Effect of N-butyl cyanoacrylate on fracture healing in segmental rat tibia fracture model

Abstract

BackgroundComminuted fractures can occur due to severe traumas. The treatment of these fractures that may cause serious morbidity and sometimes mortality is N-butyl cyanoacrylate. It has been reported that this adhesive provides sufficient rigid fixation for bone healing. This study aims to examine cyanoacrylate radiologically and histologically to determine whether it provides adequate recovery in segmental fractures. The secondary objective is to evaluate N-butyl cyanoacrylate, an adhesive material that can hold the fragments on the fracture line together following reduction.MethodsSixteen Sprague–Dawley rats were divided in two groups as control (n = 8) and experimental (n = 8) groups. In the control group, segmental fractures were made and fixated with K-wire. In the experimental group, the same surgical procedure was applied and also fragments were stabilized with N-butyl cyanoacrylate.ResultsOn the sixth week, we did not see any statistically significant difference in the radiological scoring between groups. However, the pathological scores of the control group were statistically higher than the cyanoacrylate group.ConclusionsWe found that cyanoacrylate was rapidly and easily applied in the segmental fractures but did not cause any superior radiological and clinical results compared to the control group. The cyanoacrylate had low viscosity, and it was not capable enough to fill the defects formed between osteotomy surfaces. However, it did not adversely affect fracture healing as seen in biopsies taken as a result of follow-ups.

Efficacy and safety of using n-butyl cyanoacrylate in fixation of cranial following trauma and other pathologies.

“…found that the use of the glue was helpful in treatment of to treat comminuted fractures of the anterior wall of the maxillary sinus which could not easily be treated with internal rigid fixation. Also Akcal et al (1) found that cyanoacrylate was rapidly and easily applied in the segmental fractures and it did not adversely affect fracture healing as seen in biopsies during follow-ups.…”

Use of surgical glue for Mason type III radial head fractures

“…The studies of Shermak et al [25] and Amarante et al [26] showed that cyanoacrylate created a foreign body reaction in tissues and was resorbed, but had no toxic effect. An experimental study by Akcal et al [27] showed that cyanoacrylate did not adversely affect fracture healing. For the clinical utilization of cyanoacrylate, several studies received favorable results.…”

Promotion of fracture healing by conjugated linoleic acid in rats

“…The fracture model of rats has been used routinely in the laboratory. 25 As reported here, the model served the purpose of showing CLA role in promoting fracture healing. 2.…”