Effect of multiple light paths on retinal vessel oximetry

Smith, Matthew H.; Denninghoff, Kurt R.; Lompado, Arthur; Hillman, Lloyd W.

doi:10.1364/ao.39.001183

Cited by 52 publications

(39 citation statements)

References 26 publications

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“…54 NBI is a new optical technology that can clearly visualize the microvascular structure on mucosal surfaces, 55,56 using a new narrow banding filter on an red/green/blue sequential videoscope system, instead of the conventional red/green/blue broadband filter. The filter cuts all wavelengths in illumination except for narrow bands in the blue and green spectrum, centered at 415 nm and 540 nm, coinciding with the peak absorption spectrum of oxyhemoglobin (the main chromophore in bronchial tissues), 57 making blood vessels more pronounced when viewed in NBI mode. 58 The 415 nm blue light is absorbed by capillary vessels in the surface layer of the mucosa, whereas the 540 nm wavelength is strongly absorbed by blood vessels located below the capillary vessels in the surface layer of the mucosa.…”

Section: Diagnostic Performance Of Afi Versus Narrow-band Imagingmentioning

confidence: 99%

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Wang

et al. 2013

Respir Care

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SummaryBronchoscopy technology is a desirable method for detecting lung cancers arising in the central airways. Most early cancers and precancerous lesions are not visible on conventional white-light bronchoscopy (WLB). Autofluorescence bronchoscopy (AFB) is a newly developed technology that exploits the difference in autofluorescence intensity between normal and tumorous tissues to detect bronchial cancers and precancerous lesions. Several types of AFB systems have been used in clinical practice, and autofluorescence imaging videobronchoscopy (AFI) is one of these AFBs. In most of the studies on AFB other than AFI, AFB has provided a much higher sensitivity but a lower specificity than WLB. Regarding AFI, recent studies have reported controversial results on the sensitivity and specificity for detecting cancers and precancerous lesions, compared with WLB. In this paper we describe the working mechanisms and characteristics of AFBs, mainly AFI, and the diagnostic performance of AFI, compared with WLB, other AFBs, and narrow-band imaging, for detecting lung cancers and precancerous lesions. Key words: autofluorescence imaging videobronchoscopy; autofluorescence bronchoscopy; white-light bronchoscopy; narrow-band imaging; lung cancer; precancerous lesion. [Respir Care 2013;58(12):2150 -2159

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Section: Diagnostic Performance Of Afi Versus Narrow-band Imagingmentioning

confidence: 99%

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Wang

et al. 2013

Respir Care

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“…When a small spot of laser light is directed onto a blood vessel in the eye, there are many possible paths it can traverse. [26][27][28][29][30] Two paths of particular interest for this discussion are: (i) light specularly reflected from the blood vessel (also known as a glint) and (ii) laterally scattered light that has interacted with the red blood cell-packaged hemoglobin in the vessel and scattered back out of the eye. Figure 1(a) shows an example of the specular vessel glint path and Fig.…”

Section: Specular Vessel Glintmentioning

confidence: 99%

Retinal oximeter for the blue-green oximetry technique

et al. 2011

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Abstract. Retinal oximetry offers potential for noninvasive assessment of central venous oxyhemoglobin saturation (SO 2 ) via the retinal vessels but requires a calibrated accuracy of ± 3% saturation in order to be clinically useful. Prior oximeter designs have been hampered by poor saturation calibration accuracy. We demonstrate that the bluegreen oximetry (BGO) technique can provide accuracy within ± 3% in swine when multiply scattered light from blood within a retinal vessel is isolated. A noninvasive on-axis scanning retinal oximeter (ROx-3) is constructed that generates a multiwavelength image in the range required for BGO. A field stop in the detection pathway is used in conjunction with an anticonfocal bisecting wire to remove specular vessel reflections and isolate multiply backscattered light from the blood column within a retinal vessel. This design is tested on an enucleated swine eye vessel and a retinal vein in a human volunteer with retinal SO 2 measurements of ∼1 and ∼65%, respectively. These saturations, calculated using the calibration line from earlier work, are internally consistent with a standard error of the mean of ± 2% SO 2 . The absolute measures are well within the expected saturation range for the site (-1 and 63%). This is the first demonstration of noninvasive on-axis BGO retinal oximetry. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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“…For oximetry analysis of multispectral data, we employ a custom algorithm based on previous work by van der Putten et al, (2016) 19 and by Smith et al, (2000). 20 We derived a custom analytical model for the transmission of light through blood vessels at each waveband, described in equation 1.…”

Section: Oximetry Analysismentioning

confidence: 99%

“…20 We derived a custom analytical model for the transmission of light through blood vessels at each waveband, described in equation 1.…”

Section: Oximetry Analysismentioning

confidence: 99%

Minimally invasive optical biopsy for oximetry

2017

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The study of localised oxygen saturation in blood vessels can shed light on the etiology and progression of many diseases with which hypoxia is associated. For example, hypoxia in the tendon has been linked to early stages of rheumatoid arthritis, an auto-immune inflammatory disease. Vascular oximetry of deep tissue presents significant challenges as vessels are not optically accessible. In this paper, we present a novel multispectral imaging technique for vascular oximetry, and recent developments made towards its adaptation for minimally invasive imaging. We present proof-of-concept of the system and illumination scheme as well as the analysis technique. We present results of a validation study performed in vivo on mice with acutely inflamed tendons. Adaptation of the technique for minimally invasive microendoscopy is also presented, along with preliminary results of minimally invasive ex vivo vascular oximetry.

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Effect of multiple light paths on retinal vessel oximetry

Cited by 52 publications

References 26 publications

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Retinal oximeter for the blue-green oximetry technique

Minimally invasive optical biopsy for oximetry

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