Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis

Venegas-Sanabria, Luis Carlos; Cavero‐Redondo, Iván; Martínez‐Vizcaíno, Vicente; Cano-Gutiérrez, Carlos Alberto; Álvarez‐Bueno, Celia

doi:10.1186/s12877-022-03302-1

Cited by 32 publications

(27 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Especially appealing may be the potential benefits of the Vivifrail MCE program on the cognitive domain of older adults with mild cognitive impairment (MCI). Despite previous research has shown that exercise might be an effective intervention to cognition in healthy older adult populations [ 30 ], so far, its effectiveness in MCI/dementia populations is less clear [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

et al. 2022

View full text Add to dashboard Cite

Introduction The World Health Organisation recently defined the construct of intrinsic capacity (IC), a function-based marker of older adult’s health encompassing all mental and physical capacities of the individual. Multicomponent physical exercise (MCE) is a potential intervention capable to maintain/increase IC at older age; however, evidence is scarce on the effects of MCE on IC in cognitively impaired pre-frail/frail older adults. Methods Secondary analyses of a randomised clinical trial. One hundred and eighty-eight older outpatients (age = 84.06 ± 4.77, 70.2% women) presenting with pre-frailty/frailty (according to Fried Criteria) and mild cognitive impairment (MCI)/mild dementia were recruited in the Geriatric clinics of three tertiary hospitals in Spain. Subjects were randomised to participate in the 12-week home-based individualised Vivifrail MCE or usual care. An IC index was created based on the z-score of the locomotion (Short Physical Performance Battery), cognitive (Montreal Cognitive Assessment), psychology (15-item Geriatric Depression Scale Yesavage) and vitality (handgrip strength) domains. Results After the 3-month intervention, linear mixed models showed significant between-group differences in the evolution of the IC composite score (β=0.48; 95% confidence interval [CI] = 0.24, 0.74; P < 0.001), IC Locomotion (β = 0.42; 95% CI = 0.10, 0.74; P < 0.001), IC Cognition (β = 0.45; 95% CI = 0.03, 0.87; P < 0.05) and IC Vitality domains (β = 0.50; 95% CI = 0.25, 0.74 at 3-month) favouring the MCE group. Conclusions The 12-week Vivifrail multicomponent exercise program is an effective strategy to enhance IC, especially in terms of locomotion, cognition and vitality IC domains in community-dwelling older adults with pre-frailty/frailty and MCI/mild dementia, compared to usual care.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Accordingly, we suggest that the community and families should work together to develop appropriate exercise programs, such as tai chi, baduanjin, qigong, and yoga, to improve sleep quality and cognitive function among older adults with T2DM. A comprehensive exercise program not only offers a variety of pleasurable activities to alleviate depression, it can also improve motor and cognitive performance by providing multiple stimulation of thought, attention, and memory, 60 which can be more beneficial than a single cognitive or exercise program. We also found that high levels of sleep quality were associated with lower depressive symptoms and lower risk of developing COI.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Physical Exercise and Cognitive Impairment Among Older Adults with Type 2 Diabetes: Chain Mediating Roles of Sleep Quality and Depression

Zhang¹,

Zhang²,

Sheng³

et al. 2023

PRBM

View full text Add to dashboard Cite

Objective Although physical exercise has been shown to boost physical, psychological, and psychiatric conditions in older adults, there is a relative lack of research on the mechanisms involved in this process for older adults with type 2 diabetes mellitus (T2DM). We thus evaluated whether sleep quality and depression mediated the relationship between physical exercise and cognitive impairment in older adults with T2DM by focusing on the exercise–physiology–psychology and psychiatry connection. Methods Self-reported data were collected from 2646 older adults with T2DM in Weifang, Shandong, China. Regression and bootstrap analyses were conducted to explore the chain mediator model including physical exercise, cognitive impairment, sleep quality, and depression. Results Engaging in physical exercise (coefficient = −0.6858, p < 0.001), high levels of sleep quality (coefficient = −0.3397, p = 0.015), and low levels of depression (coefficient = 0.3866, p < 0.001) were significantly associated with a low level of cognitive impairment. Sleep quality and depression mediated the chain effect between physical exercise and cognitive impairment (total effect = −1.0732, 95% CI [−1.3652, −0.7862]; direct effect = −0.6858, 95% CI [−0.9702, −0.3974]; indirect effect = −0.3875, 95% CI [−0.5369, −0.2521]). Conclusion Physical exercise may improve sleep quality in older adults with T2DM, alleviating depression and delaying the development of cognitive impairment. Physical exercise can enhance patients’ ability to resist depression and cognitive impairment, and creating comfortable sleep environments can also reinforce the effects of this process. These findings have important implications for promoting healthy aging in older adults with T2DM.

show abstract

“…Furthermore, Chen et al, reported that exercise training can have a positive effect on cognition and executive function in elderly, but the effect may differ depending on the age of the elderly [ 39 ]. In addition, considering that the upregulation of neurotrophic factors through exercise training can benefit the cognitive function of the elderly [ 40 , 41 ], it is suggested that further studies need to verify changes in cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise Training on Neurotrophic Factors and Blood–Brain Barrier Permeability in Young-Old and Old-Old Women

Cho

Roh

2022

IJERPH

View full text Add to dashboard Cite

Aging and regular exercise may have opposite effects on brain health, and although oxidative stress and sirtuins may be involved in these effects, studies on this topic are limited. Accordingly, the present study aimed to verify the effect of exercise training on oxidant–antioxidant balance, neurotrophic factors, blood–brain barrier permeability, and sirtuins in young-old and old-old women. The study participants were 12 women aged 65–74 years (Young-Old group) and 12 women aged 75–84 years (Old-Old group). All of the selected participants performed exercise training consisting of treadmill walking and resistance band exercise three times a week for 12 weeks. Blood samples were collected before and after exercise training to analyze serum oxidant–antioxidant markers (reactive oxygen species [ROS], superoxide dismutase [SOD]), neurotrophic factor (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor [VEGF]) levels, and blood–brain barrier permeability marker (S100 calcium-binding protein β [S100β], matrix metalloproteinase-9 [MMP-9]) levels, and sirtuin (SIRT-1, SIRT-2, SIRT-3) levels. The Young-Old group showed significantly increased SOD, BDNF, VEGF, SIRT-1, and SIRT-3 levels after training in comparison with the levels before training (p < 0.05), and a significantly higher BDNF level than the Old-Old group after training (p < 0.05). On the other hand, the Old-Old group showed significantly higher SIRT-1 levels after training in comparison with the levels before training (p < 0.05). Thus, exercise training may be effective in increasing the levels of neurotropic factors and reducing blood–brain barrier permeability in the elderly women, and increased antioxidant capacity and elevated levels of sirtuins are believed to play a major role in these effects. The positive effect of exercise may be greater in participants of relatively young age.

show abstract

Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis

Cited by 32 publications

References 50 publications

Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

Relationship Between Physical Exercise and Cognitive Impairment Among Older Adults with Type 2 Diabetes: Chain Mediating Roles of Sleep Quality and Depression

Effects of Exercise Training on Neurotrophic Factors and Blood–Brain Barrier Permeability in Young-Old and Old-Old Women

Contact Info

Product

Resources

About