Effect of Myristica fragrans extract on total body composition in cafeteria diet induced obese rats

Abstract

It is of interest to evaluate the effect of Myristica fragrans on body composition of cafeteria diet induced obese rats. Thirty rats (150-160g) grouped into 5 and each group contains 6 rats. Group-1 was normal control and 2-5 groups were fed with cafeteria diet for 15 weeks to induce obesity. From 16 th week to 25 th week test drugs were given as mentioned in the experimental protocol. Body weight, BMI, changes in body composition was measured by TOBEC, adipose tissue weights, organ weights, abdominal circumference were measured according to standard methods. After 70days of treatment with MFE 200mg/kg, 400mg/kg Body weight reduced by 9.29%, 12.87% respectively. BMI was also decreased. Abdominal circumference, total fat percentage, organ weights, was substantially reduced. At 400mg/kg of MFE has shown maximum potentiality when compared with 200mg/kg. Orlistat 50mg was used as standard drug. Tetrahydrofuran, flavonoids, saponins, present in Myristica fragrans has shown anti obesity activity. Our findings explain the potentiality of phytochemicals as a potent anti obesity agent, provide scientific evidence for its traditional use and suggest the possible mechanism of action.

Effect of Dietary Supplementation of Plant Seeds as Fatty Acids Source on Nutrients Digestibility, Performance, Carcass and Cutting Percentage and Physical Properties Evaluation of Meat of Broiler

“…The seeds are widely used as herbs and spices in many traditional and conventional food industries around the world [25]. The seeds contain phenolic, flavonoid, and other important bioactive compounds [26,27]. Potential phytochemicals in the plant nutmeg have been reported to have antioxidant, antimicrobial, ant pain, ant obesity, and hepatoprotective activities in biological systems [25,27].…”

“…Nutritionally, nutmeg is rich in energy, carbohydrates, protein, dietary fiber, Vitamins A, C, and E, and minerals [32]. Administration of Myristica fragrans extract in the diet has been reported to inhibit lipid digestion, absorption and accumulation of adipose tissue in rats [27]. Supplementation of 200 mg/kg BW ethanol extract of nutmeg did not cause hematological parameters in rats [33].…”

The effects of Myristica fragrans seed meal and Syzygium aromaticum leaf meal dietary supplementation on growth performance and oxidative status of broiler chicken

“…Myristica fragrans, also known as nutmeg, is an aromatic perennial tropical plant with a characteristic scent that possesses multiple medicinal and antioxidant properties (Periasamy et al 2016). Its seed is widely used as herb and spice in many traditional and conventional food industries around the world (Olaleye et al 2006) The seed contains phenolic, flavonoid, and other important bioactive compounds (Zakaria et al 2015;Yakaiah et al 2019). Nutritionally, nutmeg is rich in energy, carbohydrates, proteins, dietary fibre, vitamins (Vitamins A, C, and E) and minerals (Agbogidi and Azagbaekwe 2013).…”

“…Nutritionally, nutmeg is rich in energy, carbohydrates, proteins, dietary fibre, vitamins (Vitamins A, C, and E) and minerals (Agbogidi and Azagbaekwe 2013). The potential phytochemicals in Myristica fragrans plant have been reported to exert antioxidant, antimicrobial, antipain, antiobesity, and hepatoprotective activities in biological systems (Morita et al 2003;Olaleye et al 2006;Agbogidi and Azagbaekwe 2013;Yakaiah et al 2019). The dietary administration of Myristica fragrans extracts was reported to inhibit lipid digestion, absorption and accumulation of adipose tissue in the rat (Yakaiah et al 2019), reduce cholesterol level in rabbits (Sharma et al 1995), and prevent liver damage in the rat (Morita et al 2003).…”

“…The potential phytochemicals in Myristica fragrans plant have been reported to exert antioxidant, antimicrobial, antipain, antiobesity, and hepatoprotective activities in biological systems (Morita et al 2003;Olaleye et al 2006;Agbogidi and Azagbaekwe 2013;Yakaiah et al 2019). The dietary administration of Myristica fragrans extracts was reported to inhibit lipid digestion, absorption and accumulation of adipose tissue in the rat (Yakaiah et al 2019), reduce cholesterol level in rabbits (Sharma et al 1995), and prevent liver damage in the rat (Morita et al 2003). Inclusion of Myristica fragrans seed extracts at 1.25, 2.50, and 5.00% (g/ml) has been demonstrated to improve physicochemical properties and oxidative stability of raw beef during 3-week cold storage at − 18°C compared with control (Zakaria et al 2015).…”