Effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors in rat brain

Grigoriev, V. V.; Petrova, L. N.; Gabreliyan, A. V.; Ivanova, T. A.

doi:10.1007/s10517-008-0283-3

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Однако начиная с концентрации 1´10 -13 M и до 1´10 -9 M MDP вызывали увеличение KK-активируемых токов, но в концентрации 1´10 -8 M MDP вновь вызывали небольшую блокаду KK-вызванных токов (рис. 6) [7]. оБсУждение Таким образом, установлено, что исследованные эндогенные пептиды играют важную роль в регуляции глутаматергической медиаторной системы мозга.…”

Section: результатыunclassified

Effect of endogenous peptides on the currents Of NMDA- AND AMPA-receptors of neurons of the cortex, hippocampus and cerebellum of rat brain

Grigoriev

Bovina

2018

BMCRM

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The obtained results show that endogenous peptides play an important role in the regulation of the glutamatergic mediator system of the brain. They act in extremely low concentrations, starting at 1 × 10–14 M, their effects are concentration-dependent and reversible, thus indicating the exclusive specificity of the corresponding receptors. The range of their influence on responses of postsynaptic glutamate receptors is rather narrow and, as a rule, does not exceed 60-70% of control. We have demonstrated for the first time that CLIP blocks NMDA receptors and potentiates AMPA receptors in a wide range of concentrations (6 orders of magnitude); this is very important for manifestation of memory-stimulating effect. Somatostatin blocking NMDA receptors and potentiating AMPA receptors, also plays an important role in the mechanisms of memory formation. Obviously, there is a great similarity in the action of both peptides on AMPA and NMDA receptors. Thus our results provide the first information about regulation of including cognitive processes and memory mechanisms by endogenous compounds. This mechanism particularly involves regulation of AMPA and NMDA receptors in the brain.

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Section: результатыunclassified

Effect of endogenous peptides on the currents Of NMDA- AND AMPA-receptors of neurons of the cortex, hippocampus and cerebellum of rat brain

Grigoriev

Bovina

2018

BMCRM

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“…It is an inflammation-inducing molecule in the central nervous system (CNS) disorders (Cheng et al, 2018;Liu et al, 2015). Moreover, it exacerbates neuronal damage and down-regulates cognition-related receptors (Grigoriev et al, 2008). Hence, MDP might play a pathological role in AD.…”

Section: Introductionmentioning

confidence: 99%

Muramyl dipeptide promotes Aβ1-42 oligomer production via the NOD2/p-p38 MAPK/BACE1 signaling pathway in the SH-SY5Y cells

Chen¹,

Chan²,

Chen³

et al. 2020

Journal of Integrative Neuroscience

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The relationship between chronic bacterial colonization in the brain and Alzheimer's disease is attracting extensive attention. Recent studies indicated that the components of bacterial biofilm drive the amyloid-β production. Muramyl dipeptide, the minimal bioactive peptidoglycan motif common to all bacteria, contributes to the development of many central inflammatory and neurodegenerative disorders. However, the involvement of Muramyl dipeptide in amyloid-β production is not completely defined. In our present study, wild type mice received an intracerebroventricular injection of normal saline or Muramyl dipeptide. Data showed that the production of Aβ1-42 oligomers was significantly increased after Muramyl dipeptide injection in the wild type mice or incubation of the SH-SY5Y cells with Muramyl dipeptide. Moreover, the action of Muramyl dipeptide was dose-and timedependent. The above results suggested a possibility that the Muramyl dipeptide -induced Aβ1-42 oligomer production might be related to the NOD2/p-p38 MAPK/BACE1 pathway. To confirm this, the SH-SY5Y cells were transfected with siRNA NOD2. Data showed that the transfected SH-SY5Y cells exhibited decreased expression of Aβ1-42 oligomer, NOD2, p-p38 MAPK, and BACE1 after treatment with Muramyl dipeptide. Finally, SH-SY5Y cells were pretreated with SB203580, an inhibitor of the p-38-MAPK pathway. The results indicated that these pretreated SH-SY5Y cells exhibited decreased expression of Aβ1-42 oligomer, p-p38 MAPK, and BACE1 after treatment with Muramyl dipeptide. In conclusion, these results suggested that Muramyl dipeptide was the trigger factor for Aβ1-42 oligomer production, which probably acts via the NOD2/p-p38 MAPK/BACE1 signaling pathway.

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Effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors in rat brain

Cited by 2 publications

References 11 publications

Effect of endogenous peptides on the currents Of NMDA- AND AMPA-receptors of neurons of the cortex, hippocampus and cerebellum of rat brain

Effect of endogenous peptides on the currents Of NMDA- AND AMPA-receptors of neurons of the cortex, hippocampus and cerebellum of rat brain

Muramyl dipeptide promotes Aβ1-42 oligomer production via the NOD2/p-p38 MAPK/BACE1 signaling pathway in the SH-SY5Y cells

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