Effect of multiple, simultaneous vaccines on polio seroresponse and associated health outcomes

Immune Responses in U.S. Military Personnel Who Received Meningococcal Conjugate Vaccine (MenACWY) Concomitantly with Other Vaccines Were Higher than in Personnel Who Received MenACWY Alone

“…The findings here are in agreement with those found in a study of IPV administered alone or along with multiple other vaccines in military personnel (10), despite the fact that the concomitant vaccines varied from those evaluated in this study. In the IPV study, inclusion of Tdap resulted in a significant increase in the number of seroconversions in the study group receiving multiple vaccinations (Ͼ4 vaccines).…”

“…For example, inactivated polio vaccine (IPV) given alone or coadministered with other vaccines in military personnel showed that seroconversions to polio were more likely when multiple vaccines were administered (10). In contrast, it has been reported that immune response to the concomitant administration of the tetanus-diphtheria-acellular pertussis (Tdap) vaccine and the trivalent influenza vaccine was reported to be noninferior to sequential administration despite lower concentrations of antibody to tetanus, diphtheria, and pertussis toxin components (11,12).…”

Use of Inactivated Polio Vaccine Among U.S. Adults: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2023

“…A national serosurvey conducted during 2009-2010 determined that ≥79% of adults aged 20-49 years have antibodies to poliovirus types 1, 2, and 3 (18), indicating the persistence of antibodies for at least several decades. No data on comparative vaccine effectiveness of a primary series alone versus a primary series plus booster IPV dose exist; however, studies in groups of adults with varying vaccination histories and a range of prebooster seroprevalences have demonstrated that administering an IPV booster dose increases the percentage of adults who are seropositive to 98%-100% (19)(20)(21)(22)(23)(24). Although the need for an IPV booster after primary polio vaccination is uncertain, some adults might benefit from the increased immunity provided by an additional IPV dose when exposure to poliovirus can reasonably be expected.…”