Effect of myricetin on deoxycorticosterone acetate (DOCA)-salt-hypertensive rats

Borde, Pravin; Mohan, Mahalaxmi; Kasture, Sanjay

doi:10.1080/14786410903335190

Cited by 35 publications

(23 citation statements)

References 21 publications

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“…These inflammatory cytokines could cause disturbed energy metabolism (Schilling et al, ), impaired β‐adrenergic signaling(de Montmollin, Aboab, Mansart, & Annane, ), imbalanced calcium homeostasis (Zhong, Hwang, Adams, & Rubin, ), and excess production of nitric oxide (Stein, Frank, Schmitz, Scholz, & Thoenes, ), all of which resulted in impaired contractility, diastolic dysfunction, reduced cardiac index, and ejection fraction (de Montmollin et al, ; Schilling et al, ; Stein et al, ; Zhong et al, ). In previous studies, myricetin has been showed to protect the mouse or rat heart from isoproterenol induced myocardial infarction(Tiwari, Mohan, Kasture, Maxia, & Ballero, ), ischemia/reperfusion induced injury (Scarabelli et al, ), and hypertension (Borde, Mohan, & Kasture, ), and the underlying mechanism was related to the regulation of Stat1 and oxidative stress (Borde et al, ; Scarabelli et al, ; Tiwari et al, ). In in vitro experiments, myricetin could blunt the activation of NF‐κB and inhibit the production of proinflammatory cytokines in H9C2 cardiomyocytes (Chen & Fan, ) and macrophages (Cho et al, ).…”

Section: Discussionmentioning

confidence: 99%

Myricetin attenuated LPS induced cardiac injury in vivo and in vitro

Zhang

Hong

Liao

et al. 2017

Phytotherapy Research

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Sepsis induced myocardial dysfunction (SIMD) is a common complication and leads to an increased mortality. SIMD is closely related to inflammation and oxidative stress. Myricetin exhibits strong capacities of anti-inflammation and anti-oxidative stress, but its pharmacological effects for lipopolysaccharide (LPS) induced cardiac injury remains undefined. This study aimed to explore whether myricetin was efficient to alleviate SIMD in mice and neonatal rat cardiomyocytes injury. Mice administrated with myricetin (100 mg/kg, po, bid) or vehicle groups were challenged with LPS (10 mg/kg, ip), and cardiac functions examined by echocardiography after 12 hr LPS exposure. LPS markedly impaired mouse cardiac functions, which were significantly attenuated by myricetin administration. Myricetin significantly reduced the production of inflammatory cytokines both in serum and cardiac tissue. Myricetin could inhibit the nuclear translocation of p65, degradation of IκBα, and cellular apoptosis in vivo and in vitro. Myricetin also prevented overexpression of iNOS and reduction of oxidoreductase (SOD and GPx) activity. Besides, Myricetin treatment could attenuate production of inflammatory cytokines of peritoneal macrophages stimulated with LPS in vitro. Thus we concluded that myricetin could attenuate the LPS induced cardiac inflammation injury in vivo and in vitro. Myricetin may be a potential therapy or adjuvant therapy for SIMD.

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Section: Discussionmentioning

confidence: 99%

Myricetin attenuated LPS induced cardiac injury in vivo and in vitro

Zhang

Hong

Liao

et al. 2017

Phytotherapy Research

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“…The antihypertensive activity of myricetin has been demonstrated in vivo . Hypertension and oxidative stress initiated by deoxycorticosterone acetate (DOCA) was reduced after treatment with oral doses of 100 and 300 mg myricetin/kg body weight in rats [ 117 ]. A reduction in systolic blood pressure, changes in vascular reactivity and a reversal of DOCA-induced increase in heart rate was evident.…”

Section: Pharmacological Applicationsmentioning

confidence: 99%

Myricetin: A Dietary Molecule with Diverse Biological Activities

et al. 2016

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Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticals value. It is one of the key ingredients of various foods and beverages. The compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities. It displays several activities that are related to the central nervous system and numerous studies have suggested that the compound may be beneficial to protect against diseases such as Parkinson’s and Alzheimer’s. The use of myricetin as a preserving agent to extend the shelf life of foods containing oils and fats is attributed to the compound’s ability to protect lipids against oxidation. A detailed search of existing literature revealed that there is currently no comprehensive review available on this important molecule. Hence, the present work includes the history, synthesis, pharmaceutical applications and toxicity studies of myricetin. This report also highlights structure-activity relationships and mechanisms of action for various biological activities.

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“…Elevated reactive oxygen species-induced oxidative stress had been reported in human and different animal models of hypertension [23][24][25]. Oxidative stress causes the reduction of NO bioavailability due to removing NO by a super oxide radical and decreasing NO synthesis/release from endothelium.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension

et al. 2014

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Hypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on hypertension. Hypertension was induced by using the deoxycorticosterone acetate (DOCA)-induced (15 mg/kg twice per week, subcutaneously) salt-sensitive hypertension model of Wistar rats. Hypertension caused a decrease in endotheliumdependent relaxations of the isolated thoracic aorta. Resveratrol treatment (50 mg/l in drinking water) prevented DOCA salt-induced hypertension, but did not improve endothelial dysfunction. Plasma nitric oxide (NO), asymmetric dimethylarginine (ADMA), total antioxidant capacity (TAC) and hydrogen sulfide (H 2 S) levels were not changed by DOCA salt application. However, treatment of resveratrol significantly decreased ADMA and increased TAC and H 2 S levels. NO level in circulation was not significantly changed by resveratrol. DOCA salt application and resveratrol treatment also caused an alteration in the epigenetic modification of vessels. Staining pattern of histone 3 lysine 27 methylation (H3K27me3) in the aorta and renal artery sections was changed. These results show that preventive effect of resveratrol on DOCA salt-induced hypertension might due to its action on the production of some blood biomarkers and the epigenetic modification of vessels that would focus upon new aspect of hypertension prevention and treatment.

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Effect of myricetin on deoxycorticosterone acetate (DOCA)-salt-hypertensive rats

Cited by 35 publications

References 21 publications

Myricetin attenuated LPS induced cardiac injury in vivo and in vitro

Myricetin attenuated LPS induced cardiac injury in vivo and in vitro

Myricetin: A Dietary Molecule with Diverse Biological Activities

Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension

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