolysis. IMMG treatment was followed by a decrease in biochemiluminescence parameters reflecting the intensity of free radical oxidation. We revealed an increase in activity of aconitase, which was reduced during toxic hepatitis. The content of citrate in the liver and serum was returned to normal under these conditions. IMMG also increased activities of superoxide dismutase and catalase and total antioxidant activity in rat liver. Our results suggest that the hepatoprotective effect of IMMG is associated with its antioxidant activity.

The role of Nox-mediated oxidation in the regulation of cytoskeletal dynamics

“…This inactive form of RhoA is also unable to interact with the GEF Vav2 in in vitro studies [66, 67]. The inactivation of RhoA by this mechanism has also been observed after exposure to highly reactive compounds that cross-link vicinal thiol groups such as phenylarsine oxide (PAO) and platinated-chemotherapeutic agents such as cisplatin (Cis-Diamminedichloroplatinum (II)) or oxaliplatin ((trans-R,R)1,2-Diamino-cyclo-hexaneoxalato-platinum (II)) [68, 69]. …”