Effect of muscle weakness distribution on balance in neuromuscular disease

Kaya, Pınar; Alemdaroğlu, I.; Yılmaz, Öznur; Karaduman, Ayşe; Topaloğlu, Haluk

doi:10.1111/ped.12428

Cited by 20 publications

(18 citation statements)

References 22 publications

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“…The association between muscle weakness and standing impairments is reported by several authors19202627, and, in the current study, it is supported by the following two outcomes.…”

Section: Discussionsupporting

confidence: 86%

Quantitative analysis of upright standing in adults with late-onset Pompe disease

Valle

Casabona

Fiumara

et al. 2016

Sci Rep

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Pompe disease is a rare disorder producing muscle weakness and progressive impairments in performing daily motor activities, such as walking and standing. Most studies have focused on dysfunctions at cellular level, restricting the examination of gross motor functions to qualitative or subjective rating scales evaluations. With the aim of providing an instrumented quantification of upright standing in Pompe disease, we used a force platform to measure the center of pressure over three foot positions and with eyes open and closed. Amplitude and variability of body sway were measured to determine the level of postural stability, while power spectrum analysis and nonlinear computations were performed to explore the structure of the postural control. In comparison with healthy participants, patients with Pompe disease showed a reduced level of postural stability, but irrelevant variations in frequency content and spatio-temporal structure of the sway motion were detected. Changes in foot position did not increase the postural instability associated with Pompe disease, but prominent worsening occurred in the patients when they stand with eyes closed, particularly along the anterior-posterior direction. These results provide objective elements to monitor deficiencies of upright standing in Pompe disease, emphasizing the specific contributions of sway direction and sensory deficits.

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“…The association between muscle weakness and standing impairments is reported by several authors19202627, and, in the current study, it is supported by the following two outcomes.…”

Section: Discussionsupporting

confidence: 86%

Quantitative analysis of upright standing in adults with late-onset Pompe disease

Valle

Casabona

Fiumara

et al. 2016

Sci Rep

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“…The present study aimed to identify and interpret stabilometric variables that assess the static postural control of children and adolescents with CMT and shows ways of using CoP to maintain postural stability, in the presence of distal weakness and somatosensory impairments. Studies in the literature have shown that stabilometric assessment is capable of distinguishing poor and appropriate balance in children[ 9 , 49 – 52 ] and adults[ 23 – 25 , 53 , 54 ]. To the extent of our knowledge, this is the first original study focused on classical stabilometric parameters, in children and adolescents with CMT.…”

Section: Discussionmentioning

confidence: 99%

“…To the extent of our knowledge, this is the first original study focused on classical stabilometric parameters, in children and adolescents with CMT. Kaya et al [ 52 ]explored only the percentage of oscillation of CoP in children with Duchenne muscular dystrophy and different polyneuropathic diseases, while others have studied balance impairment in adults with neuropathies[ 23 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pathological conditions in children, especially neuromuscular diseases, such as neuropathies show increased anteroposterior CoP oscillation, while Duchenne muscular dystrophy shows increased mediolateral oscillation[ 21 ]. Hereditary sensory-motor neuropathies (HSMN), as Charcot-Marie-Tooth (CMT), affect 9.4 to 20 in 100 000 people [ 22 ] independently of gender.…”

Section: Introductionmentioning

confidence: 99%

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Characterizing postural oscillation in children and adolescents with hereditary sensorimotor neuropathy

et al. 2018

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Charcot Marie Tooth disease (CMT) has negative functional impact on postural control of children; however, it has not been widely studied. Stabilometry can provide insights about postural control and guide preventive interventions in immature perceptual and musculoskeletal systems as those seen in children with CMT. This cross-sectional study aimed to identify and interpret stabilometric variables that reflect the postural control of children with CMT. 53 subjects (age 6–17) were assigned to one of the two groups: CMT (15 males and 14 females with CMT) or Control (13 males and 11 females healthy). Quiet standing was tested in different conditions: with open and closed eyes on regular surface (open-regular, closed-regular) and foam surface (open-foam, closed-foam) using a force platform. The minimum of 2 and maximum of 3 trials of 30 seconds for each test condition provided the classical stabilometric variables and Romberg Quotient (RQv). CMT group showed increase of confidence ellipse area, mean velocity, mediolateral and anteroposterior velocities associated with decreased mean body oscillation frequency, as the complexity of tasks increased. CMT postural deficit was identified by greater and faster sway associated with these lower frequencies, when compared to Control.

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“…Weakness in the upper and lower limbs is a common symptom of multiple diseases, including neuromuscular disorders ( 14 ), amyotrophic lateral sclerosis ( 15 ), multiple sclerosis, Guillain-Barre syndrome, transverse myelitis ( 16 ), hypovitaminosis D ( 17 ) and POEMS syndrome. Hence, presentation with weakness in the upper and lower limbs in patients with POEMS syndrome may not result in the correct diagnosis.…”

Section: Introductionmentioning

confidence: 99%

POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report

et al. 2017

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Polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes (POEMS) syndrome is a rare variant of plasma cell disorders with multiple systemic manifestations. A 50-year-old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclonal plasma cell disorder (typicallyλ-restricted in cases of POEMS syndrome); sclerotic lesions on the spine and pelvis; organomegaly, including hepatomegaly, splenomegaly and lymphadenopathy; edema; pleural effusion; adrenal, thyroidal, pituitary, gonadal and pancreatic endocrinopathy; skin changes, including hyperpigmentation, dry skin and hypertrichosis; thrombocytosis; pulmonary hypertension; low vitamin B12 and weight loss. Following the diagnosis of POEMS syndrome, the patient was treated only with pain-alleviating corticosteroids. Respiratory failure-induced mortality occurred 24 months after the patient first experienced difficulty walking and numbness in her lower extremities. The present study suggests that abnormal symptoms in cases of POEMS syndrome should be further evaluated during the diagnosis and treatment.

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Effect of muscle weakness distribution on balance in neuromuscular disease

Cited by 20 publications

References 22 publications

Quantitative analysis of upright standing in adults with late-onset Pompe disease

Quantitative analysis of upright standing in adults with late-onset Pompe disease

Characterizing postural oscillation in children and adolescents with hereditary sensorimotor neuropathy

POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report

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